The Pharma Closeout | Daily Pharmaceutical & Biotech News in 15 Minutes

Daily Roundup | GSK Wins First Lung Cancer Approval — Jideytro Validates a $10.6B Bet

GSK's Jideytro cleared the FDA two months early — a week after the $10.6B Nuvalent deal closed — for GSK's first lung cancer approval. Plus Arrowhead's plozasiran (Redemplo) posts best-case triglyceride and pancreatitis data against Ionis's Tryngolza, Summit's ivonescimab two-year NSCLC survival ahead of its November decision, Celldex's Phase 2 failure in prurigo nodularis, Sanofi's FDA untitled letter over Beyfortus and Pfizer's RSV vaccine, and Trump's 200% generic tariff countdown. Visit us at thepharmacloseout.com.

Daily Roundup | Novo Sues Lilly Over GLP-1 Ads: The Dose-Comparison Fight That Could Rewrite Obesity Marketing

Novo Nordisk sued Eli Lilly in federal court over "deceptive" ads comparing high-dose Zepbound and Mounjaro to lower-dose Wegovy and Ozempic. Also: Gilead and Merck back the first weekly oral HIV pill (islatravir/lenacapavir) with 48-week Phase 3 data, Novartis beats Q2 on Kisqali and Pluvicto as pelacarsen looms, Agios scraps sickle cell drug tebapivat, Dimension closes an $800M AI-biotech fund, Bristol Myers builds an NVIDIA AI supercomputer, and Amgen settles a $74M investor suit. Visit us at thepharmacloseout.com.

Daily Roundup | Tempus AI Buys Personalis for $1.5B in MRD Cancer Push

Tempus AI is buying Personalis for $1.5 billion, betting on cancer monitoring before reimbursement catches up. Plus Samsung Biologics' $1.8B all-cash bid for Swiss peptide maker PolyPeptide and its GLP-1 push, Legend Biotech's record Carvykti sales against a falling stock, Jennifer Doudna's Scribe Therapeutics CRISPR IPO, GSK shelving a $2B cough drug, Bristol Myers Squibb's Nvidia AI supercomputer, Takeda's dengue vaccine nod in India, and Novartis Fabhalta in IgA nephropathy. Visit us at thepharmacloseout.com.

Week in Review | GSK Kills Camlipixant: The P2X3 Cough Bet Just Went to Zero

GSK wrote off most of a $2 billion bet as camlipixantbecomes the third P2X3 antagonist to fail in chronic cough. Plus Lilly's $2.8B AtaiBeckley deal and July's IPO wave, Novartis Fabhalta's full approval in IgAN, Celcuity's Revtorpyk, Merck's oral PCSK9 pill and sac-TMT lung-cancerdata, the Jasper–Kira merger, and the Sanofi Sarclisa FDA decision ahead. Visit us at thepharmacloseout.com.

Daily Roundup | GSK Kills Camlipixant: The $2B Bellus Bet Unravels

GSK shelved camlipixant after mixed Phase 3 data — the third P2X3 chronic cough drug to fail and a blow to its ~$2B Bellus Health deal. Plus Jasper Therapeutics' lifeline merger with Kira and a $132M raise, Novartis Fabhalta's full FDA approval in IgA nephropathy, Lilly's $2.8B AtaiBeckley psychedelics buyout, a Merck ADC lung cancer readout, and a Pfizer downgrade. Visit us at thepharmacloseout.com.