Antibodies! Ep. 2: Fc Engineering & Bispecifics with John Desjarlais

Antibodies! Ep. 2: Fc Engineering & Bispecifics with John Desjarlais

We’re excited to share episode 2 of the Antibodies! podcast, recorded live at the Antibody Engineering & Therapeutics conference in San Diego. Host ⁠Dr. Jonathan Davis⁠ [https://www.linkedin.com/in/jonathandavis-bispecifics/] PhD (Founder, Creative Antibodies) sits down with ⁠John Desjarlais⁠ [https://www.linkedin.com/in/johndesjarlais/] PhD, Chief Scientific Officer at Xencor, to discuss learnings from two decades of antibody engineering: Fc platforms, T-cell engagers in solid tumors, and bispecifics in autoimmune disease. In this conversation, they discuss: * How a classical trombonist ended up engineering some of the most widely used Fc platforms in antibody therapeutics * The KLH study that proved obexelimab could shut down B cells. Data so meaningful, John still keeps the plot on his office wall * Why target selectivity matters more than immune environment for T-cell engagers in solid tumors * The autoimmune gold rush: using T-cell engaging bispecifics to reset the immune system, inspired by Georg Schett’s CAR-T breakthrough * Trispecifics, AND-gate targeting, and where bispecifics can go beyond oncology Be sure to listen all the way to the end for a surprise treat - an improvised harmonica blues duet between Jonathan and John! If you missed our previous episodes, you can find them here: ⁠https://tabs-antibodiespodcast.podbean.com/⁠ [https://tabs-antibodiespodcast.podbean.com/]

Antibodies! Ep. 1: The Antibody Frontier with Dr. Janine Schuurman

Antibodies! Ep. 1: The Antibody Frontier with Dr. Janine Schuurman For our debut episode, host ⁠Dr. Jonathan Davis⁠ [https://www.linkedin.com/in/jonathandavis-bispecifics/] (Founder, Creative Antibodies) sits down with ⁠Dr. Janine Schuurman⁠ [https://nl.linkedin.com/in/janine-schuurman-8105a35] (Board member and current President of The Antibody Society & Founder, Lust for Life Science B.V., formerly SVP Antibody Research & Technology of Genmab) to discuss collaboration, curiosity, and the future of antibody therapeutics. In this conversation, they reflect on their professional journeys and discuss: * The mission of The Antibody Society. * The power of community and collaboration. * How unexpected results can lead to meaningful discoveries. * The joy and importance of creativity, curiosity, and experimentation. * How camaraderie sustains the antibody scientific community. We sincerely hope you will enjoy this episode and stay with us for more conversations to come! If you missed our previous episodes, you can find them here: ⁠https://tabs-antibodiespodcast.podbean.com/⁠ [https://tabs-antibodiespodcast.podbean.com/]