Listen, Learn, Adapt

120: Midlife Vitamin D and Future Brain Tau Deposition

28 min · 15. maj 2026
episode 120: Midlife Vitamin D and Future Brain Tau Deposition cover

Beskrivelse

This episode dissects a study that investigates whether vitamin D levels in early midlife are linked to early brain indicators of dementia. Researchers analyzed data from the Framingham Heart Study, tracking participants for over 16 years to compare their initial blood samples with later PET scans. Mulligan MD, Scott MR, Yang Q, Wang R, Ghosh S, Johnson KA, et al. Association of circulating vitamin D in midlife with increased tau-PET burden in dementia-free adults. Neurol Open Access. 2026;2:e000057. doi:10.1212/WN9.0000000000000057. Follow Dr. Anthony Novello, PT, DPT ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

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123 episoder

episode 121: Early Exercise vs. Immobilization After Rotator Cuff Repair: A Meta-Analysis cover

121: Early Exercise vs. Immobilization After Rotator Cuff Repair: A Meta-Analysis

This episode dissects a meta-analysis and systematic review that examines the clinical impact of early exercise versus brace immobilization for patients recovering from arthroscopic rotator cuff repair. Hao BR, Li HQ, Liang A. Effects of early exercise and immobilization after arthroscopic rotator cuff repair surgery: a systematic review and meta-analysis of randomized controlled trials. BMC Musculoskelet Disord. 2025;26:254. doi:10.1186/s12891-025-08500-7,. Follow Dr. Anthony Novello, PT, DPT ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

18. maj 202637 min
episode 120: Midlife Vitamin D and Future Brain Tau Deposition cover

120: Midlife Vitamin D and Future Brain Tau Deposition

This episode dissects a study that investigates whether vitamin D levels in early midlife are linked to early brain indicators of dementia. Researchers analyzed data from the Framingham Heart Study, tracking participants for over 16 years to compare their initial blood samples with later PET scans. Mulligan MD, Scott MR, Yang Q, Wang R, Ghosh S, Johnson KA, et al. Association of circulating vitamin D in midlife with increased tau-PET burden in dementia-free adults. Neurol Open Access. 2026;2:e000057. doi:10.1212/WN9.0000000000000057. Follow Dr. Anthony Novello, PT, DPT ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

15. maj 202628 min
episode 119: Multidisciplinary Approaches and Exercise for Chronic Low Back Pain Management cover

119: Multidisciplinary Approaches and Exercise for Chronic Low Back Pain Management

This episode does a deep dive into a systematic review and meta-analysis evaluating the impact of multidisciplinary interventions that incorporate exercise to treat non-specific chronic low back pain. By analyzing 31 studies published between 1998 and 2021, the authors sought to determine if combined therapies effectively improve health outcomes across various global regions. Vega-Retuerta N, Sánchez-Parente S, Segura-Jiménez V. Effectiveness of multidisciplinary approaches including exercise to treat non-specific chronic low back pain: A systematic review and meta-analysis across multiple regions. Prev Med. 2025;199:108381. doi:10.1016/j.ypmed.2025.108381 Follow Dr. Anthony Novello, PT, DPT ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠ [https://www.instagram.com/anthonynovello.dpt/]

13. maj 202637 min