#18 - Ian Weimer: Unlocking Value Through Real World Evidence in the New FDA Era

#18 - Ian Weimer: Unlocking Value Through Real World Evidence in the New FDA Era

Recorded in-person in Minneapolis, this conversation reflects the kind of cross-regional connections shaping the Midwest’s medtech and biotech ecosystem. In this episode of Favorable Environments, Tung Nguyen speaks with Ian Weimer, Founder of Weimer Analytics, about bringing real world evidence and advanced health economics analytics to small and medium-sized medtech and biotech companies.  Ian brings experience from a boutique healthcare consultancy where he contributed to 16 peer-reviewed publications and regulatory submissions for Fortune 500 pharma and medical device firms—to launching his own firm in 2025 to fill a clear gap: making sophisticated, tailored evidence generation accessible beyond large incumbents. The conversation explores how real world evidence (RWE) is helping early-stage innovators quantify disease burden, demonstrate product value before launch, and attract investment in a challenging funding environment.  Ian also breaks down the FDA’s December 2025 guidance update, which is far more accepting of de-identified real world data for initial approvals—a shift he expects to accelerate adoption across early-stage companies. He also discusses how AI is acting as a multiplier for smaller firms, turning months-long analyses into work that can now be completed in hours or days. This episode offers a grounded look at how real-world evidence and data science are leveling the playing field for the next generation of healthcare innovators—and why the Midwest continues to create favorable environments for evidence-based entrepreneurship and commercialization. To stay connected with the USD Discovery District, follow us on LinkedIn at linkedin.com/company/usd-discovery-district [http://linkedin.com/company/usd-discovery-district] and discover opportunities at usddiscovery.com [https://www.usddiscovery.com/building1/?utm_source=podcast&utm_medium=favorable-environments&utm_campaign=organic&utm_content=ep-15], including leasing at Building 1 for research, diagnostics, and advanced manufacturing.  Favorable Environments is presented by the USD Discovery District and supported by South Dakota First Capital [https://www.southdakotafirst.com/], working to expand access to capital for companies building the future of bioscience in the region. Disclaimer: This podcast serves solely for general informational purposes and does not represent the provision of medical, nursing, or other professional healthcare services, including the rendering of medical advice. Users access and utilize the information and linked materials at their own discretion and risk. The material presented herein is not intended as a replacement for professional medical advice, diagnosis, or treatment. Individuals should neither ignore nor postpone seeking qualified medical guidance for any health concerns and are strongly encouraged to consult their healthcare providers promptly for personalized evaluation and care.

#17 - Dr. Patrick Hogan: Building Awareness Against the Silent Pandemic of Antimicrobial Resistance

In this episode of Favorable Environments, Tung Nguyen speaks with Dr. Patrick Rynn Hogan, DHA, author of the newly published book The Silent Pandemic of Antimicrobial Resistance: Why the Next Global Health Crisis Has Already Begun and CEO of Prescient Healthcare, about one of the most urgent yet under-recognized threats to modern health. Dr. Hogan explains antimicrobial resistance (AMR) as a system-level failure spanning healthcare infrastructure, agricultural practices, supply chains, and innovation pipelines—where once-treatable infections like UTIs, sepsis, and minor wounds now contribute to hundreds of thousands of deaths annually as microbes evolve beyond standard antibiotics. The conversation delves into key drivers of AMR: widespread antibiotic use in livestock (accounting for about 60% of global consumption), leading to environmental dissemination through soil, water, and food systems; post-COVID strains on rural hospitals and access gaps in states like South Dakota; and the stagnation in new antibiotic development due to limited profitability and reimbursement challenges. Dr. Hogan highlights South Dakota's moderate-risk profile—strong statewide reporting to the CDC and proactive health systems balanced against higher prescribing rates and rural geography—and the interconnected ecosystem risks amplified in agriculture-heavy regions. Drawing on historical pandemics and today's hyper-connected world, he stresses preparedness through everyday actions (completing full antibiotic courses, rigorous hygiene, proper food handling), better surveillance and transparent reporting (often masked under sepsis or UTI labels), and accelerated innovation in therapeutics, data tools, and AI for analysis and decision support. Dr. Hogan views AMR as a ripe field for disruption, calling for pharma investment, improved communication, and interdisciplinary collaboration to avert a future where resistant infections rival cancer in mortality. This episode offers a grounded look at why awareness and proactive steps matter now—as populations age and vulnerabilities rise—and how South Dakota's tight networks, statewide support, and emerging bioscience ecosystem create scalable advantages for addressing rural health challenges, advancing diagnostics and treatments, and building long-term resilience. The discussion underscores the USD Discovery District's role as a conduit for university research, private sector ambition, and community impact in fostering favorable environments for mission-driven innovation in biotech, medtech, and global health security. To stay connected with the USD Discovery District, follow us on LinkedIn at linkedin.com/company/usd-discovery-district [http://linkedin.com/company/usd-discovery-district] and discover opportunities at usddiscovery.com [https://www.usddiscovery.com/building1/?utm_source=podcast&utm_medium=favorable-environments&utm_campaign=organic&utm_content=ep-15], including leasing at Building 1 for research, diagnostics, and advanced manufacturing.  Favorable Environments is presented by the USD Discovery District and supported by South Dakota First Capital [https://www.southdakotafirst.com/], working to expand access to capital for companies building the future of bioscience in the region. Disclaimer: This podcast serves solely for general informational purposes and does not represent the provision of medical, nursing, or other professional healthcare services, including the rendering of medical advice. Users access and utilize the information and linked materials at their own discretion and risk. The material presented herein is not intended as a replacement for professional medical advice, diagnosis, or treatment. Individuals should neither ignore nor postpone seeking qualified medical guidance for any health concerns and are strongly encouraged to consult their healthcare providers promptly for personalized evaluation and care.

#16 - Sharing the Inside View: Reflections from the USD Discovery District Team

In this episode of Favorable Environments, Host Tung Nguyen speaks with fellow members of theUSD Discovery District leadership team—Ryan, President; Marc, Director of Biotech Development; in a reflective discussion—about the organization's first operational year since taking possession of Building 1 in January 2025. The team shares candid insights into the milestones achieved, the challenges navigated, and the strategic pivots that have positioned the District as a purpose-built hub for bioscience and life sciences innovation in Sioux Falls. The conversation explores the pragmatic realities of building a research park from the ground up: from refining tenant profiles to prioritize research-oriented companies, to developing a resource-mapping platform that connects prospects with statewide assets in academia, healthcare, and industry. Ryan, Marc, and Tung reflect on lessons from early tenant engagements, the value of an abundance mindset in partnerships, and how South Dakota's low-density networks and statewide support create scalable advantages for commercialization and long-term growth. They discuss the importance of relationships as infrastructure—beyond buildings—and how collaborations with entities such as the University of South Dakota, Forward Sioux Falls, and regional healthcare systems drive momentum. Later in the episode, the team addresses the cultural evolution of a small, agile group, the need for disciplined filtering of opportunities, and the vision for future phases, including alpha and beta testing of the resource-mapping tool and its potential as a standalone platform. The discussion highlights why the USD Discovery District serves as a conduit between university research, private sector ambition, and community impact, advancing applied research, talent pipelines, and bioscience scaling in a region built for resilience. This episode provides an inside look at the disciplined progress behind South Dakota's emerging bioscience campus and why the USD Discovery District continues to create favorable environments for mission-driven innovation, partnerships, and economic impact. To stay connected with the USD Discovery District, follow us on LinkedIn at linkedin.com/company/usd-discovery-district [http://linkedin.com/company/usd-discovery-district] and discover opportunities at usddiscovery.com [https://www.usddiscovery.com/building1/?utm_source=podcast&utm_medium=favorable-environments&utm_campaign=organic&utm_content=ep-15], including leasing at Building 1 for research, diagnostics, and advanced manufacturing.  Favorable Environments is presented by the USD Discovery District and supported by South Dakota First Capital [https://www.southdakotafirst.com/], working to expand access to capital for companies building the future of bioscience in the region.

#15 - Dr. Kristina Harris Jackson: Measuring What Matters

In this episode of Favorable Environments, Tung Nguyen speaks with Dr. Kristina Harris Jackson, Director of Research at OmegaQuant Analytics, about how a science-first company in Sioux Falls became a global leader in fatty acid testing. Kristina shares the story of OmegaQuant’s founding, the research legacy of Dr. Bill Harris, and how the company grew from an academic idea into one of the most trusted diagnostic tools in the world. With more than a million Omega-3 Index tests performed, partnerships with universities and clinics across more than seventy countries, and a CLIA-certified laboratory headquartered in South Dakota, OmegaQuant has brought evidence-based nutritional analytics into everyday life in a way few companies have achieved. The conversation explores why fatty acid testing matters, what the Omega-3 Index can reveal about long-term health, and how a simple dried blood spot sample opened the door to global adoption. Kristina reflects on the early days of building a diagnostics business, the challenge of translating complex research into accessible products, and the questions customers ask when they want to understand whether their lifestyle choices are making a real impact. Kristina talks about affordability, accuracy, and the emotional dimension of helping people understand their own physiology through personalized data rather than guesswork. Later in the episode, producer Ngoc Thach reflects on how she first met Kristina through her TEDx Sioux Falls presentation [https://youtu.be/jjC3ucoqXk4?si=e0SCMB246Lcz2xnr], a moment that highlighted Kristina’s ability to bridge scientific rigor with clear, human storytelling. Kristina shares what it means to communicate science to audiences encountering this information for the first time, and why public understanding is now central to advancing nutrition and health research. This episode offers a close look at how a South Dakota company is shaping the future of personalized nutrition and why the region’s growing bioscience ecosystem continues to create favorable environments for science translation and global impact. To learn more about OmegaQuant, visit omegaquant.com [http://omegaquant.com] and explore their educational resources, including OmegaQuant University [https://omegaquant.com/omegaquant-university/] and the OmegaMatters Broadcasts [https://omegaquant.com/omegamatters-broadcasts/]. To stay connected with the USD Discovery District, follow us on LinkedIn at linkedin.com/company/usd-discovery-district [http://linkedin.com/company/usd-discovery-district] and discover opportunities at usddiscovery.com [https://www.usddiscovery.com/building1/?utm_source=podcast&utm_medium=favorable-environments&utm_campaign=organic&utm_content=ep-15], including leasing at Building 1 for research, diagnostics, and advanced manufacturing.  Favorable Environments is presented by the USD Discovery District and supported by South Dakota First Capital [https://www.southdakotafirst.com/], working to expand access to capital for companies building the future of bioscience in the region. Host: Tung Nguyen, Thel Consulting Audio/Video: Skye Giebink, Skye Video Producer: Ngoc Thach, Mix Maker Disclaimer: This podcast serves solely for general informational purposes and does not represent the provision of medical, nursing, or other professional healthcare services, including the rendering of medical advice. Users access and utilize the information and linked materials at their own discretion and risk. The material presented herein is not intended as a replacement for professional medical advice, diagnosis, or treatment. Individuals should neither ignore nor postpone seeking qualified medical guidance for any health concerns and are strongly encouraged to consult their healthcare providers promptly for personalized evaluation and care.

#14 - Fabrice Paublant: Cooling the Future with Liquid Ventilation

Today, we sit down with Fabrice Paublant, CEO of Orixha, whose 30-year career in pharmaceuticals and consulting drives his passion for transformative medical innovation. In this episode, Mr. Paublant dives into Orixha’s pioneering liquid ventilator for post-cardiac arrest care, sharing insights on leadership, mentorship, and strategic cash management. The content in this episode is not financial or legal advice. Please consult a qualified professional for investment guidance. This podcast is sponsored by the USD Discovery District and South Dakota First Capital. “I am mindful that scientific achievement is rooted in the past, is cultivated to full stature by many contemporaries and flourishes only in favorable environment.” - Ernest O. Lawrence. Ernest Lawrence was an American nuclear physicist and the winner of the Nobel Prize in Physics in 1939 for his invention of the cyclotron. He was born and educated in South Dakota. In 2023, he was portrayed in the Christopher Nolan film, 'Oppenheimer,' which explores the life of J. Robert Oppenheimer and the development of the atomic bomb, a project to which Lawrence significantly contributed. EPISODE LINKS: Orixha: https://orixha.com [https://orixha.com] USD Discovery District: https://www.usddiscovery.com/ [https://www.usddiscovery.com/] South Dakota First Capital: https://www.southdakotafirst.com/ [https://www.southdakotafirst.com/] Favorable Environments: https://favorableenvironments.com/ [https://favorableenvironments.com/] USD Discovery District Leasing: https://www.usddiscovery.com/lease [https://www.usddiscovery.com/lease] Disclaimer: This podcast serves solely for general informational purposes and does not represent the provision of medical, nursing, or other professional healthcare services, including the rendering of medical advice. Users access and utilize the information and linked materials at their own discretion and risk. The material presented herein is not intended as a replacement for professional medical advice, diagnosis, or treatment. Individuals should neither ignore nor postpone seeking qualified medical guidance for any health concerns and are strongly encouraged to consult their healthcare providers promptly for personalized evaluation and care.