Ketamine & Cocaine: Ranking Drugs for Longevity (Part 1)

Psilocybin, LSD & Marijuana: Ranking Drugs for Longevity (Part 2)

Should I try shrooms for science? In part two of three of our series investigating drugs for longevity, I’m putting psilocybin, LSD and DMT under the microscope - and revealing some pretty exciting research that connects psychedelics to longer lifespans. We’ll also talk about weed, and what the data says about marijuana for longevity.   Study Links: Psilocybin for Cancer Patients [https://pmc.ncbi.nlm.nih.gov/articles/PMC5367557/]   LSD: Longevity in Worms [https://www.biorxiv.org/content/10.1101/2025.06.16.659936v1.full] Cannabis Use Disorder Increases Mortality Risk [https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2829914] Marijuana Increases Epigenetic Aging [https://link.springer.com/article/10.1186/s13148-022-01359-8] Marijuana’s Impacts on Sleep [https://pubmed.ncbi.nlm.nih.gov/24726015/]  Improving Sleep with Medical Cannabis [https://pubmed.ncbi.nlm.nih.gov/36539991/] Hosts: Bryan Johnson: Blueprint Founder Kate Tolo: Blueprint Co-Founder Dr. Mike Mallin: Lead Physician for Bryan Johnson Connect:  X: https://x.com/bryan_johnson [https://x.com/bryan_johnson] YouTube: https://www.youtube.com/@BryanJohnson [https://www.youtube.com/@BryanJohnson] Instagram:  https://www.instagram.com/bryanjohnson   [https://www.instagram.com/bryanjohnson] TikTok:  https://www.tiktok.com/@_bryan_johnson_ [https://www.tiktok.com/@_bryan_johnson_] Chapters:  00:00 - Introduction  01:52 - First Experiences With Drugs  05:42 - Psychedelics in Society  13:29 - Psilocybin, LSD & DMT  34:35 - Marijuana  50:53 - Longevity Rankings

Ketamine & Cocaine: Ranking Drugs for Longevity (Part 1)

Can doing lines help you live longer? That depends on what you’re taking. In this three-part series, I’m ranking drugs based on their ties to longevity, starting with ketamine and cocaine. I tested ketamine on myself to study its impacts on the brain — here’s what we found.   Study Links: Ketamine’s Effects on Epigenetic Age  [https://www.medrxiv.org/content/10.1101/2024.09.10.24313258v1.full?] Extending Ketamine’s Therapeutic Window [https://www.science.org/doi/10.1126/science.abb6748] Ibogaine Therapy for PTSD [https://www.nature.com/articles/s41591-023-02705-w]  Hosts: Bryan Johnson: Blueprint Founder Kate Tolo: Blueprint Co-Founder Dr. Mike Mallin: Lead Physician for Bryan Johnson Connect:  X: https://x.com/bryan_johnson [https://x.com/bryan_johnson] YouTube: https://www.youtube.com/@BryanJohnson [https://www.youtube.com/@BryanJohnson] Instagram:  https://www.instagram.com/bryanjohnson   [https://www.instagram.com/bryanjohnson] TikTok:  https://www.tiktok.com/@_bryan_johnson_ [https://www.tiktok.com/@_bryan_johnson_] Chapters:  00:00 - Introduction  03:14 - Social Norms Around Drugs  08:59 - Psychedelics as Therapy: Overview  10:20 - Cocaine  17:15 - Fentanyl Dangers  23:27 - Ketamine: Brain Impacts + Longevity  41:29 - Measuring The Impacts of Psychedelics   47:51 - Longevity Rankings: Cocaine + Ketamine

Jesse James West on AI, Fitness & Self-Worth

Fitness creator Jesse James West is a natural bodybuilder who makes some of the coolest videos on YouTube for over 7 million subscribers. We’re talking about his motto of “stay relentless,” and how he balances work, health and life now that he’s newly married. Plus, he shares about the time that he also had a breakdown in Target - and how it may have saved his life. Connect with Bryan:  X: https://x.com/bryan_johnson [https://x.com/bryan_johnson] YouTube: https://www.youtube.com/@BryanJohnson [https://www.youtube.com/@BryanJohnson] Instagram:  https://www.instagram.com/bryanjohnson   [https://www.instagram.com/bryanjohnson] TikTok:  https://www.tiktok.com/@_bryan_johnson_ [https://www.tiktok.com/@_bryan_johnson_] Connect with Jesse:  YouTube: https://www.youtube.com/@JesseJamesWest [https://www.youtube.com/@JesseJamesWest] Instagram: https://www.instagram.com/jessejameswest [https://www.instagram.com/jessejameswest/?hl=en] TikTok: https://www.tiktok.com/@jessejameswest [https://www.tiktok.com/@jessejameswest] X: https://x.com/jessejameswestt [https://x.com/jessejameswestt?lang=en] Chapters:  00:00:00 - Introduction  00:01:15 - Finding Work Life Balance 00:08:32 - Stay Relentless  00:11:01 - Jesse’s Darkest Moment + What He Learned   00:22:48 - What an AI Future Looks Like  00:27:24 - Jesse’s Health Protocol  00:34:26 - Longevity, Psychedelics, & Aliens  00:44:58 - Married Life + Family Planning  00:48:55 - Top Tips for Longevity  00:54:02 - Bodybuilding, Steroids, & Healthy Eating  00:57:23 - Jet Lag Protocol  00:59:32 - Living For Tomorrow = Living Forever  01:02:45 - Jesse’s Health Goals

Don’t ‘Dye’ - Empowering Kids to Understand Health

Between synthetic dyes, air pollution, and environmental toxins, kids have a lot of obstacles in the way of their health. I’m reviewing some top offenders (like synthetic dyes and added sugars) and discussing how to empower our kids to make informed choices.  Study Links:  Synthetic Dyes in Food & Beverages [https://www.jandonline.org/article/S2212-2672(25)00166-2/fulltext] HEPA Filters in LA Schools [https://jhr.uwpress.org/content/early/2023/02/01/jhr.0421-11642R2] US Kids Face Deadlier Odds [https://pubmed.ncbi.nlm.nih.gov/40622733/] Peanut Allergies & Air Pollution [https://pubmed.ncbi.nlm.nih.gov/39453339/] Hosts: Bryan Johnson: Blueprint Founder Kate Tolo: Blueprint Co-Founder Dr. Mike Mallin: Lead Physician for Bryan Johnson Connect:  X: https://x.com/bryan_johnson [https://x.com/bryan_johnson] YouTube: https://www.youtube.com/@BryanJohnson [https://www.youtube.com/@BryanJohnson] Instagram:  https://www.instagram.com/bryanjohnson   [https://www.instagram.com/bryanjohnson] TikTok:  https://www.tiktok.com/@_bryan_johnson_ [https://www.tiktok.com/@_bryan_johnson_] Chapters:  00:00 - Introduction  02:20 - Synthetic Dyes + Added Sugars   14:20 - Teaching Kids About Nutrition  20:21 - Toxins, Food Allergies, & Air Quality  22:42 - Kids Health Protocol  24:24 - Screen Time, Social Media & Mental Health  26:22 - U.S. Kids Are Dying at Higher Rates 29:44 - Societal Changes for Better Health 34:41 - Empowering Kids to Make Healthy Choices

Nobody Taught You THIS About Sex

My team and I looked into the biological effects of eating a*s and choking during sex - here’s what we found. I’m also sharing why I monitor my erections - and why this metric is critical for good health and longevity.  Study Links:  Choking During Sex  [https://pubmed.ncbi.nlm.nih.gov/40062485/] Overnight Erections [https://pubmed.ncbi.nlm.nih.gov/7990298/] Female Erection Cycles [https://jurolsurgery.org/articles/doi/jus.galenos.2023.2022.0051]  Hosts: Bryan Johnson: Blueprint Founder Kate Tolo: Blueprint Co-Founder Dr. Mike Mallin: Lead Physician for Bryan Johnson Connect:  X: https://x.com/bryan_johnson [https://x.com/bryan_johnson] YouTube: https://www.youtube.com/@BryanJohnson [https://www.youtube.com/@BryanJohnson] Instagram:  https://www.instagram.com/bryanjohnson   [https://www.instagram.com/bryanjohnson] TikTok:  https://www.tiktok.com/@_bryan_johnson_ [https://www.tiktok.com/@_bryan_johnson_] Chapters:  00:00 - Introduction  01:15 - Taboos Around Sex  04:50 - Sex is Good For You  08:33 - Choking During Sex  15:06 - Anilingus (Rimming)  22:20 - Sexual Preferences + Microbiome  25:25 - Erection Cycles: Male and Female  34:38 - We Need More Conversations About Sex