Neuroscience Daily: 5-minute briefing
Neuroscience Daily for 28 May follows 3 stories from r/neuro and r/neuroscience, moving through ketogenic neuroprotection, tongue touch mapping, nmda receptor gating. 1. Ketogenic Neuroprotection A new review in Translational Neurodegeneration argues that ketogenic diets remain one of the more plausible metabolic strategies for slowing neurodegenerative damage. The paper lays out several possible mechanisms, including giving neurons ketone bodies as an alternative fuel when glucose metabolism is impaired, while also reducing oxidative stress, calming inflammation, and affecting autophagy, protein aggregation, and the gut microbiome. Source link [https://link.springer.com/article/10.1186/s40035-026-00557-1] Reddit discussion [https://www.reddit.com/r/neuroscience/comments/1to5nxr/the_ketogenic_diet_may_protect_against_alzheimers/] 2. Tongue Touch Mapping A Nature paper looked at how mice re-aim their tongues when a water spout suddenly shifts position during licking, and it points to a surprisingly central role for the lateral superior colliculus. The researchers found that the animals used both touch feedback and tongue-position information to adjust the next lick in real time. Source link [https://www.nature.com/articles/s41586-024-08339-3] Reddit discussion [https://www.reddit.com/r/neuroscience/comments/1hrvqmp/a_collicular_map_for_touchguided_tongue_control/] 3. NMDA Receptor Gating A Neuron paper is giving researchers a much more detailed look at a tri-heteromeric NMDA receptor subtype called GluN1-2B-2D, which is relevant to synaptic signaling and potentially to drugs like ketamine. The study focuses on how this receptor opens, closes, and gets blocked, and it describes a new inhibition mechanism involving mechanical decoupling between specific subunit linkers. Source link [https://www.cell.com/neuron/fulltext/S0896-6273(25)00039-X] Reddit discussion [https://www.reddit.com/r/neuroscience/comments/1jwsxg5/structural_basis_for_channel_gating_and_blockade/] That's it for today.
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