The Rx Chronicles

Product of the Century: Story of Fluoxetine

In all the research into Prozac's history, one thing stood out that has never appeared with any other invention: gratitude so intense, so personal, that multiple people—strangers to each other—independently said they wanted to kiss its inventor. The light bulb changed civilization, yet no one ever wanted to embrace Edison. Penicillin saved millions, but Fleming never inspired that kind of affection. What made Prozac different? ------------------------------------------ References: 1. Ray W. Fuller, David T. Wong, and Bryan B. Molloy - The archive of Science History Institute (Museum and Library) 2. The Story of Prozac: A Landmark Drug in Psychiatry - Psychology Today 3. Klaus Schmiegel (Prozac). Lemelson-MIT Program (LMIT) ------------------------------------------ Music: Sourced from Pixabay Produced by: Radin Alikhani Instagram: @rxchronicles_

Episode 04: Pfizer's Crown Jewel - Bruce Roth

In a crowded field of cholesterol drugs, one scientist’s bold discovery quietly rewrote the rules of medicine and business. ------------------------------------------ References: 1. Li, Jie Jack, 'Discovery of Lipitor', Triumph of the Heart: The Story of Statins (New York, 2009; online edn, Oxford Academic, 12 Nov. 2020), https://doi.org/10.1093/oso/9780195323573.003.0010 [https://doi.org/10.1093/oso/9780195323573.003.0010] 2. A Star in His Own Right. Dec 13, 2o16. https://www.gene.com/stories/a-star-in-his-own-right [https://www.gene.com/stories/a-star-in-his-own-right] ------------------------------------------ Music: Sourced from Pixabay and Udio Produced by: Radin Alikhani Instagram: @rxchronicles_ ------------------------------------------ Special thanks to the University of Michigan's Shapiro Library for providing the recording space for this episode.

Episode 03: Insulin's Birth - Banting & Best

From a bitter Nobel Prize dispute to the fragile partnerships that nearly unraveled it all, this is the untold human drama behind insulin. A story marked by clashing egos, secret experiments, and credit denied, the path to this life-saving breakthrough was anything but straightforward. ------------------------------------------ References: 1. The Discovery and Early Development of Insulin - University of Toronto Libraries 2. The discovery of insulin: a story of monstrous egos and toxic rivalries. By Kersten Hall 3. Frederick Banting, Charles Best, James Collip, and John Macleod - The archive of Science History Institute (Museum and Library) ------------------------------------------ Music: Sourced from Pixabay and Udio Produced by: Radin Alikhani Instagram: @rxchronicles_ ------------------------------------------ Special thanks to the University of Michigan's Shapiro Library for providing the recording space for this episode.

Episode 02: The Water Pill Revolution - Karl Beyer Jr

Before the applause, there was resistance. Before the prize, uncertainty. Four names. One forgotten moment. A quiet revolution in medicine that changed the course of cardiovascular care—forever. This episode begins with a voice from 1975 and unfolds into something much bigger... ------------------------------------------ References: 1. National Academy of Sciences. Biographical Memoirs: By Garabed Eknoyan. Washington, DC: The National Academies Press. 2. Beyer KH Jr (1977). Discovery of the thiazides: where biology and chemistry meet. Perspectives in biology and medicine, 20(3), 410–420. https://doi.org/10.1353/pbm.1977.0048 [https://doi.org/10.1353/pbm.1977.0048] 3. Drugs.com [http://Drugs.com] - Hydrochrolothiazide Patient Tips ------------------------------------------ Music: Sourced from Pixabay and Udio Produced by: Radin Alikhani Instagram: @rxchronicles_ ------------------------------------------ Special thanks to the University of Michigan's Shapiro Library for providing the recording space for this episode.

Episode 01: The Mood Metal - John Cade

Lithium was once just a remedy for gout and bladder stones—until a psychiatrist’s bizarre experiment changed everything. After World War II, John Cade injected urine from mentally ill patients into guinea pigs, hoping to uncover the biological roots of mental illness... ------------------------------------------ References: 1. Cade J. F. (1999). John Frederick Joseph Cade: family memories on the occasion of the 50th anniversary of his discovery of the use of lithium in mania. 1949. The Australian and New Zealand journal of psychiatry, 33(5), . https://doi.org/10.1080/j.1440-1614.1999.00624.x [https://doi.org/10.1080/j.1440-1614.1999.00624.x] 2. Shorter E. (2009). The history of lithium therapy. Bipolar disorders, 11 Suppl 2(Suppl 2), 4–9. https://doi.org/ [https://doi.org/]10.1111/j.1399-5618.2009.00706.x 3. Chiu, E., & Hegarty, R. M. (1999). John Cade: the man. The Australian and New Zealand journal of psychiatry, 33 Suppl, S24–S26. https://doi.org/10.1111/j.1440-1614.1999.00664.x [https://doi.org/10.1111/j.1440-1614.1999.00664.x] 4. Draaisma, D. (2019). The serendipitous story of lithium. Nature, 572(7771), 584-585. doi:https://doi.org/10.1038/d41586-019-02480-0 [https://doi.org/10.1038/d41586-019-02480-0] 5. Drugs.com - Lithium Patient Tips ------------------------------------------ Music: Sourced from Pixabay and Musopen Produced by: Radin Alikhani Instagram: @rxchronicles_ ------------------------------------------ Special thanks to the University of Michigan's Shapiro Library for providing the recording space for this episode.