Perspective X with Pauline Fetaui
Win $2,000 in credits with the Day One Network — take our 2-minute audience survey before 30 June: dayone.fm/survey EPISODE SUMMARY From surgeon to psychiatrist, Bitcoin investor to billion-dollar crypto brokerage founder, Dr. Prash Puspanathan has lived one of the most unconventional founder journeys in tech. After co-founding and scaling Caleb & Brown into a global crypto powerhouse, later acquired by SwiftX in 2025, Dr. Prash is now pioneering the future of mental health with Enosis Therapeutics, using VR to transform psychedelic-assisted therapy integration. In this episode of Perspective X, Dr. Prash shares how a single psilocybin experience completely reshaped his worldview, steering him away from surgery and into psychiatry, entrepreneurship, and eventually, crypto. He reveals the parallels between fiscal freedom in decentralized finance and cognitive freedom in mental health, the scrappy early days of arbitrage trading, and the challenges of scaling a white-glove brokerage to serve high-net-worth clients worldwide. We also dive into the future of psychedelic medicine, why integration is the “real work,” how technology can lower costs and increase access, and why prevention, not just treatment, will define the next era of mental health. From paradigm-shifting psychedelics to building billion-dollar ventures, this is a conversation about liberation, of thought, finance, and human potential. TIME STAMPS 00:00 – Intro: Dr. Prash’s unconventional founder journey 02:00 – From surgery to psychiatry: psychedelics as a turning point 06:30 – The transformative psilocybin experience and shifting paradigms 10:30 – Understanding psychedelic therapy and integration work 16:00 – Why psychedelics challenge power structures and cultural norms 22:00 – Fiscal freedom and cognitive freedom: psychedelics and Bitcoin 30:00 – Founding Caleb & Brown and building a billion-dollar brokerage 37:00 – Global scaling, high-net-worth clients, and leadership transitions 42:00 – Preparing for acquisition: the 9-month journey to SwiftX 50:00 – Running a dual life as psychiatrist and founder 55:00 – Enosis Therapeutics: VR-powered integration for psychedelic therapy 01:02:00 – Building tools for patients, therapists, and the future of mental health 01:10:00 – The vision for a psychological digital twin 01:15:00 – Psychedelics in the next 10–50 years: from treatment to prevention 01:20:00 – Translating research into real-world impact and future mission RESOURCES 💰 Caleb & Brown – Global crypto brokerage: https://calebandbrown.com 🩺 Enosis Therapeutics – Tech for psychedelic-assisted therapy: https://www.enosistherapeutics.com/ 👤 Dr. Prash on LinkedIn: https://www.linkedin.com/in/drprash/ SPONSORS: PERSPECTIVE X IS SUPPORTED BY OUR WONDERFUL SPONSORS: Deel: Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, and get visas handled fast, so you stay focused on scaling. Deel takes care of onboarding, HR, IT, EOR, benefits, and compliance, so your team can grow without borders. It’s why more than 40,000 fast-growing companies trust Deel to move fast. Visit https://www.deel.com/dayone PERSPECTIVE X IS PART OF DAY ONE. DAY ONE HELPS FOUNDERS AND STARTUP OPERATORS MAKE BETTER BUSINESS DECISIONS MORE OFTEN. To learn more, join our newsletter [https://dayone.fm/newsletter] to be notified of new Perspective X episodes and upcoming shows. Mentioned in this episode: Mighty Partners_PX_May 2025 Deel x PX_Script 1 Vanta_PX_May 2025
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