Theory of Change: #1: How Alexander Berger weighs the world’s biggest problems

This Week in Global Dev: #148: The latest on the Ebola outbreak response

This week, we unpack the latest on the Ebola outbreak in the Democratic Republic of Congo and Uganda. With no approved vaccines or treatments for the Bundibugyo species driving the spread, we dive into the race to develop a vaccine and the critical funding shortfalls standing in the way. While pledges have been made, much of that support has yet to reach those affected on the ground. We also discuss the congressional hearings on Trump’s fiscal year 2027 foreign affairs budget request, which featured a debate on the Ebola crisis. With this being the first outbreak since the dismantling of USAID, we break down the United States’ approach to the health emergency. To dig into these stories and others, Business Editor David Ainsworth sits down with Senior Reporters Sara Jerving and Michael Igoe for the latest episode of our weekly podcast series. Check out Devex’s new podcast series Theory of Change: https://www.devex.com/focus/theory_of_change

Theory of Change: #1: How Alexander Berger weighs the world’s biggest problems

Coefficient Giving, one of the world’s largest effective-giving funders, is about to go even bigger. On the heels of its biggest funding year ever in 2025 — in which it channeled over $1 billion to highest-impact causes — the organization formerly known as Open Philanthropy and funded by Facebook cofounder Dustin Moskovitz and his wife Cari Tuna is eyeing annual growth upward of 50% and bringing on more staff to get it done. The person behind that vision is Alexander Berger, Coefficient Giving’s cofounder and CEO. Berger is in charge of turning Facebook wealth — and, increasingly, funds from other donors — into as many lives saved and improved as possible. The organization is a major funder in global health and development, catastrophic risk, research and innovation, and even farm animal welfare. Last week, Coefficient Giving launched a new pooled fund to tackle Group A Streptococcus — an easily treated disease that is still responsible for nearly 700,000 deaths a year — a cause that reflects the organization’s framework for tackling problems that are important, neglected, and tractable. In a rare, in-depth interview with Devex Senior Reporter Michael Igoe, Berger sheds light on Coefficient Giving’s rapid growth plans, its strategy for choosing high-impact causes, the rise of artificial intelligence philanthropy, and his own approach to affecting change in an uncertain world. This is the first episode of Theory of Change, a new podcast series from Devex featuring candid interviews with leaders shaping the future of global development.

This Week in Global Dev: #147: Can domestic resources and private capital fund development?

In this episode, we look back at the conferences we reported from over the past few weeks, reflecting on how global development narratives are evolving across both the global north and the global south. With traditional donors stepping back, the African Development Bank is using its annual meetings to urge governments to fix tax inefficiencies and better mobilize domestic resources to drive sustainable economic development. We found similar themes at the OECD’s Future of Development Co-Operation conference in Paris and the Global Partnerships Conference in London, where unlocking private capital and prioritizing country-led development emerged as key talking points. To analyze these trends, Senior Reporter Adva Saldinger sits down with Business Editor David Ainsworth and Global Development Reporter Ayenat Mersie for the latest episode of our weekly podcast series. Sign up to Devex Invested: https://www.devex.com/newsletters/invested

This Week in Global Dev: #146: Live from the World Health Assembly

Filmed live from Geneva, Switzerland, on the sidelines of the World Health Assembly, this episode of This Week in Global Development delves into the critical debates unfolding on the ground in Geneva. That includes the tense atmosphere following the World Health Organization’s rare decision to proclaim a global health emergency over the latest Ebola outbreak, mounting fears regarding the virus tracking into dense urban centers, and how containment efforts are hindered by strict funding restrictions that leave the vast majority of voluntary budgets tied up. The discussion also looks at the highly anticipated — yet heavily criticized — joint strategy to reform global health infrastructure, capturing the frustration of analysts who feel the plan avoids essential conversations about institutional mergers. The behind-the-scenes maneuvering for the next WHO director-general selection enters the conversation as well, along with the complex legislative hurdles facing the African Medicines Agency as it strives to secure pharmaceutical independence across the continent.

Special edition: Early detection in Brazil is a game changer for lung cancer care

In a special edition of the This Week in Global Development podcast, Devex cofounder and Executive Vice President Alan Robbins sits down with Brazilian thoracic surgeon Dr. Ricardo Sales do Santos to discuss a revolutionary approach to tackling lung cancer in medically underserved communities in Brazil.   As the most lethal form of cancer globally, lung cancer often goes undetected until its final stages, but Dr. Santos and the Bristol Myers Squibb Foundation (are working to change that narrative through a combination of mobile technology and local capacity building. By bringing advanced CT scanning units directly into high-risk, low-income communities, they are catching tumors when they are small and potentially curable, fundamentally shifting the odds for thousands of patients.   The conversation also touches on the logistical and cultural hurdles of delivering specialized oncology care to remote areas. Dr. Santos highlights the importance of “bringing the clinic to the patient,” utilizing mobile CT units and telemedicine to bridge the gap in healthcare access. Beyond the technology, the success of the program relies heavily on empowering local health workers and community members to recognize early cancer warning signs and overcome the stigma associated with a cancer diagnosis. This approach not only improves individual health outcomes but also strengthens the broader healthcare system, offering a scalable model for global health initiatives.   To learn more about sustainable improvements in cancer care and get a compelling look at how local solutions can drive global change, listen to this special edition of This Week in Global Development. For more international development news, visit: http://www.devex.com Visit  Strengthening Care Systems — a series raising awareness of the scale of the global lung cancer burden and the systems-level changes required to address it: https://pages.devex.com/strengtheningcaresystems.html