The Lupus Forum

Discussing Lupus: S1PR1-mediated modulation as a treatment target, and obinutuzumab results in SLE

24 min · 9. apr. 2026
episode Discussing Lupus: S1PR1-mediated modulation as a treatment target, and obinutuzumab results in SLE cover

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Professor Ed Vital and Professor Chris Edwards discuss two recent studies advancing the treatment landscape in SLE. This episode discusses S1PR1-mediated modulation of immune cell trafficking as a potential upstream therapeutic strategy in SLE, and the efficacy and safety of obinutuzumab when added to standard therapy in adults with active SLE. Through expert-led discussion, this podcast offers practical perspectives for clinicians looking to stay at the forefront of lupus care.

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episode Discussing Lupus: New Phase 2 evidence in SLE and lupus nephritis cover

Discussing Lupus: New Phase 2 evidence in SLE and lupus nephritis

Professor Victoria Werth and Professor Chi-Chiu Mok discuss two recent studies advancing the treatment landscape in SLE and lupus nephritis. This episode reviews findings from the Phase 2 TULIP-LN trial, highlighting how anifrolumab treatment leads to rapid reductions in urinary biomarkers of intrarenal inflammation in lupus nephritis, and discusses a single-arm Phase 2 trial evaluating daratumumab in SLE. Through expert-led discussion, this podcast offers practical perspectives for clinicians looking to stay at the forefront of lupus care. To explore the full papers and download accompanying slide decks, visit the Lupus Forum. Stay up to date with the latest research and monthly podcast episodes through this free independent resource: https://lupus-forum.com/

18. mar. 202613 min