Rotations 2.0 Episode 68.1 Fungal Skin Infections

Rotations 2.0 Episode 68.1 Fungal Skin Infections

Send us Fan Mail [https://www.buzzsprout.com/2428578/fan_mail/new] Episode 68.1 Fungal Skin Infections Shoot me any comments or questions @Rotation2ptoh  on X  Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Motivational by Alex Grohl  Courtesy of Pixabay under Creative Commons non-commercial use.  Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Answers for Episode 68 Impetigo and Staph Scalded Skin Syndrome Question 1 A 3 year old child presents with fever, irritability, and widespread tender erythematous patches that rapidly evolve into fragile bullae. Gentle lateral pressure on the skin causes the superficial epidermis to shear off. Cultures taken from the bullae show no bacterial growth. Which of the following best explains the pathophysiology of this child’s condition? D. Hematogenous spread of exfoliative toxins targeting desmoglein 1 Question 2 A newborn develops flaccid bullae in well demarcated clusters on the trunk and diaper area. The bullae rupture easily, leaving behind a narrow rim of scale and thin brown crust. Bacterial cultures of the lesional fluid grow Staphylococcus aureus. Which of the following additional findings would most help distinguish this condition from staphylococcal scalded skin syndrome? C. Presence of viable bacteria within the bullae Question 3  A hospitalized adult with severe renal disease presents with widespread blistering, fever, and erythema. Blood cultures grow Staphylococcus aureus. The care team initiates IV oxacillin, but the patient fails to improve. Local antibiograms show high regional MRSA prevalence. According to current evidence summarized in the article, which of the following is the most appropriate next step in management? D. Switch to IV vancomycin Caraviello, Camila, Gianluca Nazzaro, Gianluca Tavoletti, Francesca Boggio, Nerina Denaro, Giulia Murgia, Emanuela Passoni, Valentina Benzecry Mancin, and Angelo Valerio Marzano. “Melanoma Skin Cancer: A Comprehensive Review of Current Knowledge.” Cancers17, no. 17 (2025): 2920.  Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

Rotations 2.0 Episode 68 Impetigo and Staph Scalded Skin Syndrome

Send us Fan Mail [https://www.buzzsprout.com/2428578/fan_mail/new] Episode 68 Impetigo and Staph Scalded Skin Syndrome Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Got That Heat by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS  Answers for Episode 67 Urticaria Q1. Diagnosis — hairdresser with immediate wheals A 28‑year‑old hairdresser develops intensely pruritic wheals on her hands and forearms within minutes of mixing bleaching powder at work. Symptoms resolve within several hours after leaving the salon. She denies prior episodes of anaphylaxis. Which of the following is the most appropriate initial diagnostic test? B. Skin prick testing (SPT) with ammonium persulfate using appropriate positive/negative controls Q2.  A 36‑year‑old operating room nurse has IgE‑mediated contact urticaria to natural rubber latex confirmed by positive SPT. Despite attempts to substitute gloves, occasional exposures still occur, leading to immediate pruritic wheals on the hands and wrists. She has never required epinephrine. Which of the following is the best initial pharmacologic strategy to reduce symptoms when complete avoidance is not feasible? A. Begin a second‑generation H1‑antihistamine and titrate up to four times the licensed daily dose as needed Q3.  A 24‑year‑old woman applies a new facial moisturizer and experiences burning and erythema within 15 minutes, with occasional small wheals limited to the application area. Ingredient review reveals benzoic acid. Which feature most strongly supports a diagnosis of non‑immunologic contact urticaria (NI‑CoU) rather than I‑CoU? D. Reactions can occur on first exposure and are dose‑dependent Paper for Next Week: Chanyachailert, Pattriya, Charussri Leeyaphan, and Sumanas Bunyaratavej. “Cutaneous Fungal Infections Caused by Dermatophytes and Non‑Dermatophytes: An Updated Comprehensive Review of Epidemiology, Clinical Presentations, and Diagnostic Testing.” Journal of Fungi 9, no. 6 (2023): 669. Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

Rotations 2.0 Episode 67 Urticaria

Send us Fan Mail [https://www.buzzsprout.com/2428578/fan_mail/new] Episode 67 Urticaria Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Pure Energy by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Answers for Episode 66  Contact Dermatitis Question 1 A 34‑year‑old hairdresser reports intensely pruritic, erythematous, and edematous lesions with vesiculation at the dorsal hands that begin within a few hours after she contacts a known workplace chemical at sites previously affected in the past. Which immunologic mechanism best explains the rapid onset of her local reaction? C. Activation of epidermal CD8+ tissue‑resident memory (TRM) cells that rapidly produce IFN‑γ and IL‑17 and drive neutrophil recruitment.  Question 2 Which of the following experimental findings would most directly support a pathogenic role for neutrophils in rapid‑onset allergic contact dermatitis in a mouse model? A.    Depletion of neutrophils prior to allergen challenge markedly reduces the early (<24 h) skin swelling and histologic neutrophil infiltrate.  Question 3 A researcher proposes a clinical trial to prevent rapid‑onset ACD flares by blocking neutrophil chemotaxis. Which therapeutic target discussed in the article is most appropriate for this strategy, and what practical limitation did the authors highlight for its use in real‑world rapid flares? A. Target CXCR2 to inhibit neutrophil recruitment; limitation — need for near‑immediate administration after allergen re‑exposure to prevent extravasation.  Paper for Next Week: Brazel, Morgan, Anand Desai, Abhirup Are, and Kiran Motaparthi. “Staphylococcal Scalded Skin Syndrome and Bullous Impetigo.” Medicina 57, no. 11 (2021): 1157. Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

Rotations 2.0 Episode 66 Contact Dermatitis

Send us Fan Mail [https://www.buzzsprout.com/2428578/fan_mail/new] Episode 66 Contact Dermatitis Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Sport Rock by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Answers for Episode 65  Eczema (Atopic Dermatitis) Question 1 — Systemic Therapy Selection A 32‑year‑old woman with moderate‑to‑severe atopic eczema has failed optimized topical corticosteroids, topical calcineurin inhibitors, and UVB therapy. She has no significant medical history and is not pregnant. She asks about the most evidence‑supported systemic therapy with the best long‑term safety profile and minimal laboratory monitoring. Which of the following is the most appropriate next‑line therapy? C. Dupilumab 600 mg loading dose, then 300 mg every 2 weeks Question 2 — Pediatric Treatment Decision A 10‑year‑old boy (weight 28 kg) has severe atopic eczema poorly controlled with optimized topical therapy and narrow‑band UVB. His parents prefer a systemic option that is FDA/EMA‑approved for his age group and does not require routine blood monitoring. Which treatment is most appropriate? B. Dupilumab 300 mg every 4 weeks Question 3 — Contraindicated Therapy in Pregnancy A 29‑year‑old woman with severe atopic eczema presents for follow‑up. She tells you she is 8 weeks pregnant and her disease is worsening despite appropriate topical corticosteroids and emollient therapy. Which of the following systemic therapies is contraindicated during pregnancy? C. Upadacitinib Paper for Next Week: Bizjak, Mojca, Olivier Aerts, David Pesqué, Melba Muñoz, Riccardo Asero, Margarida Gonçalo, Thomas Rustemeyer, Mitja Košnik, Mark Kačar, An Goossens, Jose Hernán Alfonso, Charlotte G. Mortz, Maryam Ali Al‑Nesf, Joachim W. Fluhr, Howard I. Maibach, and Ana Maria Giménez‑Arnau. “Contact Urticaria and Related Conditions: Clinical Review.” Contact Dermatitis 93 (2025): 87–107.   Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

Rotations 2.0 point Episode 65.1 Ibogaine and Executive Orders

Send us Fan Mail [https://www.buzzsprout.com/2428578/fan_mail/new] Episode 65.1  Ibogaine and Executive Order  Shoot me any comments or questions @Rotations2ptoh  on X Intro/Outro: Night Detective by Amaksi Courtesy of Pixabay under Creative Commons for non-Commercial Educational use only. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Papers referenced Mosca, Alessio, Stefania Chiappini, Andrea Miuli, Gianluca Mancusi, Maria Chiara Santovito, Francesco Di Carlo, Mauro Pettorruso, John M. Corkery, Carlos Canessa, Giovanni Martinotti, and Massimo Di Giannantonio. “Ibogaine/Noribogaine in the Treatment of Substance Use Disorders: A Systematic Review of the Current Literature.” Current Neuropharmacology 21, no. 11 (2023): 2178–2194.  Mackey, Katherine M., Johanna K. Anderson, Beth E. Williams, Rachel M. Ward, and Nicholas J. Parr. Evidence Brief: Psychedelic Medications for Mental Health and Substance Use Disorders. Washington, DC: Evidence Synthesis Program, Health Services Research and Development Service, Office of Research and Development, U.S. Department of Veterans Affairs, 2022. PRESIDENTIAL ACTIONS: ACCELERATING MEDICAL TREATMENTS FOR SERIOUS MENTAL ILLNESS Executive Orders April 18, 2026 Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.