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Dr Valter Longo is a longevity researcher who developed the fasting-mimicking diet, and this conversation reveals why 16-hour fasting increases mortality risk, how true autophagy takes five full days to activate, and why high protein might be accelerating ageing. Valter explains why skipping breakfast and 16-hour fasting correlates with higher cardiovascular disease, despite faster results, 12-hour eating windows show zero negatives in studies. Learn why the five-day FMD uses low protein and high fat to trigger fasting while feeding gut bacteria, how less than 10% of people reach age 70 disease-free, and why blocking growth hormone pathways makes organisms live dramatically longer. 00:00 Daily fasting duration recommendations 04:02 Development of the fasting-mimicking diet (FMD) 10:30 Concerns about water-only fasting effects 14:07 Application of FMD for disease prevention and longevity 21:51 Completing the fasting cycle with proper refeeding 25:09 The debate on protein sources and intake 32:48 Protein intake for muscle growth and longevity 38:16 The relationship between strength training and longevity 50:20 Stress and its interaction with food and health 54:35 Key lifestyle factors influencing longevity DISCLAIMER Nothing shared on this podcast is a substitute for professional medical guidance. Please consult a healthcare professional before making any health or lifestyle changes. Hack You Media → Instagram: https://www.instagram.com/hackyoumedia/ [https://www.instagram.com/hackyoumedia/] → TikTok: https://www.tiktok.com/@hack.you.media?lang=en [https://www.tiktok.com/@hack.you.media?lang=en] → More from Hack You: https://hackyou.media/#aa19104a-abc1-4697-b0f5-0e81e47e60c5 [https://hackyou.media/#aa19104a-abc1-4697-b0f5-0e81e47e60c5] » Follow Vadim« Instagram: https://www.instagram.com/vadim_bioniq/?hl=en [https://www.instagram.com/vadim_bioniq/?hl=en] Bioniq: https://www.bioniq.com/ [https://www.bioniq.com/] » Follow Mike« YouTube: youtube.com/MikeThurston Instagram: https://www.instagram.com/mikethurston/?hl=en [https://www.instagram.com/mikethurston/?hl=en] First Things THRST: YouTube.com/FirstThingsThrst » Follow Valter« Instagram: https://www.instagram.com/prof_valterlongo/?__d=1%252F [https://www.instagram.com/prof_valterlongo/?__d=1%252F] Website: https://valterlongo.com/ [https://valterlongo.com/]
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