Why Isn't Modafinil Used More for ADHD?

How SSRIs Actually Rewire Your Brain (and What Happens When You Stop)

Antidepressants like SSRIs and Strattera don't just fix a "chemical imbalance" — they trigger a months-long process of structural brain remodeling, from new dendritic spines to adult neurogenesis. This episode breaks down the molecular cascade from serotonin to BDNF to new neural growth, the three major brain networks that physically change during treatment, and the uncomfortable asymmetry: it takes weeks to build new connections but only days for them to retract after withdrawal. We explore what that means for relapse rates, informed consent, and whether the positive changes can ever last.

Why Your Mental Health Labels Might Be Wrong

If you or someone you know has been diagnosed with depression plus anxiety plus ADHD, you're not an unusual case — you're the norm. In this episode, we explore why psychiatric comorbidity is so common and what it reveals about the limitations of our diagnostic system. We break down the neurotransmitter hypothesis, the Research Domain Criteria (RDoC) framework, and why the DSM's 300+ categories might be capturing surface patterns rather than biological reality. We also look ahead to DSM-6 and what a hybrid dimensional-categorical system could mean for personalized treatment. This is an essential listen for anyone who's ever wondered whether their diagnoses really describe what's going on in their brain.

Why Strattera Works (or Fails) Depending on Your Liver

Why does Strattera (atomoxetine) give some people crippling anxiety while others get life-changing focus? This episode unpacks the pharmacology, from its selective norepinephrine action in the prefrontal cortex to the critical role of the CYP2D6 liver enzyme. We compare it head-to-head with bupropion for the ADHD-depression-fatigue triad and explain why your genetics—not just your willpower—determine whether this drug is a miracle or a nightmare.

The 15 Million People Living in Overseas Territories

Most people assume dozens of countries still hold overseas dependencies, but the real number is barely a dozen — and the story of how those territories survived decolonization is stranger and darker than you'd expect. From British coaling stations to American naval bases built on depopulated islands, this episode traces the common thread running through every overseas territory on Earth. We break down who owns what, why those territories weren't granted independence, and how legal doctrines from the 1900s still shape the lives of 15 million people today.

Designing a 2020s Art Deco for Jerusalem

What would a 2020s equivalent of Art Deco look like — one that picks up classical proportion and ornament while integrating everything modernism got right? Architect Hannah asked exactly that, and this episode builds the answer from the ground up. We explore proportional systems derived from the golden ratio, the window-to-wall ratios that align Passivhaus standards with traditional facades, and how Jerusalem's 1918 stone ordinance offers a model for form-based codes. We also tackle the cost objection to ornament — and explain why CNC routers and digital fabrication have made it obsolete. If you're an architect who wants to design something beautiful, traditional, and genuinely contemporary, this is your starting point.