Dr. M’s SPA Newsletter Volume 16 Issue 12 – Creatine and Microbiomes

Dr. M’s SPA Newsletter Volume 16 Issue 18 – Autism and Microbiomes

Autism and Diagnosis Metabolites and Phenotypes In a brand new paper entitled. “Elevated Microbially-Derived Metabolites in Autism: A Possible Diagnostic Screening Test for a Distinct ASD Phenotype,” Dr. Flynn and colleagues investigated whether specific urinary metabolites produced by intestinal microbes could serve as predictive biomarkers for autism spectrum disorder. The study proposes that a large subset of children with autism may represent a biologically distinct phenotype characterized by markedly elevated microbial metabolites, which the authors term ASD-MDM (Autism Spectrum Disorder associated with Microbially-Derived Metabolites). The investigators analyzed urine samples from 52 children with ASD and 47 typically developing (TD) controls, ages 2–11 years. They measured microbial metabolites derived primarily from phenylalanine metabolism, tryptophan metabolism, and yeast metabolism. These were chosen because decades of autism, microbiome, and metabolic research have repeatedly implicated abnormalities in microbial metabolism of aromatic amino acids, especially phenylalanine and tryptophan, along with evidence of elevated fungal/yeast metabolites in subsets of children with ASD. The findings were striking. Children with ASD demonstrated significantly higher concentrations of many microbial metabolites than controls. Some metabolites were elevated by hundreds to thousands of percent, and in certain children concentrations were reported to be 100–1000 times higher than the highest levels observed in any control participant. Twenty-three of twenty-four measured microbial metabolites were higher in ASD participants. Ninety percent of the ASD participants (45 of 50) had one or more extremely elevated MDMs. Particularly notable were elevations in compounds related to p-cresol, p-cresol sulfate, phenylacetylglutamine, indole derivatives, and arabinitol, suggesting abnormalities in microbial metabolism involving aromatic amino acids and yeast overgrowth.... Also, Inflammation and Allergy. Enjoy, Dr. M

Dr. M’s SPA Newsletter Volume 16 Issue 17 – Processing Death

DEATH or Better Yet, Live for Today Recently, there has been more death and morbidity in my life than usual. There is no easy way to discuss this topic. Death is finite and simultaneously infinitely painful for the survivors. Everyone learns in the moment how to deal with death. There is no on-the-job training. We are not born ready to accept this reality. It is simply thrust upon us. While I deal with illness and death more frequently than the average American, an occupational reality, it never becomes easy. Each loss has its own weight. Each reminds us of truths we would rather not face. I found myself sitting quietly with these recent events and wondering what I would want for myself and my family if this had happened to me today. What would I have wanted for my friends and family if I had died at 17? At 35? At 55? What words would I say to my parents if I could speak to them one final time? What would I want my children to know? What would I hope my friends remembered? As these thoughts swirled in the sadness of loss, I kept returning to one simple idea: Live every day as if it could be your last, with honor and respect for yourself and others..... Dr. M

Dr. M’s Women and Children First Podcast #114: Aimie Apigian, MD – Biology of Trauma

Today's podcast guest is Dr. Aimie Apigian, a physician who has become one of the leading voices in helping us understand the biology of trauma. Dr. Aimie is double board-certified in Preventive Medicine and Addiction Medicine, with advanced training in biochemistry, public health, and functional medicine. She earned her medical degree from Loma Linda University, where her education also included behavioral health, child psychiatric therapy, play therapy, and addiction family counseling. Before medical school, she studied Cell and Molecular Biology at the University of Washington, where she worked in the laboratory of renowned cancer researcher Dr. Larry Loeb. She is the national bestselling author of The Biology of Trauma, featuring a foreword by Dr. Gabor Maté. The book has appeared on the USA TODAY Best-Selling Book List and has received multiple national book awards. What makes Dr. Aimie's work unique is her ability to bridge neuroscience, functional medicine, attachment science, and trauma therapy into a practical framework that explains how our bodies store survival patterns after stress and adversity. Rather than viewing trauma as simply a psychological experience, she teaches that it is a biological state—one that can be identified, measured, and, importantly, healed. She is the creator of the Biology of Trauma® framework, which integrates somatic therapies, parts work, nervous system regulation, and targeted biological interventions into a structured sequence designed to restore the body's innate capacity for healing. She is also the founder of Trauma Healing Accelerated™ and the host of the popular Biology of Trauma® Podcast, where she has educated thousands of clinicians and individuals around the world. Today, we're going to explore what trauma actually is from a biological perspective, how it influences immune function, metabolism, chronic disease, and childhood development, and perhaps most importantly, what it truly takes to move from surviving to thriving. Dr. M

Dr. M’s SPA Newsletter Volume 16 Issue 16 – Fake it Till You Make it

Fake It Till You Make It? One of the most misunderstood pieces of advice in our culture is the phrase "fake it until you make it." At face value, it sounds dishonest. It sounds like pretending to be something you are not. It sounds like confidence without competence. But after nearly three decades in medicine, I have come to believe there is a deeper truth hiding inside that phrase. Most success in life is not built on pretending. It is built on being willing to step into situations where you are not yet fully prepared, knowing that growth happens only when you are slightly or deeply beyond your comfort zone. If I am being honest, much of my professional life has felt this way, and the depth vacillated based on the context. When I finished my pediatric residency at the University of Virginia, I was 29 years old and knew just enough to realize how much I did not know. Medical school and residency provide an enormous foundation, but they also expose you to the staggering volume of knowledge that exists in the world. And that volume has only skyrocketed in the past 30 years. The farther I traveled in medicine, the more I realized the horizon kept moving, often unattainable. One experience from those early years remains crystal clear, almost like a scar from a wound. I had been asked to give a lecture to the pediatric residents at UVA on electrolyte solutions and exercise physiology. I spent time preparing and thought I knew the material reasonably well. I walked into the room feeling confident. Then the questions started..... and a literature review. Enjoy, Dr. M

Dr. M’s Women and Children First Podcast #113: Navaz Habib, DC – Vagal Action and Health

Welcome back to Dr. M’s Women and Children First. Today, we are joined by one of the leading voices in the world of vagus nerve health, functional medicine, and autonomic nervous system regulation, Dr. Navaz Habib. Dr. Habib is a chiropractor, educator, international speaker, and author of the bestselling books *Activate Your Vagus Nerve* and *Upgrade Your Vagus Nerve*. His work has helped bring the science of the vagus nerve from the research world into practical clinical medicine, helping providers and patients better understand the powerful connection between the brain, immune system, gut, metabolism, and overall health. On today's episode, we take a pediatric lens to this fascinating topic. We explore how vagal tone influences inflammation, stress resilience, digestion, sleep, emotional regulation, and neurodevelopment. We discuss what happens when the autonomic nervous system becomes dysregulated, how chronic stress can shape a child's physiology, and why the vagus nerve may be one of the most important communication highways in the body. We'll also dive into practical strategies that families and clinicians can use to support vagal function, including breathing techniques, movement, nutrition, social connection, sleep, and other evidence-informed interventions that can help children build greater resilience in an increasingly stressful world. If you've ever wondered how the nervous system intersects with immune health, behavior, gut function, and chronic disease risk, this conversation is for you. Please join me in welcoming Dr. Navaz Habib. Dr. M