Effects of Dapagliflozin in Patients With Chronic Kidney Disease, With and Without Heart Failure

Effects of Dapagliflozin in Patients With Chronic Kidney Disease, With and Without Heart Failure

In this podcast based on the ESC 2021 poster, 'Effects of Dapagliflozin in Patients With Chronic Kidney Disease, With and Without Heart Failure', Prof John McMurray (University of Glasgow, UK) provides a comprehensive overview of the study's background, methods and results. Previous studies have demonstrated that sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of heart failure (HF) hospitalisation in patients with type 2 diabetes, including in those with chronic kidney disease (CKD). This reduced risk is also evident in patients with HF or CKD with or without type 2 diabetes. In the DAPA CKD study, the authors examined the outcomes in patient with CKD with and without type 2 diabetes by history of HF at baseline. Here, the poster authors conclude that dapagliflozin reduced the risk of adverse kidney outcomes, hospitalisation for HF or cardiovascular death, and prolonged survival in people with CKD, with or without type 2 diabetes, independent of history of HF.