The Founder Mindset
David de Graaf never intended to become a biotech Founder, but a confluence of circumstances led him from academia into the startup world. A geneticist by training, David shares how financial needs and a desire for more agility in scientific application prompted his shift into industry. He likens big pharma to freight trains (efficient but hard to steer) and highlights the appeal of startups as nimble, innovation-driven environments. At Reverb Therapeutics, David and his Co-Founder Surjit Dixit are combining bi-specific antibodies with immune system signals to improve cancer treatment outcomes. Their lead program, AMPA-1, aims to amplify natural immune signals locally, using the immune system's own cytokines to better target tumors. With early data showing promise, Reverb is preparing for a major fundraising round to push the treatment into clinical trials. David also discusses the emotional resilience needed to be a Founder. He emphasizes the importance of therapy, mentorship, and learning from failure. For David, the ultimate reward isn't financial but the potential to dramatically improve patient lives, a mission that continues to fuel his entrepreneurial journey. About David de Graaf David de Graaf is the Co-Founder and CEO of Reverb Therapeutics, a biotech company focused on enhancing immune system signals to improve cancer treatments. A geneticist by training, David previously held roles in academia and at large pharmaceutical companies before founding multiple biotech ventures. His work has contributed to several drugs that are now either marketed or in late-stage trials, reflecting a rare success rate in drug development. Resources discussed in this episode: * Miracle and Wonder: Conversations with Paul Simon, created and narrated by Malcolm Gladwell [https://www.audible.ca/pd/Miracle-and-Wonder-Audiobook/B09J1KRSGG] The Founder Mindset is Sponsored By: 1. ATB [http://www.atb.com/tech] 2. API [https://appliedpharma.ca/] 3. Artemis [https://www.artemiscanada.com/] 4. OCIF [https://www.opportunitycalgary.com/] — Contact Thin Air Labs: * Website: ThinAirLabs.ca [http://thinairlabs.ca] * LinkedIn: Thin Air Labs [https://www.linkedin.com/company/thin-air-labs/] * X: Thin Air Labs [https://twitter.com/thinair_labs] * YouTube: Thin Air Labs [https://www.youtube.com/channel/UCHQyu5u8nMnIpw9e72boUAg] Contact David de Graaf: * Reverb Therapeutics [https://www.reverbtx.com/] * Linkedin: David de Graaf [https://www.linkedin.com/in/davidd12/] Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com [https://pcm.adswizz.com] for information about our collection and use of personal data for advertising.
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