Brave New World

In today’s episode, Evgeny Lebedev talks about the remarkable potential of ketamine with Dr John Krystal, Professor of neuroscience at the Yale School of Medicine.  Their discussion delves into the world of neurology, what ketamine actually does to our brain and the importance of glutamate receptors in treating depression. Ketamine may have gotten bad press after Friends actor Matthew Perry died of an overdose while receiving treatment with the drug, but for Dr Krystal, it is a critically overlooked solution to the epidemic of mental illness. Also in this episode: * Ketamine’s complicated history starting in the 1950s * The real reason depression leads to suicide * Why ketamine is effective at dealing with trauma * The detailed procedure of ketamine therapy  * The importance of ketamine’s “narrow window” dosage * Ketamine’s reputation and why it needs to change ---------------------------------------- Hosted on Acast. See acast.com/privacy [https://acast.com/privacy] for more information.

In today’s episode, we are excited to be joined by Peter Attia: a longevity expert, physician, and bestselling author.   Peter’s podcast, The Drive, is one of the most popular in the world. Through it, he’s brought cutting edge science to the masses, sharing tips and tricks, some of which are still experimental, on how to boost your chances of ageing well.   Tune into Peter and Evgeny’s conversation on what the former calls “Medicine 3.0” — his blueprint for good health — and how happiness is essential to longevity, not just a bonus. “It doesn’t matter how healthy you are,” Peter says, “if the most important relationships in your life are not happy.”   Topics covered include:  * The difference between health span and lifespan * How AI can revolutionise clinical trials and the development of new medicines  * ⁠How to regulate glucose levels * Tips to reducing caloric intake * Why cancer immunity is under-researched * How to prevent heart disease * ⁠Debunking the biggest myths around nutrition ---------------------------------------- Hosted on Acast. See acast.com/privacy [https://acast.com/privacy] for more information.

Evgeny Lebedev joins Dr. Aubrey de Grey, a visionary in biomedical gerontology and co-founder of the SENS Research Foundation. Known for his radical approach to ageing, Dr. de Grey discusses why some need to awaken from a "pro-ageing trance". What’s Aubrey’s biological age? In this episode: * Why we don’t “have” to age * Reversing cellular aging * The ethical questions surrounding life extension * The societal shifts we might expect if ageing becomes a treatable condition * The science behind extending the human healthspan Plus more. ---------------------------------------- Hosted on Acast. See acast.com/privacy [https://acast.com/privacy] for more information.

On today’s show Evgeny Lebedev is in conversation with the Oscar-winning actor, Dame Helen Mirren. They discuss everything from the evolution of fashion to the contemporary media landscape. “It’s so sad that Kurt Cobain died when he did, because he never got to see GPS” Also in this episode: * The evolution of technology and why Helen is grateful to have been around in a world without it * How young people rediscover previously forgotten tech and bring it back to life * Helen reflects on spirituality, the power of belief and how it shapes our lives, but why she doesn't believe in God. * Russian heritage and the complexities of her identity * How Helen stays youthful, both in body and mind ---------------------------------------- Hosted on Acast. See acast.com/privacy [https://acast.com/privacy] for more information.

Evgeny Lebedev is joined by Jim Poole, chairman, president and chief executive of neuroscience company Solace Life Sciences. The company owns NuCalm, a technology designed to reduce stress and improve sleep without recourse to drugs. You may have even spotted the Duchess of Sussex wearing one of their stress relief patches. In this episode, Evgeny and Jim explore the evolution of the human brain, anxiety and how to deregulate the amygdala, a small, almond-shaped part of the brain that plays a central role, which Jim says ‘feeds on fear’.   In this episode: * The current state of brain understanding * Brain psychology and its evolution * The autonomic nervous system and how it shapes everything from stress to relaxation * Ho to control anxious thoughts * How to downregulate the amygdala, the part of the brain that triggers intense fear responses * Different frequencies in the brain and how they influence mental states * Why “the Western world may be leading the cause” of anxiety ---------------------------------------- Hosted on Acast. See acast.com/privacy [https://acast.com/privacy] for more information.