Radiolab

Could puberty get any more awkward? Turns out, yes. Patrick Burleigh started going through puberty as a toddler. He had pubic hair before he was two years old and a mustache by middle school. All of this was thanks to a rare genetic mutation that causes testotoxicosis, also known as precocious puberty. From the moment he was born, abnormally high levels of testosterone coursed through his body, just as it had in his father’s body, his grandfather’s body, and his great-grandfather’s body. On this week’s episode, Patrick’s premature coming of age story helps us understand just why puberty is so awkward for all of us, and whether and how it helps forge us into the adults we all become. Special thanks to Craig Cox, Nick Burleigh, and Alyssa Voss at the NIH. EPISODE CREDITS: Reported by - Latif Nasserwith help from - Kelsey Padgett, Ekedi Fausther-Keeys, and Alyssa Jeong-PerryProduced by - Pat Walters, Alex Neason, and Alyssa Jeong-Perrywith help from - Ekedi Fausther-Keyeswith mixing help from - Arianne WackFact-checking by - Diane A. Kellyand Edited by  - Pat Walters   EPISODE CITATIONS: Articles - To read Patrick’s own writing about his experience with precocious puberty and to see photos of him as a child, check out his article in The Cut, “A 4-Year-Old Trapped in a Teenager’s Body” [https://www.thecut.com/2019/01/precocious-puberty-patrick-burleigh.html] (https://zpr.io/athKVQmtfzaN [https://zpr.io/athKVQmtfzaN]) In her spare time, our fact checker Diane Kelly is also a comparative anatomist, and you can hear her TEDMED talk, “What We Didn’t Know about Penis Anatomy [https://www.ted.com/talks/diane_kelly_what_we_didn_t_know_about_penis_anatomy/]” (https://zpr.io/MWHFTYBdubHj [https://zpr.io/MWHFTYBdubHj])  Our newsletter comes out every Wednesday. It includes short essays, recommendations, and details about other ways to interact with the show. Sign up [https://radiolab.org/newsletter] (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab [http://members.radiolab.org] (https://members.radiolab.org/) today. Follow our show on Instagram [http://instagram.com/radiolab], Twitter [http://twitter.com/radiolab] and Facebook [http://facebook.com/radiolab] @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org [radiolab@wnyc.org]. Leadership support for Radiolab’s science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

The definition of life is in flux, complexity is overrated, and humans are shrinking. Viruses are supposed to be sleek, pared-down, dead-eyed machines. But when one microbiologist stumbled upon a GIANT virus, hundreds of times bigger than any seen before, all that went out the window.  The discovery opened the door not only to a new cast of microscopic characters with names like Mimivirus, Mamavirus, and Megavirus, but also to basic questions: How did we miss these until now? Have they been around since the beginning? What if evolution could go … backwards? In this episode from 2015,  join former co-hosts Jad Abumrad and Robert Krulwich as they grill Radiolab regular Carl Zimmer on these paradoxical viruses – they’re so big that they can get their own viruses! - and what they can tell us about the nature of life.  Our newsletter comes out every Wednesday. It includes short essays, recommendations, and details about other ways to interact with the show. Sign up [https://radiolab.org/newsletter] (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab [http://members.radiolab.org] (https://members.radiolab.org/) today. Follow our show on Instagram [http://instagram.com/radiolab], Twitter [http://twitter.com/radiolab] and Facebook [http://facebook.com/radiolab] @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org [radiolab@wnyc.org]. Leadership support for Radiolab’s science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

In this episode we introduce you to a part of our bodies that was invisible to Western scientists until about five years ago; it’s called "the interstitium," a vast network of fluid channels inside the tissues around our organs that scientists have just begun to see, name, and understand. Along the way we look at how new technologies rub up against long-standing beliefs, and how millions of scientists and doctors failed to see what was right in front (and inside!) of their noses. We also find out how mapping the anatomy of this hidden infrastructure may help solve one of the fundamental mysteries of cancer, and perhaps provide a bridge between ancient and modern medicine.Special thanks to Aaron Wickenden, Jessica Clark, Mara Zepeda, Darryl Holliday, Dr. Amy Chang, Kate Sassoon, Guy Huntley, John Jacobson, Scotty G, and the Village Zendo EPISODE CREDITS -  Reported by - Lulu Miller and Jenn BrandelProduced by - Matt Kieltywith help from - Ekedi Fausther-Keeyswith mixing help from - Arianne WackFact-checking by - Natalie Middletonand Edited by  - Alex Neason EPISODE CITATIONS - Articles: Check out reporter Jenn Brandel’s companion essay to this episode in Orion magazine, titled, Invisible Landscapes [https://orionmagazine.org/article/interstitium-scientific-discovery-anatomy] (https://zpr.io/NKuxvYY84RvH [https://zpr.io/NKuxvYY84RvH]), which argues that the discovery of the interstitium could challenge established practices of compartmentalizing in science and society.Our newsletter comes out every Wednesday. It includes short essays, recommendations, and details about other ways to interact with the show. Sign up [https://radiolab.org/newsletter] (https://radiolab.org/newsletter)!Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab [http://members.radiolab.org] (https://members.radiolab.org/) today.Follow our show on Instagram [http://instagram.com/radiolab], Twitter [http://twitter.com/radiolab] and Facebook [http://facebook.com/radiolab] @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org [radiolab@wnyc.org]. Leadership support for Radiolab’s science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.