SHTG Digest — Tuesday June 2, 2026

SHTG Digest — Tuesday June 9, 2026

A sweeping 25-year review of lipid medicine published today in *Lancet Diabetes & Endocrinology* maps the journey from statins to RNA/DNA-targeted therapies for APOC3 and ANGPTL3; on the industry side, it's a quiet news week, but the Ionis FDA clock for Tryngolza in severe hypertriglyceridemia is now ticking down to a June 30 decision.

SHTG Digest — Friday June 5, 2026

Circulation Research publishes a landmark trio of review articles on triglyceride-rich lipoprotein biology and RNA-targeted therapies today, while on the industry side it is a quiet week — but the Ionis Tryngolza FDA decision in sHTG is now just 25 days away and Arrowhead's SHASTA-3/4 phase 3 readouts are imminent.

SHTG Digest — Tuesday June 2, 2026

A PNAS study reveals GPIHBP1 on brain oligodendrocytes as a novel docking site for LPL in the CNS, while an updated meta-analysis consolidates olezarsen's case as a potent APOC3-targeting therapy; on the industry side, a quiet week ahead of Ionis' looming June 30 FDA decision for Tryngolza in sHTG.

SHTG Digest — Friday May 29, 2026

A quiet week on top-tier journal lipid papers, but four solid next-tier publications span plozasiran's approval story, a machine-learning breakthrough for predicting which HTG patients will develop pancreatitis, lipidomic signatures of drug-refractory HTG, and pediatric monogenic HTG genetics; on the industry side, Ionis's platform scores a landmark hepatitis B win this week, keeping the ASO powerhouse in the spotlight while its Tryngolza sHTG approval decision looms by June 30.

SHTG Digest — Tuesday May 26, 2026

A landmark Circulation imaging trial finds that olezarsen's dramatic triglyceride lowering does not translate into coronary plaque regression at 12 months—raising fundamental questions about TG-lowering as an atherosclerosis therapy just as the 2026 ACC/AHA dyslipidemia guideline reframes how we should think about hypertriglyceridemia, and with Ionis's PDUFA date for the SHTG indication just five weeks away.