GLP-1 Weight Loss Drugs Explained: Ozempic, Wegovy & Mounjaro - Results, Side Effects and Long-Term Risks

End of Season 1

Just me Tim Quin, saying a huge thank you for listening to the podcast throughout this first season of Quest For Longevity. I hope it has helped you discover new ways to stay healthy, stay active and live longer. Some big changes to the format of the podcast coming in season 2 and I hope you'll join me to experience them. Listen to this episode and I'll tell you all about what's coming. Social Channels Threads: https://www.threads.com/@timquin0 [https://www.threads.com/@timquin0] WhatsApp: https://whatsapp.com/channel/0029Vb7jPjNCRs1kXPBMz341 [https://whatsapp.com/channel/0029Vb7jPjNCRs1kXPBMz341] Facebook: https://www.facebook.com/QuestLongevity [https://www.facebook.com/QuestLongevity] X: https://x.com/timquin0 [https://x.com/TimQuin0] Instagram: https://instagram.com/timquin0 [https://instagram.com/@timquin0] TikTok: https://tiktok.com/timquin1 [https://tiktok.com/timquin1]

Activate Your Longevity Genes: Fight Disease, Slow Aging & Live Longer

Can you slow the aging process by activating your longevity genes? In this episode we break down the science behind six key longevity genes — including FOXO3, sirtuins, TERT, APOE, IGF-1, and CETP — and explain what they do inside your body. We then cover the evidence-backed lifestyle habits that activate them: zone 2 cardio, resistance training, intermittent fasting, sleep optimisation, stress reduction, and targeted supplementation including NMN, omega-3, and vitamin D. Whether you're new to longevity science or already invested in your healthspan, this episode gives you practical tools to start slowing biological aging today. Build your longevity knowledge: your next listen Chronic Inflammation: What it is, why it's bad, and what you can do to avoid it [https://podcasts.apple.com/us/podcast/chronic-inflammation-what-it-is-why-its-bad-and-what/id1824853211?i=1000733034143] Autophagy: Your Disease Fighting, Life-Extending Super Power [https://podcasts.apple.com/us/podcast/autophagy-your-disease-fighting-life-extending-super/id1824853211?i=1000735933279] Intermittent Fasting: What Is It, How Does It Work and Is It Right For You? [https://podcasts.apple.com/us/podcast/intermittent-fasting-what-is-it-how-does-it-work-and/id1824853211?i=1000723123397] The Mediterranean Diet Explained: How To Lose Weight & Get Healthy [https://podcasts.apple.com/us/podcast/the-mediterranean-diet-explained-how-to-lose-weight/id1824853211?i=1000747163983] Longevity Genes Research Sources FOXO3 and Longevity FOXO3A Genotype Is Strongly Associated with Human Longevity [https://www.pnas.org/doi/10.1073/pnas.0801030105] FOXO3 – A Major Gene for Human Longevity (PMC) [https://pmc.ncbi.nlm.nih.gov/articles/PMC5403515/] Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies [https://pmc.ncbi.nlm.nih.gov/articles/PMC6175020/] Sirtuins and NAD+ It Takes Two to Tango: NAD+ and Sirtuins in Aging/Longevity Control [https://www.nature.com/articles/npjamd201617] NAD+ and Sirtuins in Aging and Disease (NIH/PMC) [https://pmc.ncbi.nlm.nih.gov/articles/PMC4112140/] Sirtuins and Their Biological Relevance in Aging and Age-Related Diseases [https://pmc.ncbi.nlm.nih.gov/articles/PMC7390530/] Telomeres, TERT and Exercise Exercise Delays Aging: Evidence from Telomeres and Telomerase [https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1627292/full] Physical Activity and Telomere Length: Impact of Aging and Potential Mechanisms [https://pmc.ncbi.nlm.nih.gov/articles/PMC5546536/] Telomeres, Lifestyle, Cancer, and Aging (NIH/PMC) [https://pmc.ncbi.nlm.nih.gov/articles/PMC3370421/] Stress, Mindfulness and Telomere Length Can Meditation Slow Rate of Cellular Aging? Cognitive Stress, Mindfulness, and Telomeres (PMC) [https://pmc.ncbi.nlm.nih.gov/articles/PMC3057175/] Wandering Minds and Aging Cells – Epel, Blackburn et al. [https://journals.sagepub.com/doi/10.1177/2167702612460234] IGF-1, Fasting and Protein Protein Quantity and Source, Fasting-Mimicking Diets, and Longevity (NIH/PMC) [https://pmc.ncbi.nlm.nih.gov/articles/PMC6855936/] Fasting-Mimicking Diet and Markers/Risk Factors for Aging, Diabetes, Cancer, and Cardiovascular Disease [https://pmc.ncbi.nlm.nih.gov/articles/PMC6816332/] Mediterranean Diet The Mediterranean Diet and Cardiovascular Health – Circulation Research [https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.313348] Long-Term Impact of Mediterranean Diet on Cardiovascular Disease Prevention – PubMed [https://pubmed.ncbi.nlm.nih.gov/38431146/] Inflammaging Chronic Inflammation and the Hallmarks of Aging (NIH/PMC) [https://pmc.ncbi.nlm.nih.gov/articles/PMC10359950/] Inflammageing: Chronic Inflammation in Ageing, Cardiovascular Disease, and Frailty [https://pmc.ncbi.nlm.nih.gov/articles/PMC6146930/] Inflammation and Aging: Signaling Pathways and Intervention Therapies – Nature [https://www.nature.com/articles/s41392-023-01502-8] Sleep and the Glymphatic System The Glymphatic System Clears Amyloid Beta and Tau from Brain to Plasma in Humans – Nature Communications [https://www.nature.com/articles/s41467-026-68374-8] The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices (PMC) [https://pmc.ncbi.nlm.nih.gov/articles/PMC7698404/] Social Channels Threads: https://www.threads.com/@timquin0 [https://www.threads.com/@timquin0] WhatsApp: https://whatsapp.com/channel/0029VbBpYR2Chq6NOqlcGT0T [https://whatsapp.com/channel/0029VbBpYR2Chq6NOqlcGT0T] Facebook: https://www.facebook.com/TimothyQuin [https://www.facebook.com/TimothyQuin] X: https://x.com/timquin0 [https://x.com/TimQuin0] Instagram: https://instagram.com/timquin0 [https://instagram.com/@timquin0] TikTok: https://tiktok.com/timquin1 [https://tiktok.com/timquin1]

GLP-1 Weight Loss Drugs Explained: Ozempic, Wegovy & Mounjaro - Results, Side Effects and Long-Term Risks

GLP-1 weight loss drugs like Ozempic, Wegovy and Mounjaro are transforming obesity treatment. But how do GLP-1 injections actually work? How much weight can you lose, what are the side effects, how much do they cost, and what happens when you stop taking semaglutide? In this episode we examine the evidence behind GLP-1 medications, their risks, benefits and long-term impact on health. Common GLP-1 Weight Loss Drug Questions Answered in This Episode * What are GLP-1 and GIP drugs and what are they doing inside my body? * How much weight could I lose on GLP-1 drugs? * What are the benefits of taking GLP-1 drugs? * What are the risks of taking GLP-1 medication? * Will GLP-1 injections cause my muscles to waste? * How much do GLP-1 drugs cost? * Should I take GLP-1 weight loss drugs? Weight Loss Drugs – Timestamps 00:00 – Do you struggle to lose weight? 03:55 – Common questions about weight loss drugs 05:31 – What are GLP-1 drugs and how do they work? 08:25 – How much weight could I lose on weight loss jabs? 11:47 – What are the risks of taking GLP-1 weight loss drugs? 13:53 – Can GLP-1 weight loss injections cause muscle wastage? 17:29 – Should I take GLP-1 weight loss drugs? 19:08 – What happens when I stop taking GLP-1 weight loss medication? 20:33 – How much do GLP-1 weight loss jabs cost? 22:24 – The future of weight loss medication 24:25 – GLP-1 weight loss drugs summary GLP-1 Weight Loss Drugs Research Sources How GLP-1 Drugs Work & Clinical Effectiveness Once-Weekly Semaglutide in Adults with Overweight or Obesity — New England Journal of Medicine [https://www.nejm.org/doi/full/10.1056/NEJMoa2032183] Semaglutide for the Treatment of Overweight and Obesity: A Review — PMC [https://pmc.ncbi.nlm.nih.gov/articles/PMC10092086/] Cardiovascular & Kidney Benefits Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT Trial) — New England Journal of Medicine [https://www.nejm.org/doi/full/10.1056/NEJMoa2307563] Clinical Outcomes of Tirzepatide or GLP-1 Receptor Agonists in Individuals With Type 2 Diabetes — PMC/JAMA Network Open [https://pmc.ncbi.nlm.nih.gov/articles/PMC11320168/] Tirzepatide Slowed Progression of Chronic Kidney Disease in Patients with Type 2 Diabetes — American Diabetes Association [https://diabetes.org/newsroom/tirzepatide-slowed-progression-chronic-kidney-disease-pateints-with-type-2-diabetes-increased-cardiovascular-disease] Side Effects & Safety Considerations and Interactions with GLP-1 Receptor Agonists — NHS Specialist Pharmacy Service [https://www.sps.nhs.uk/articles/considerations-and-interactions-with-glp-1-receptor-agonists/] GLP-1 Agonists — Diabetes UK [https://www.diabetes.org.uk/about-diabetes/looking-after-diabetes/treatments/tablets-and-medication/glp-1] Weight-Loss Injections Explained — British Heart Foundation [https://www.bhf.org.uk/informationsupport/heart-matters-magazine/medical/weight-loss-injections-explained] Muscle Loss & Sarcopenia Muscle Mass and GLP-1 Receptor Agonists: Adaptive or Maladaptive Response to Weight Loss? — Circulation (AHA) [https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.067676] Changes in Lean Body Mass with GLP-1-Based Therapies and Mitigation Strategies — PubMed [https://pubmed.ncbi.nlm.nih.gov/38937282/] Impact of GLP-1 Receptor Agonist Therapy in Patients High Risk for Sarcopenia — PubMed [https://pubmed.ncbi.nlm.nih.gov/40289060/] Weight Regain After Stopping Weight Regain and Cardiometabolic Effects After Withdrawal of Semaglutide: The STEP 1 Trial Extension — PMC [https://pmc.ncbi.nlm.nih.gov/articles/PMC9542252/] New Study Finds Stopping Weight-Loss Drugs Is Linked to Faster Regain Than Ending Diet Programmes — University of Oxford [https://www.ox.ac.uk/news/2026-01-08-new-study-finds-stopping-weight-loss-drugs-linked-faster-regain-ending-diet] Fake & Counterfeit Drugs Warning About Sharp Rise in Illegal Medicines Sold in the EU — European Medicines Agency [https://www.ema.europa.eu/en/news/warning-about-sharp-rise-illegal-medicines-sold-eu] Fake Ozempic: WHO Warns of Falsified Semaglutide Sold Online — Medical News Today [https://www.medicalnewstoday.com/articles/fake-ozempic-semaglutide-pens-hospitalizations-severe-sde-effects] WHO Recognition of Obesity as a Chronic Disease & GLP-1 Guidance WHO Issues Global Guideline on the Use of GLP-1 Medicines in Treating Obesity [https://www.who.int/news/item/01-12-2025-who-issues-global-guideline-on-the-use-of-glp-1-medicines-in-treating-obesity] Social Channels WhatsApp: https://whatsapp.com/channel/0029VbBpYR2Chq6NOqlcGT0T [https://whatsapp.com/channel/0029VbBpYR2Chq6NOqlcGT0T] Facebook: https://www.facebook.com/TimothyQuin [https://www.facebook.com/TimothyQuin] X: https://x.com/timquin0 [https://x.com/TimQuin0] Instagram: https://instagram.com/timquin0 [https://instagram.com/@timquin0] YouTube: https://youtube.com/timquin0 [https://youtube.com@timquin0] TikTok: https://tiktok.com/timquin1 [https://tiktok.com/timquin1]

Is Your Coffee Toxic? - The Truth About Mycotoxins & Coffee

Is Your Coffee Making You Sick? - The Truth About Mycotoxins in Coffee You've probably seen the hype — "mouldy coffee," "toxic beans," "your morning cup is slowly poisoning you." But is there any truth to it, or is it just clever marketing designed to sell you expensive "clean" coffee? In this episode, we cut through the noise and take an evidence-based look at mycotoxins in coffee. We cover what mycotoxins actually are, why ochratoxin A (OTA) and aflatoxins keep coming up, and what independent studies really show about contamination levels in green, roasted, and instant coffee. We also look at what happens during roasting and brewing — and why the mould found on raw coffee beans tells a very different story to what ends up in your cup. Plus, how EU food safety regulations and maximum limits for ochratoxin A apply to the coffee you buy every day, and whether low-mycotoxin or mould-free coffee is worth the premium. If you're a health-conscious coffee drinker wondering whether to switch brands, ditch instant, or invest in specialty coffee, this episode gives you the practical, no-hype breakdown you need. You'll learn the following about mycotoxins and coffee * What mycotoxins are and how they form on coffee beans * Whether roasting destroys mycotoxins * How your total dietary mycotoxin load matters more than coffee alone * Simple storage tips to keep your coffee as clean as possible Mycotoxin-Free Coffee Suppliers The truth about mycotoxins in coffee. Do we really need to avoid them? [https://exhalecoffee.com/blogs/news/mycotoxins-in-coffee-do-we-really-need-to-avoid-them] Organic Coffee Beans (Lab-tested, Mould & Chemical Free) [https://balancecoffee.co.uk/collections/organic-coffee-beans] Focus | Organic Coffee Beans | Mycotoxin Free - Lab Tested | Freshly Roasted [https://mindfulcoffee.co.uk/products/mindful-coffee-focus-speciality-grade-freshly-roasted-coffee-beans-organic-and-fairtrade-mycotoxin-free] Mycotoxin Free Coffee: How the Mule keeps your beans clean [https://grumpymule.co.uk/blogs/news/mycotoxin-free-coffee?srsltid=AfmBOoo6OVimLLz3Air2QJpJvAjUatXW7tJ2nw83dG2KSFtph-G4LwbZ] Organic Coffee, Mycotoxin Free Clean & Pure | Lean caffeine [https://leancaffeine.co.uk/collections/coffee] Bulletproof Coffee & Mycotoxins | Big Island Coffee Roasters [https://bigislandcoffeeroasters.com/blogs/blog/bulletproof-proof-coffee-mycotoxin] Research Sources: Mycotoxins & Coffee Prevalence of toxigenic fungi and mycotoxins in Arabic coffee (Coffea arabica): Protective role of traditional coffee roasting, brewing and bacterial volatiles - PMC [https://pmc.ncbi.nlm.nih.gov/articles/PMC8555823/] Mycotoxins in green coffee: Occurrence and risk assessment - ScienceDirect [https://www.sciencedirect.com/science/article/abs/pii/S0956713518304420] Mycotoxins | EFSA [https://www.efsa.europa.eu/en/topics/topic/mycotoxins] Prevalence of toxigenic fungi and mycotoxins in Arabic coffee (Coffea arabica): Protective role of traditional coffee roasting, brewing and bacterial volatiles | PLOS One [https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0259302] Social Channels WhatsApp: https://whatsapp.com/channel/0029VbBpYR2Chq6NOqlcGT0T [https://whatsapp.com/channel/0029VbBpYR2Chq6NOqlcGT0T] Facebook: https://www.facebook.com/TimothyQuin [https://www.facebook.com/TimothyQuin] X: https://x.com/timquin0 [https://x.com/TimQuin0] Instagram: https://instagram.com/timquin0 [https://instagram.com/@timquin0] TikTok: https://tiktok.com/timquin1 [https://tiktok.com/timquin1]

The 90 Minute Coffee Rule: Why You Shouldn't Drink Coffee First Thing In The Morning

Why You Should Wait 90 Minutes Before Drinking Coffee In The Morning Are you struggling with that mid-afternoon energy crash? In this episodeI look into the science of caffeine timing and why reaching for your morning coffee the moment you wake up might be sabotaging your focus and energy levels. We dive into the "90-minute rule" to explain how delaying your first cup helps align with your body's natural cortisol levels and circadian rhythm. You'll learn how adenosine build-up causes that dreaded afternoon slump and I share some simple morning hacks to boost your natural energy without caffeine first thing. Key Caffeine Takeaways: * The link between cortisol spikes and caffeine tolerance. * How to clear adenosine naturally to prevent a midday slump. * Practical tips for staying alert before your first brew. Stop the cycle of caffeine crashes and optimize your energy. This one hack might transform your energy levels! 90 Minute Coffee Delay Research Sources Source articles I referenced to help produce this episode about delaying your morning coffee: * Huberman Lab: Caffeine Science and Timing Strategies [https://www.hubermanlab.com] * Houston Methodist: Is There a Best Time to Drink Your Coffee? [https://www.houstonmethodist.org] * PMC: Caffeine Stimulation of Cortisol Secretion [https://pmc.ncbi.nlm.nih.gov] * ScienceDaily: Drink Coffee After Breakfast, Not Before [https://www.sciencedaily.com] * Oura Ring: Should You Delay Your Morning Caffeine? [https://ouraring.com] * News-Medical: Caffeine Timing Guide [https://www.news-medical.net] Social Channels WhatsApp: https://whatsapp.com/channel/0029VbBpYR2Chq6NOqlcGT0T [https://whatsapp.com/channel/0029VbBpYR2Chq6NOqlcGT0T] Facebook: https://www.facebook.com/TimothyQuin [https://www.facebook.com/TimothyQuin] X: https://x.com/timquin0 [https://x.com/TimQuin0] Instagram: https://instagram.com/timquin0 [https://instagram.com/@timquin0] YouTube: https://youtube.com/timquin0 [https://youtube.com@timquin0] TikTok: https://tiktok.com/timquin1 [https://tiktok.com/timquin1]