Rings a Bell

Episode 6 - Anxiety with Rami Safi

Are you anxious about what you don’t remember about anxiety therapy? Well have I got a treat for you. Episode 6 of Rings A Bell Podcast! Rami Safi, a pharmacist and psychotherapist (qualifying) brings us the good bad and the ugly of anxiety management. Enjoy a comprehensive overview of pathophysiology, pharmacology and therapeutics with a few helpful tips for managing your own anxiety along the way! Topics Covered 00:00 - Introduction and housekeeping 00:44 - Rami’s journey from pharmacist to pharmacist and psychotherapist 07:22 - Pervasiveness and importance of anxiety 08:45 - Connection between perfectionism and anxiety 11:30 - Neurotransmitters involved in anxiety disorders 13:22 - Neurobiological difference between panic attack and generalized anxiety disorder 19:25 - Role of the amygdala in fear and anxiety 21:50 - First line treatments for generalized anxiety disorder 26:36 - Rapid nervous system regulation techniques 34:07 - St. John’s Wort risks in anxiety disorders 35:38 - Appropriate times to use benzodiazepines in anxiety treatment 36:11 - Managing side effects of selective serotonin reuptake inhibitors 37:45 - Importance of deprescribing benzodiazepines in elderly people 39:29 - Benzodiazepine pharmacokinetics (volume of distribution) (rate of clearance) (implications in obesity and elderly) 42:25 - Preferred benzodiazepines in elderly people 43:02 - Mechanism of action of buspirone 44:25 - Meds used in psychology with narrow therapeutic window 45:52 - Lithium and kidney function 47:49 - Serious drug interactions with SSRIs 48:45 - Intersection of chronic pain, depression and insomnia 50:35 - moral model of substance use vs. biopsychosocial model of substance use 56:34 - wrap up Connect with Rami Safi LinkedIn: https://www.linkedin.com/in/rami-s-98186718/ [https://www.linkedin.com/in/rami-s-98186718/] Wellness Wave Pharmacy in Hamilton: https://wellnesswavepharmacy.ca/ [https://wellnesswavepharmacy.ca/]  All the Links! Find all the links to all the things (references, resources, buy me a coffee, email list, etc) here: https://ringsabellpod.kit.com/allthethings [https://ringsabellpod.kit.com/allthethings]  #anxiety #pathophysiology #pharmacology #anxietytherapeutics #therapeutics #continuingeducation#continuingeducation #pharmacy #pharmacylife #pharmacylyfe #pharmacistlife #pharmacistlyfe #itsmyanxiety #weallhaveanxiety #anxietymanagement #ssris #snris #serotonin #dopamine #norepinephrine #panicattacks #bzds #benzos #obesitymedicine #geriatricmedicine #benzodiazepines #diazepam #pharmacokinetics #volumeofdistribution #eliminationhalflife #neurology #psychotherapy #cbt #cognitivebehaviouraltherapy #GAD #generalizedanxietydisorder #SJW #stjohnswort #substanceuse ---------------------------------------- Hosted on Acast. See acast.com/privacy [https://acast.com/privacy] for more information.

Episode 5 - Antibiotic Stewardship with Brad Phillips

EPISODE 5 - ANTIBIOTIC STEWARDSHIP WITH BRAD PHILLIPS EPISODE 5 PROVIDES: * A refresher on bacteriostatic vs. bactericidal antibiotics * The ACTUAL rates of true penicillin allergy * Why “walking pneumonia” is more of a slang term than a diagnosis  * The declining efficacy of azithromycin  * Where to find up to date resistance patterns * Some oral options for uncomplicated MRSA * Adapting prescriptions with confidence * and much more! THINKWEAR COLLECTIVE! You can purchase Thinkwear at https://lindsay-dixon-shop.fourthwall.com/en-cad [https://lindsay-dixon-shop.fourthwall.com/en-cad]  Enter the giveaway by interacting with the show in the following ways: * comment or share any of the social media posts about Episode 5 * leave a review on any of the podcast platforms * Send me your honest thoughts about the show and what I can do to improve it (ringsabellpodcast@gmail.com [ringsabellpodcast@gmail.com]) * Spread the show through word of mouth to a colleague or a friend and then let me know so I can add you to the draw ALL THE LINKS! Find all the links to all the things (references, resources, buy me a coffee, email list, etc) here: https://ringsabellpod.kit.com/allthethings  ---------------------------------------- Hosted on Acast. See acast.com/privacy [https://acast.com/privacy] for more information.

Episode 4: Anemia with Jenny Hsieh

Episode 4 provides - A refresher on how red blood cells are formed, their lifecycle and inputs - An overview of the major types of anemia classified by pathophysiology and histology (how the red blood cells look under a slide) - Some simple physical symptoms that pharmacists can look for in practice and what they might indicate - A refresher on the major guidelines for iron deficiency anemia including a recent update - Some excellent case studies detailing the complexity of dealing with patients who have chronic inflammation AND anemia - New this episode: some semi-useful notes in pdf form from me to you. Merry Christmas ya bunch of hooligans! Links: Find all the links to all the things here: https://ringsabellpod.kit.com/allthethings Find Jenny at: https://www.linkedin.com/in/jenny-hsieh-435828177/ References: See all the links above. ---------------------------------------- Hosted on Acast. See acast.com/privacy [https://acast.com/privacy] for more information.

Episode 3 Part 1: Metabolic Health with Dr. Alex Nataros

Keywords: insulin sensitivity, metformin, blood sugar management, dietary approaches, microbiome, GLP-1 agonists, functional medicine, probiotics, metabolic health, clinical signs Summary: Episode 3 part 1 covers general metabolic health as it relates to pharmaceuticals, the microbiome and nutrition. My guest is Dr. Alex Nataros, a family doctor practicing in Port Hardy, BC. Subscribe to the Rings a Bell email list here: https://ringsabellpod.kit.com/subscribe To become a guest on the show email ringsabellpodcast@gmail.com References: Weight Gain Drugs https://pmc.ncbi.nlm.nih.gov/articles/PMC6109660/ Weight loss drugs https://mobile.fpnotebook.com/Endo/Pharm/MdctnsAsctdWthUntntnlWghtLs.htm [https://mobile.fpnotebook.com/Endo/Pharm/MdctnsAsctdWthUntntnlWghtLs.htm] Insulin Sensitivity Drugs Giglio RV, Papanas N, Rizvi AA, Ciaccio M, Patti AM, Ilias I, Pantea Stoian A, Sahebkar A, Janez A, Rizzo M. An Update on the Current and Emerging Use of Thiazolidinediones for Type 2 Diabetes. Medicina. 2022; 58(10):1475. https://doi.org/10.3390/medicina58101475 [https://doi.org/10.3390/medicina58101475] Laurindo LF, Barbalho SM, Guiguer EL, da Silva Soares de Souza M, de Souza GA, Fidalgo TM, Araújo AC, de Souza Gonzaga HF, de Bortoli Teixeira D, de Oliveira Silva Ullmann T, et al. GLP-1a: Going beyond Traditional Use. International Journal of Molecular Sciences. 2022; 23(2):739. https://doi.org/10.3390/ijms23020739 https://doi.org/10.1016/j.redox.2020.101517 [https://doi.org/10.1016/j.redox.2020.101517] (Mechanisms of Action of metformin in type 2 diabetes: effects on mitochondria and leukocyte endothelium interactions. Microbiome and obesity:  https://doi.org/10.1016/j.biopha.2022.112678 [https://doi.org/10.1016/j.biopha.2022.112678] Sohail MU, Althani A, Anwar H, Rizzi R, Marei HE. Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus. J Diabetes Res. 2017;2017:9631435. doi:10.1155/2017/9631435 HMF Metabolic: Michael DR, Jack AA, Masetti G, et al. A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being. Sci Rep. 2020;10(1):4183. Published 2020 Mar 6. doi:10.1038/s41598-020-60991-7 UltraFlora Control: Stenman LK, Lehtinen MJ, Meland N, et al. Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial. EBioMedicine. 2016;13:190-200. doi:10.1016/j.ebiom.2016.10.036 Super intense study on personalized nutrition published in cell that I talked too long about :) Zeevi D, Korem T, Zmora N, et al. Personalized Nutrition by Prediction of Glycemic Responses. Cell. 2015;163(5):1079-1094. doi:10.1016/j.cell.2015.11.001                 ---------------------------------------- Hosted on Acast. See acast.com/privacy [https://acast.com/privacy] for more information.

Episode 2 - Constipation with Shelley Stepanuik

REFERENCES FROM SHELLEY: - UpToDate as referenced summer 2025   - RxFiles 2023 edition   - Bristol Stool Chart   - probioticchart.ca [http://probioticchart.ca/]   - Why you should be careful with psyllium husk fiber supplement. YouTube:  https://youtu.be/mPHXldh4_H4?si=wtAMhpP2QDCxPlr6 [https://youtu.be/mPHXldh4_H4?si=wtAMhpP2QDCxPlr6]   - Cascara Sagrada withdrawal in USA https://www.fda.gov/about-fda/fda-history-exhibits/drug-therapeutics-regulation-us# [https://www.fda.gov/about-fda/fda-history-exhibits/drug-therapeutics-regulation-us]   - Phenothalein withdrawal from market https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/phenolphthalein# [https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/phenolphthalein]   - Bisacodyl  Neurogastroenterol Motil. 2021 Mar 9;33(10):e14123. doi: 10.1111/nmo.14123   Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation   Maura Corsetti 1,2,, Sabine Landes 3, Robert Lange 4 PMCID: PMC8596401 PMID: 33751780 https://pmc.ncbi.nlm.nih.gov/articles/PMC8596401/ [https://pmc.ncbi.nlm.nih.gov/articles/PMC8596401/]   - Stimulant laxatives    First published online June 16, 2024 Review article: do stimulant laxatives damage the gut? A critical analysis of current knowledge Peter Whorwell https://orcid.org/0000-0002-5220-8474 [https://orcid.org/0000-0002-5220-8474] peter.whorwell@mft.nhs.uk [peter.whorwell@mft.nhs.uk], Robert Lange, and Carmelo Scarpignato    https://doi.org/10.1177/17562848241249664 [https://doi.org/10.1177/17562848241249664]   - Rhubarb  https://pmc.ncbi.nlm.nih.gov/articles/PMC8321582/# [https://pmc.ncbi.nlm.nih.gov/articles/PMC8321582/]   - Demulcents https://www.sciencedirect.com/topics/neuroscience/demulcent# [https://www.sciencedirect.com/topics/neuroscience/demulcent] [data:image/gif;base64,R0lGODdhAQABAJEAAAAAAP///wAAAAAAACH5BAkAAAIALAAAAAABAAEAAAICVAEAOw==]   REFERENCES FROM KIM: Lexicomp drug information for: podophyllum, wheat dextrin, phenolpthalein, polyethylene glycol 3350 https://time.com/archive/6617019/medicine-cut-out-the-liver/ [https://time.com/archive/6617019/medicine-cut-out-the-liver/] * Pharmacology, toxicology, clinical efficacy, and adverse effects of calcium polycarbophil, an enteral hydrosorptive agent. PMID: 6765389 ---------------------------------------- Hosted on Acast. See acast.com/privacy [https://acast.com/privacy] for more information.