The Human and Economic Toll of Treatment-Resistant Depression

Patient's Rising's Terry Wilcos: The gap between FDA approval and patient access for Alzheimer's treatments

Terry Wilcox, Co-founder and CEO of Patients Rising, discusses the critical gap between FDA approval and patient access for new early-onset Alzheimer's treatments. She shares personal insights from her experience as a caregiver and explains how the ASAP Act aims to fix the policy hurdles preventing families from accessing life-changing innovation.

American Commitment's Phil Kerpen: The Hidden Drivers of Hospital Consolidation

Phil Kerpen, President of American Commitment, joins the show to discuss why hospitals often escape public blame for rising healthcare costs despite vertical price increases. He explains how tax-exempt status, "facility fees," and the consolidation of independent physician groups have eroded competition. The conversation also explores the massive lobbying power of health systems and how federal regulations like the medical loss ratio inadvertently incentivize higher spending.

Dr. Jeremy Levin: Why Biotech Is Not Big Pharma

Dr. Jeremy Levin, author of 'Biotech in the Balance,' explains why small biotech firms—not Big Pharma—are the true engines of medical discovery. He discusses the sector's unique capital risks and the growing public distrust that threatens the future of American innovation.

The $100 Billion Loophole: Why 340B Reform is Essential

Economist Wayne Winegarden joins the podcast to expose how the 340B Drug Discount Program evolved from a small safety net for rural clinics into a \$100 billion revenue engine for massive hospital systems. He explores how misaligned incentives drive up drug spending, fuel hospital consolidation, and why transparency is the first step toward reform.

The Human and Economic Toll of Treatment-Resistant Depression

Treatment-resistant depression (TRD) affects millions of Americans and carries significant personal, clinical, and economic consequences. In this episode of the Health Policy Podcast, host Bryan Hyde speaks with Dr. William Sauvé, Chief Medical Officer of Osmind, and Mark Desmarais, Principal at Health Management Associates, about new research examining the impact of TRD on patients and the healthcare system. Drawing on a comprehensive analysis of Medicare claims data, Desmarais explains how patients with TRD generate approximately $8,000 more in annual healthcare costs than patients whose depression is effectively managed. The discussion explores the reasons behind these costs, including higher rates of physician visits and hospitalizations, as well as their impact on both individuals and caregivers. Dr. Sauvé, a psychiatrist with extensive experience treating complex depression cases in both military and civilian settings, discusses TRD, the challenges patients face after multiple unsuccessful medication trials, and the importance of identifying effective treatments. The conversation also examines workforce shortages in mental health care, barriers posed by prior authorization requirements, and how delaying effective treatment can worsen patient outcomes and increase healthcare spending.