C4E Presents
Ben Novak [http://linkedin.com/in/ben-novak-b3235023] is bringing back the extinct passenger pigeon. Host Heather Lynch and Novak, program manager for the Biotechnology for Bird Conservation Program for Revive & Restore [https://reviverestore.org/], discuss de-extinction, restoring ecosystem function by using gene editing or selective breeding to give living relatives traits needed to fill extinct species’ ecological roles, and correcting Jurassic Park misconceptions about using ancient DNA directly. Novak explains how museum specimens provide fragmented DNA for sequencing and the limits of mapping genomes, emphasizing goal-oriented trait recovery over perfect genetic identity. Learn more with: * “Could Extinct Species Save Today’s Forests? Scientist Makes the Case for Darwin Day [https://news.stonybrook.edu/university/could-extinct-species-save-todays-forests-scientist-makes-the-case-for-darwin-day/]” * “De-Extinction [https://www.mdpi.com/2073-4425/9/11/548]” by Ben Novak * “Towards Practical Conservation Cloning: Understanding the Dichotomy Between the Histories of Commercial and Conservation Cloning [https://www.mdpi.com/2076-2615/15/7/989?utm_source=researchgate.net&utm_medium=article]” by Ben J. Novak, Stewart Brand, Ryan Phelan, Sasha Plichta, Oliver A. Ryder and Robert J. Wiese * “First endangered black-footed ferrets, Mustela nigripes, cloned for genetic rescue [https://www.biorxiv.org/content/10.1101/2024.04.17.589896v1]” by Ben Novak, et al. * “Natural Selection Shaped the Rise and Fall of Passenger Pigeon Genomic Diversity [https://www.science.org/doi/10.1126/science.aao0960]” by Ben Novak, et al. Skip ahead to the chapter that interests you: * 01:40 Defining De-Extinction * 02:44 Jurassic Park Myths * 05:32 Where The DNA Comes From * 08:41 Sample Quality And Tissues * 11:44 Mapping Ancient Genomes * 14:16 How Close Is Close Enough * 23:04 Naming De-Extinct Species * 25:30 Tiny Mutations Big Traits * 28:12 Building Diversity In * 30:56 Passenger Pigeon Progress * 31:33 Ferret Genetic Rescue * 33:55 Why Birds Are Hard * 35:52 Germ Cell Workaround * 37:55 Mitochondria Purity Myth * 44:16 Policy And Release * 46:46 Stem Cells Future Tools Tell a friend and share a link to this episode. You can find all our episodes at www.stonybrook.edu/c4e [http://www.stonybrook.edu/c4e] or wherever you stream audio. Sign up for our newsletter: https://www.stonybrook.edu/commcms/c4e/newsletters.php [https://www.stonybrook.edu/commcms/c4e/newsletters.php] For all things Stony Brook on social media: https://gosbu.co/m/social C4E Presents is a production of Stony Brook’s Collaborative for the Earth. Host: Heather Lynch Editor: J.D. Allen Program Manager: Jennifer Gilday
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