Biological Superintelligence: How Thomas Clozel Built Owkin into a $1B AI Drug Discovery Unicorn

Inside the $100M Venture Studio Reshaping Healthcare AI with John Beadle, Managing Director of Aegis Ventures

This episode dives into how venture studios are transforming healthcare innovation, with John Beadle sharing how Aegis Ventures leverages partnerships, industry relationships, and a flexible playbook to create impactful health tech companies. Whether you're an entrepreneur, investor, or healthcare leader, discover the strategies shaping the next wave of healthcare solutions.In this episode:The rationale behind founding a healthcare-focused venture studio versus traditional venture capital How Aegis built a strong partnership with Northwell Health and expanded with multiple systems The process of identifying and co-developing startups from scratch and the importance of trust The role of industry relationships and reputation in recruiting top-tier talent Differentiating between features, tools, and full company opportunities in health tech The significance of regulatory moats and data-driven branding as competitive advantages How health systems can evaluate startups for ROI and meaningful impact The potential for AI to address clinical challenges beyond administrative costs Building portfolio companies to coexist with giants like Epic and mitigate competitive risks Future trends in healthcare IPOs, private companies, and the evolving market landscape Timestamps:00:07 - Why venture studios are a game-changer in healthcare innovation02:40 - The evolution of Northwell partnership to a broad health system network04:13 - How Aegis co-develops startups from zero with health system insights15:53 - Recruiting top health tech talent using the Aegis brand and networks17:21 - Features versus full-scale companies in health tech problem sets19:46 - The importance of regulatory pathways and biomarkers in healthcare startups23:33 - How health systems and startups can collaborate for proven ROI44:14 - The increasing impact of AI in clinical decision-making and workflow53:06 - Coexisting with Epic and large incumbents in healthcare tech55:31 - Trends in public listings and private acquisitions for digital health firms56:44 - Rapid fire: Markets with high potential and underestimated moats57:22 - Changing perceptions: The critical role of trust in scaling healthcare solutions57:41 - Advice ignored: Launching Aegis despite the challengesMore on SathvikLinkedIn: www.linkedin.com/in/sathvik-bilakanti-8b5344169Care Shift: https://careshift.vc/Vaelion Ventures: https://www.vaelion.vc/More on John & Aegis VenturesJohn's LinkedIn: https://www.linkedin.com/in/johnpbeadle/Aegis Ventures Website: https://aegisventures.com/Aegis Ventures LinkedIn: https://www.linkedin.com/company/aegisventures/posts/?feedView=allAegis's approach exemplifies how carefully curated partnerships, industry trust, and a robust portfolio playbook allow healthcare venture studios to scale impactful innovations faster and more efficiently. As AI matures, the emphasis on regulatory moats and proven outcomes will be essential for startups aiming to differentiate in a crowded market.

The Future of Employer Health Insurance with Ty Wang, Co-Founder of Angle Health

Learn about the integration of AI in creating real-time, custom health plans and how Angle Health is revolutionizing patient care. Explore the challenges and opportunities in healthcare data, the role of AI in enhancing medical insights, and the importance of strategic partnerships in driving innovation. Main Insights: AI's Transformative Power: AI is revolutionizing healthcare by improving data integration and patient care.Investment in Innovation: Angle Health leverages high-quality data to drive breakthroughs in medical research. Strategic Integration: Successful AI integration requires collaboration with healthcare providers and embedding technology into existing workflows. Global Perspectives: The interconnected nature of global healthcare offers valuable lessons in innovation and data sharing. Challenges and Opportunities: Navigating data privacy, regulatory, and societal acceptance issues remains crucial for AI's Timestamps 00:00 Introduction to Angle Health and Market Positioning 03:35 Competitive Advantages of Angle Health 05:51 Innovative Quoting and Implementation Process 08:43 Sales Cycle and Broker Relationships 11:12 Building a Full Stack Health Plan 13:43 Adopting AI and Modern Technology 16:24 Personal Motivations Behind Angle Health 18:59 Navigating Challenges During COVID-19 21:22 Employee Trust and Company Culture 23:52 Management Style and Team Dynamics 26:04 Differentiation in the Health Plan Market 28:43 Unit Economics and Scaling Challenges 31:41 Operational Efficiency and Unit Economics 33:47 Building a Regulated Company 35:27 Sales Strategies for Health Plans 37:28 Broker Relationships and Value Proposition 39:29 AI Integration in Healthcare 41:38 Medicare's Influence on Commercial Plans 43:55 Cost Pressures and Market Opportunities 46:59 Member Experience and Advocacy 49:32 Future Vision for Angle Health 51:39 Go-to-Market Strategy Evolution More on Sathvik LinkedIn: www.linkedin.com/in/sathvik-bilakanti-8b5344169 Care Shift: https://careshift.vc/ Vaelion Ventures: https://www.vaelion.vc/ More on Ty and Angle Health Ty's LinkedIn: https://www.linkedin.com/in/tyw/ Angle Health Website: https://www.anglehealth.com/ Angle Health LinkedIn: https://www.linkedin.com/company/anglehealth/

150M Patients, $16M Raised: How SEQSTER Is Fixing Healthcare's Data Problem with Ardy Arianpour

Discover how AI is reshaping healthcare with Ardy Arianpour, founder and CEO of SEQSTER. Learn about the integration of AI in patient-centric interoperability, transforming fragmented health records into a unified platform. Explore the challenges and opportunities in healthcare data, the role of AI in enhancing medical insights, and the importance of strategic partnerships in driving innovation. Main Insights: AI's Transformative Power: AI is revolutionizing healthcare by improving data integration and patient care. Investment in Innovation: SEQSTER leverages high-quality data to drive breakthroughs in medical research. Strategic Integration: Successful AI integration requires collaboration with healthcare providers and embedding technology into existing workflows .Global Perspectives: The interconnected nature of global healthcare offers valuable lessons in innovation and data sharing. Challenges and Opportunities: Navigating data privacy, regulatory, and societal acceptance issues remains crucial for AI's integration. Timestamps 00:00 The Rise of Patient-Centric Interoperability 03:02 SEQSTER's Role in Healthcare Data 05:30 Navigating B2B Challenges in Healthcare 08:28 The Impact of AI on Healthcare Solutions 11:05 Surviving and Thriving in the Startup World 13:51 The Future of B2C in Healthcare 16:27 Understanding Metrics and Growth 19:14 The Ongoing Challenge of Data Fragmentation 21:54 Building Trust and Delivering Value 24:16 The Evolution of Seekster's Business Model 31:58 Interoperability Challenges in Healthcare 34:45 Navigating the Healthcare Startup Landscape 36:46 Data Harmonization and AI Integration 42:06 Compliance and Regulatory Considerations 47:23 Transforming Clinical Trials with AI 50:05 Advice for Founders in Data Interoperability 53:40 The Future of Healthcare and Personal Motivation More on Sathvik LinkedIn: www.linkedin.com/in/sathvik-bilakanti-8b5344169 Care Shift: https://careshift.vc/ Vaelion Ventures: https://www.vaelion.vc/ More on Ardy & SEQSTER Ardy's LinkedIn: https://www.linkedin.com/in/ardyarianpour/ SEQSTER LinkedIn: https://www.linkedin.com/company/seqster/ SEQSTER Website: https://seqster.com/

Stop Making Vague ROI Claims. What Cityblock's President Says Actually Wins In Healthcare Deals

Most startups kill their growth by not understanding what really convinces payers, but our guest, Mike Roaldi, has cracked the code. After a decade at UnitedHealth, where he mastered the art of winning enterprise deals, he’s now leading CityBlock’s revolutionary expansion into Medicaid and Medicare at a scale most founders only dream of. This episode reveals the insider secrets to building credibility, demonstrating impact, and sealing those critical partnerships, all rooted in Mike’s deep experience navigating complex health systems.You’ll discover how top health organizations evaluate startups: Why concrete, granular ROI metrics beat vague promises every time. Mike shares the counterintuitive truth about storytelling in pitches: We also dive into the mechanics of navigating multi-layered organizational decisions: Why patience, responsiveness, and organizational cohesion often seal the deal faster than a perfect slide deck. Plus, Mike reveals his approach to transparent performance data, why that builds trust faster, and how AI is embedded everywhere in CityBlock’s model—from risk profiling to direct member engagement.Why does understanding provider diversity and the social determinants of health matter more than ever? Mike’s firsthand stories shed light on designing connected, community-centric care that’s scalable without losing the local touch. And for founders wondering about the long game, he discusses key strategic choices, like hiring industry insiders versus technical geniuses, that can make or break your healthcare venture at scale.This episode is perfect for health entrepreneurs, product teams, and anyone eager to turn initial pilots into sustainable, insurable growth. More on SathvikLinkedIn: www.linkedin.com/in/sathvik-bilakanti-8b5344169X:x.com/sathvikbilCare Shift: https://careshift.vc/Vaelion Ventures: vaelion.vcMore on MikeLinkedIn: https://www.linkedin.com/in/michaelbroaldi/Cityblock Health Website: https://www.cityblock.com/

Biological Superintelligence: How Thomas Clozel Built Owkin into a $1B AI Drug Discovery Unicorn

Explore the transformative role of AI in biotech with Thomas Clozel, co-founder of Owkin. Discover how AI is reshaping drug discovery, personalized medicine, and the future landscape of healthcare.Founded in 2016 by Thomas (a former clinical hematologist) and AI researcher Gilles Wainrib, Owkin pioneered federated learning in healthcare, a technique that lets AI models learn from siloed hospital and biopharma datasets without ever moving the underlying patient data. The result: a platform that turns the world's most sensitive medical data into one of its most powerful research engines.Owkin became a unicorn in November 2021 after a $180M strategic investment from Sanofi, and has raised ~$300M+ in total from investors including Google Ventures, Bpifrance, F-Prime Capital, Eight Roads, and Mubadala. The company partners with leading pharma companies (Sanofi, BMS, Amgen, Roche) and top medical institutions (Mount Sinai, Institut Curie, Léon Bérard) to accelerate drug discovery, optimize clinical trials, and advance precision oncology.Main Insights: AI's Transformative Power: AI is revolutionizing biotech by enhancing the understanding of complex diseases and accelerating drug development.Investment in Innovation: Owkin focuses on leveraging high-quality data and federated learning to drive breakthroughs in medical research.Strategic Integration: Successful AI integration requires collaboration with hospitals and embedding technology into existing workflows.Global Perspectives: The interconnected nature of global healthcare offers valuable lessons in innovation and data sharing.Challenges and Opportunities: Navigating data privacy, regulatory, and societal acceptance issues remains crucial for AI's integration.More on SathvikLinkedIn: www.linkedin.com/in/sathvik-bilakanti-8b5344169X:x.com/sathvikbilCare Shift: https://careshift.vc/Vaelion Ventures: vaelion.vcMore on Thomas Clozel & OwkinLinkedIn: https://www.linkedin.com/in/thomas-clozel-408a9321/X: https://x.com/TClozelOwkin: https://www.owkin.com/