My Weird Prompts

Why the Same Antidepressant Hits Different People Completely Differently

27 min · 5. Juni 2026
Episode Why the Same Antidepressant Hits Different People Completely Differently Cover

Beschreibung

Two people, same drug, opposite outcomes. The answer is in your liver enzymes and brain receptors. This episode unpacks how CYP2D6, CYP2C19, and CYP3A4 variants can turn a standard dose into an overdose or a sugar pill — and why brain receptor polymorphisms like 5-HTTLPR and COMT Val158Met matter just as much.

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