Honestquo Venture Podcast

Early-Stage Biotech Investing: Inside the Mind of Yaniv Sneor

Ever wondered what it takes to invest in the cutting-edge of biotech? In this episode, we sit down with Yaniv Sneor, a serial entrepreneur turned life science angel investor, to explore the world of early-stage biotech investing. From founding and scaling companies to building a niche angel investment group, Yaniv shares insights on: * The differences between public market investing vs. angel investing in biotech * How his group conducts rigorous due diligence on transformative companies * Key qualities and metrics he looks for in founders and startups * Strategies for accredited investors to navigate the life sciences landscape * The potential for high returns and why early-stage investments matter Whether you’re an investor, entrepreneur, or just curious about the intersection of science and finance, this episode gives a rare, insider look at how angels identify and support the next generation of breakthrough therapies and devices.

Andrew Gazdecki: From Bizness Apps to Acquire.com – Inside Startup Exits and Building Founder-Friendly M&A

Andrew Gazdecki, founder and CEO of Acquire.com, joins the show for a candid conversation on his journey from bootstrapping Bizness Apps in college to selling startups and creating the “world’s most founder-friendly startup acquisition marketplace.” In this episode, Andrew shares how growing up outside the Ivy League shaped his founder grit, the lessons learned building multiple companies, and why he believes sales— not pedigree— is the ultimate founder skill. He breaks down the realities of selling a SaaS business, what he wishes more founders knew about exits, and the moments when it’s time to pivot (or walk away). You’ll hear Andrew’s take on doing customer support solo during COVID, paying $240K for Acquire.com’s domain, and creating a platform that gives sellers control instead of feeling like “just another investment bank deal.” Packed with practical advice for non-technical founders, real talk on regret versus timing in sales, and unique insights on the M&A process, this episode is for anyone serious about building and selling founder-led businesses.

Jordan Fliegel : From Pro Basketball to Startup Exits, Ex-Techstars MD, and Now Backing Acquisition Entrepreneurs

Jordan Fliegel: (Co-CEO of Shareholder Ventures, 5x Founder, Ex-Techstars MD) unpacks his journey from professional basketball benchwarmer to serial entrepreneur—and why he’s now helping others **buy profitable businesses** instead of starting them. **🗝️ HIGHLIGHTS YOU CAN’T MISS:** - **The $5M SBA Loan Hack:** How to acquire cash-flowing businesses with 80-90% debt (even without personal capital). - **"Pizza Dinner Growth Hacks":** How being his own first CoachUp coach + bribing coaches with pizza scaled a marketplace. - **Pro Sports → Startups:** NBA-level teamwork drills for hiring talent who outshine you. - **Why He Quit Venture Capital:** "Buying boomer-retiring businesses beats startups for 99% of entrepreneurs." - **Brutal Founder Truths:** "If you need nights/weekends totally free? **Don’t be an entrepreneur.**" **🔍 For:** First-time founders, burnt-out VCs, bankers, operators & anyone eyeing the $10T small-business transfer wave. 👉 Follow Honestquo for unscripted talks with builders.

From Lab to IPO: Dr. Stephen Squinto on Building Iconic Biotech Companies

Dr. Stephen Squinto — co-founder of Alexion, early Regeneron scientist, and now biotech investor at J.P. Morgan — reflects on a 40-year journey in biotech. He shares what it was like to build Alexion from scratch, lessons from clinical failures, how to spot undervalued technologies, and what most founders get wrong. We talk about the evolution of biotech from the 1980s to the AI era, the realities of drug development, and what makes a great founding team. Honest, practical, and rare insight from someone who’s done it all — from the lab bench to global scale.

Dr. Lydia Villa-Komaroff: The Scientist Who Engineered Insulin & Shaped Biotech

Dr. Lydia Villa-Komaroff — the Mexican American molecular biologist whose breakthrough insulin gene cloning changed medicine forever — shares her trailblazing journey. At 78, she reflects on: 🔬 Pioneering the Biotech Revolution: • The cutthroat race to clone insulin in the 1970s (and the blizzard that almost derailed it ❄️). • How her team’s work birthed Genentech & Biogen — and transformed diabetes treatment worldwide. 💼 From Lab to Boardroom: • Why she left Harvard to lead a startup (and mortgaged her house to save it). • Lessons on resilience: "In business, rule #1 is: Don’t run out of money." 🌍 Truths on Diversity & Aging: • Why diversity isn’t "nice to have" — it’s essential for scientific breakthroughs. • Her take on immortality: "Humans shouldn’t live forever. Children bring the new ideas." • The future of biotech: AI’s role, inflammation research, and tackling Parkinson’s. A masterclass in reinvention from a woman who refused to be boxed in — by academia, age, or expectations. #Biotech #WomenInSTEM #Insulin #Aging #DiversityInScience #StartupLife #ScienceHistory