LC/MS On-Line Training

This month we talk with Dr. Gary Schultz around his journey with LC-MS from graduate school to his days at Rohm and Haas to the world of high-sensitivity biomarker assays. Gary is a self-confessed LC-MS technology junkie but he has also consistently demonstrated an ability to see the practical solutions the advances in LC-MS instrumentation can achieve. He was an early adopter and advocate of nano-flow electrospray to agrochemical metabolite characterization. We discuss how this set the foundation for the development of the ESI Chip and its application for the quantification of protein biomarkers using nano-flow LC-MS. Gary also provides us his insights into where LC-MS technology and techniques may be heading with regard to new bioanalysis challenges. This podcast is a great listen for those interested in where LC-MS may be heading and to hear from someone who is highly regarded as an expert in his field. Don't forget to sign up for free Membership to gain access to the show notes on this podcast and many other advantages of the LC/MS Online Training community. The post #3 Gary Schultz: From Chemical Industry to Biomarkers and Beyond [https://lcms-online-training.com/podcast/lcmspodcasts/z-3-gary-schultz-chemical-industry-biomarkers-beyond/] appeared first on [https://lcms-online-training.com].

Description: Since his pioneering work at Cornell University with electrospray techniques, Dr. Jack Henion's name is synonymous with countless advances in LC/MS. Over his own career he has been the teacher, supervisor, mentor and collaborator to many successful scientists. He also founded two very successful LC/MS focused businesses, a bioanalysis CRO and a LC/MS product company. Still today Jack enjoys active participation at the frontiers of mass spectrometry. In this podcast we hear Jack's story of where it all started at 3:00 AM in a Cornell laboratory, what that led to today and a multitude of lessons along the way. Take a listen and you'll also hear his thoughts on techniques we may have inadvertently left behind and how some of this may shape the future of LC/MS. Don't forget to sign up for free Membership to gain access to the show notes on this podcast and many other advantages of the LC/MS Online Training community. The post #2 Jack Henion : Still in Search of the Ideal LC/MS System [https://lcms-online-training.com/podcast/lcmspodcasts/z-2-jack-henion-still-search-ideal-lcms-system/] appeared first on [https://lcms-online-training.com].

Description: Crystal City VI (CCVI), adds to the series of workshops held jointly by the FDA and AAPS. These workshops have historically helped pave the way for regulatory guidelines in bioanalysis. Following Crystal City V and the reference to biomarkers in the FDA draft Guidance on Bioanalytical Method Validation (BMV), this recent workshop set out to discuss the unique challenges that biomarkers present to the bioanalyst. The two day workshop covered discussions around large and small molecule biomarkers using chromatographic LC/MS approaches and ligand binding assay (LBA) strategies. As well as the FDA and drug development industry representatives, the clinical chemistry laboratory community was invited to the discussion. As such some robust debates and discussions around case examples and practical scenarios of biomarker bioanalysis were had. In this podcast we hear Dr. Steve Lowes perspective on the key elements of the workshop and where we go from here. Take a listen to this 30 minute discussion between Steve and Dr. Jack Henion then take a look at further information on Steve’s blog article and join the conversation. The post #1 What We Heard and Discussed at Crystal City VI [https://lcms-online-training.com/podcast/lcmspodcasts/z-lcms-podcast-1/] appeared first on [https://lcms-online-training.com].