Dr. Neil Iyengar & Dr. Ticiana Leal - ADC Integration in Breast & Lung Cancer: The Role of Dato-DXd

Dr. Megan Kruse & Dr. Lukas Delasos - ADC Integration & Toxicity in Breast and Thoracic Oncology

As the ADC landscape expands, how is datopotamab deruxtecan redefining the treatment paradigm for both breast and lung cancer? In this episode of CHM Conversations, Dr. Megan Kruse and Dr. Lukas Delasos break down the clinical integration of next-generation ADCs. The discussion differentiates the roles of ADCs such as datopotamab deruxtecan and trastuzumab deruxtecan, examining their impact across HER2-directed and Trop-2 targeted settings in both metastatic breast cancer and thoracic oncology. Beyond the data, the clinicians share practical insights on navigating sequencing challenges, resistance mechanisms, and the evolving role of biomarkers in personalizing care. A major focus is placed on proactive toxicity management, highlighting essential protocols to ensure treatment continuity and optimize patient outcomes. A strategic resource for oncology clinicians navigating the future of ADC therapy, biomarker-guided treatment selection, and precision oncology across breast and lung cancer. 🎧 Watch more expert-led oncology conversations from CHM Conversations. #BreastCancer #LungCancer #NSCLC #ADC #AntibodyDrugConjugates #HER2Low #EGFR #DatopotamabDeruxtecan #TrastuzumabDeruxtecan #PrecisionOncology #TargetedTherapy #MedicalOncology #ThoracicOncology #BreastOncology #ILD #CommunityHealthMedia – Thanks for watching! Our podcasts are also available on: • Spotify - https://spotf.fi/chm-podcast • Amazon Music - https://amazn.so/chm-podcast • Apple Podcast - https://podcasts.apple.com/us/podcast/community-health-media/id1837428248 • Castbox - https://castbox.fm/vh/6735434 • Goodpods - https://goodpods.com/profile/chm-111066 • iHeartRadio - https://iheart.com/podcast/291542082 • Pocket Casts - https://pca.st/3ncdh11o – Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences. We’re an integrated marketing company that produces world-class content and curated peer to peer live experiences. We specialize in: • Peer to peer interviews, panels & round-tables • Curated live events & conferences • Professional in-depth content & research updates • Interactive learning modules & webinars • Live & on-demand webcasts & podcasts Learn more about us here - https://communityhealth.media

Dr. Rao & Dr. Nasrazadani – The Second-Line Landscape for HR+/HER2- mBC: The Role of Capivasertib

The second-line landscape for HR+/HER2- metastatic breast cancer is shifting rapidly with the detection of truncal mutations. In this episode of CHM Conversations, Dr. Ruta Rao and Dr. Azadeh Nasrazadani discuss how the detection of PIK3CA, AKT, and PTEN mutations is redefining the role of capivasertib. The clinicians differentiate the clinical application of capivasertib from other targeted agents like alpelisib and inavolisib, exploring how mechanistic differences and biomarker profiles influence patient selection. A central focus is placed on mastering the safety profile of these agents, providing practical strategies for managing stomatitis, diarrhea, and hyperglycemia to ensure treatment continuity and optimize patient outcomes. An essential resource for oncology teams navigating the complexities of the PI3K/AKT/PTEN pathway and optimizing supportive care in the second-line metastatic breast cancer landscape. 🎧 Watch more expert-led oncology conversations from CHM Conversations. #BreastCancer #HRPositive #MetastaticBreastCancer #PrecisionOncology #BiomarkerTesting #PIK3CA #ESR1 #Capivasertib #LiquidBiopsy #EndocrineTherapy #CommunityHealthMedia – Thanks for watching! Our podcasts are also available on: • Spotify - https://spotf.fi/chm-podcast • Amazon Music - https://amazn.so/chm-podcast • Apple Podcast - https://podcasts.apple.com/us/podcast/community-health-media/id1837428248 • Castbox - https://castbox.fm/vh/6735434 • Goodpods - https://goodpods.com/profile/chm-111066 • iHeartRadio - https://iheart.com/podcast/291542082 • Pocket Casts - https://pca.st/3ncdh11o – Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences. We’re an integrated marketing company that produces world-class content and curated peer to peer live experiences. We specialize in: • Peer to peer interviews, panels & round-tables • Curated live events & conferences • Professional in-depth content & research updates • Interactive learning modules & webinars • Live & on-demand webcasts & podcasts Learn more about us here - https://communityhealth.media

Dr. Hope Rugo & Dr. Rebecca Shatsky - Dato-DXd & First-Line ADC Strategies in Metastatic TNBC

How is Dato-DXd redefining first-line mTNBC? In this episode of CHM Conversations, Dr. Hope Rugo and Dr. Rebecca Shatsky discuss the TROPION-Breast02 trial results and how this data fits into the broader landscape alongside the ASCENT-03 findings. The clinicians focus on the shift toward frontline Trop2-directed strategies and how these agents are challenging the chemotherapy-only paradigm. They also address the practicalities of management—specifically managing stomatitis and ocular toxicity while navigating CNS disease and supportive care. An essential resource for oncology clinicians navigating the future of precision ADC therapy in triple-negative breast cancer. 🎧 Watch more expert-led oncology conversations from CHM Conversations. #TripleNegativeBreastCancer #TNBC #MetastaticBreastCancer #ADCtherapy #SacituzumabGovitecan #DatopotamabDeruxtecan #Trop2 #BreastOncology #MedicalOncology #PrecisionOncology #CommunityHealthMedia – Thanks for watching! Our podcasts are also available on: • Spotify - https://spotf.fi/chm-podcast • Amazon Music - https://amazn.so/chm-podcast • Apple Podcast - https://podcasts.apple.com/us/podcast/community-health-media/id1837428248 • Castbox - https://castbox.fm/vh/6735434 • Goodpods - https://goodpods.com/profile/chm-111066 • iHeartRadio - https://iheart.com/podcast/291542082 • Pocket Casts - https://pca.st/3ncdh11o – Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences. We’re an integrated marketing company that produces world-class content and curated peer to peer live experiences. We specialize in: • Peer to peer interviews, panels & round-tables • Curated live events & conferences • Professional in-depth content & research updates • Interactive learning modules & webinars • Live & on-demand webcasts & podcasts Learn more about us here - https://communityhealth.media

Dr. Hope Rugo & Dr. Rebecca Shatsky - Earlier ESR1 Detection & Oral SERDs in Metastatic Breast Cancer

Can earlier ESR1 mutation detection help delay progression and preserve quality of life? In this episode of CHM Conversations, Dr. Hope Rugo and Dr. Rebecca Shatsky discuss the evolving role of oral SERDs and ctDNA monitoring in HR+ mBC. The conversation centers on the SERENA-6 trial and the strategy of identifying ESR1 mutations before radiographic progression. Dr. Rugo and Dr. Shatsky explore how intervening earlier with camizestrant—while maintaining the CDK4/6 inhibitor backbone—may prolong progression-free survival and delay the transition to more intensive chemotherapy or ADCs. The clinicians examine how these mutations develop as acquired resistance and discuss the broader shift away from the traditional “wait for progression” approach. They also address the real-world logistics of precision medicine, including testing frequency, quantitative monitoring, and the potential to reduce the frequency of traditional scans. A valuable discussion for oncology clinicians navigating endocrine resistance and the future of biomarker-driven care in metastatic breast cancer. 🎧 Watch more expert-led oncology conversations from CHM Conversations. #BreastCancer #MetastaticBreastCancer #HRPositive #HER2Negative #ESR1 #OralSERD #Camizestrant #SERENA6 #ctDNA #LiquidBiopsy #PrecisionOncology #CDK46 #EndocrineTherapy #PIK3CA #TargetedTherapy #MedicalOncology #BreastOncology #CommunityHealthMedia – Thanks for watching! Our podcasts are also available on: • Spotify - https://spotf.fi/chm-podcast • Amazon Music - https://amazn.so/chm-podcast • Apple Podcast - https://podcasts.apple.com/us/podcast/community-health-media/id1837428248 • Castbox - https://castbox.fm/vh/6735434 • Goodpods - https://goodpods.com/profile/chm-111066 • iHeartRadio - https://iheart.com/podcast/291542082 • Pocket Casts - https://pca.st/3ncdh11o – Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences. We’re an integrated marketing company that produces world-class content and curated peer to peer live experiences. We specialize in: • Peer to peer interviews, panels & round-tables • Curated live events & conferences • Professional in-depth content & research updates • Interactive learning modules & webinars • Live & on-demand webcasts & podcasts Learn more about us here - https://communityhealth.media

Dr. Neil Iyengar & Dr. Ticiana Leal - ADC Integration in Breast & Lung Cancer: The Role of Dato-DXd

How are clinicians navigating the complex balance between immunotherapy and antibody-drug conjugates? In this episode of CHM Conversations, Dr. Neil Iyengar and Dr. Ticiana Leal discuss the integration of Dato-DXd into the rapidly evolving treatment paradigms for breast and lung cancer. The experts break down the practicalities of sequencing these therapies, moving beyond traditional chemotherapy to determine where ADCs fit alongside immunotherapy and other targeted agents. The discussion covers everything from biomarker-driven selection to the proactive management of toxicities like ILD and ocular effects, providing a roadmap for optimizing long-term sequencing and patient quality of life. An essential watch for oncology clinicians managing the integration of next-generation targeted therapies into modern clinical practice. 🎧 Watch more expert-led oncology conversations from CHM Conversations. #BreastCancer #LungCancer #NSCLC #ADC #AntibodyDrugConjugates #DatopotamabDeruxtecan #TrastuzumabDeruxtecan #TROP2 #HER2 #EGFR #TargetedTherapy #PrecisionOncology #MedicalOncology #ThoracicOncology #BreastOncology #Immunotherapy #CommunityHealthMedia – Thanks for watching! Our podcasts are also available on: • Spotify - https://spotf.fi/chm-podcast • Amazon Music - https://amazn.so/chm-podcast • Apple Podcast - https://podcasts.apple.com/us/podcast/community-health-media/id1837428248 • Castbox - https://castbox.fm/vh/6735434 • Goodpods - https://goodpods.com/profile/chm-111066 • iHeartRadio - https://iheart.com/podcast/291542082 • Pocket Casts - https://pca.st/3ncdh11o – Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences. We’re an integrated marketing company that produces world-class content and curated peer to peer live experiences. We specialize in: • Peer to peer interviews, panels & round-tables • Curated live events & conferences • Professional in-depth content & research updates • Interactive learning modules & webinars • Live & on-demand webcasts & podcasts Learn more about us here - https://communityhealth.media