Degrees of Health

Dr. Mark Tarnopolsky is a world-renowned expert in mitochondrial health, muscle function, and ageing science. As a clinician-scientist at McMaster University, he has dedicated his career to understanding how we can optimise our mitochondria - the tiny powerhouses in our cells - for better energy, performance, and longevity. This is for you if you’ve ever asked yourself: Why does energy fade as I age? How can I boost my endurance, strength, and resilience whatever age I am? And what are the best ways to support (even enhance) these powerhouses naturally? We cover: 🔥 Mitochondria 101 - why they’re central to health, ageing, and energy production 🌟 Signs of mitochondrial dysfunction - fatigue, muscle loss, and cataracts 🏋️‍♀️ Exercise for mitochondria – Endurance vs. resistance training benefits (on mitochondrial mass and function) 💡 Mitochondrial Biogenesis - how to double your mitochondria in 3 months 🍎 Supplements demystified - the science on CoQ10, NAD precursors, beetroot extract, and urolithin A 🧠 Aging & oxidative stress - mitophagy and why antioxidants alone won’t cut it 🩺 Mark’s regimen - he practices what he preaches: the nutrition, supplements, and exercise strategies he uses to stay on top of his game (and hold a +68 VO2 max in his 60s) What we do know? There’s no shortcut to better mitochondria. What we can do? We listen and we learn what Dr Mark describes to be the gold standard for optimising energy, longevity, and quality of life. Lace up your sneakers, team! Find Dr Mark: McMaster University [https://mira.mcmaster.ca/our-faculty/mark-tarnopolsky/] Supplement Brand - Stay Above Nutrition [https://stayabovenutrition.ca/ ] Mark’s papers [https://www.researchgate.net/profile/Mark-Tarnopolsky ] Mentioned in this episode: Antioxidants prevent health-promoting effects of physical exercise in humans [https://www.pnas.org/doi/10.1073/pnas.0903485106 ] PubMed [https://pubmed.ncbi.nlm.nih.gov/] Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and [https://academic.oup.com/jcem/article/104/11/5703/5544497?login=false ] Incretin Hormones in Nondiabetic Men With Obesity A randomized placebo-controlled clinical trial of nicotinamide riboside [https://www.sciencedirect.com/science/article/pii/S0002916522029409?via%3Dihub ] in obese men Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health [https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00158-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666379122001586%3Fshowall%3Dtrue ] Want to watch this on video? Subscribe on YouTube [https://www.youtube.com/channel/UCDpVgBgbtgoNBz3sRQauH5w] Instagram  @degreesofhealth [https://www.instagram.com/degrees_of_health/] Disclaimer [https://www.canva.com/design/DAF6uea0cwE/S6IFQR7g0IoRiQiRkAIDyA/view?utm_content=DAF6uea0cwE&utm_campaign=designshare&utm_medium=link&utm_source=viewer] ---------------------------------------- Hosted on Acast. See acast.com/privacy [https://acast.com/privacy] for more information.

The light we see is as crucial as the food we eat, the water we drink, and the air we breathe. Former Harvard Medical School professor and 40-year leading expert in circadian clocks and human health, Dr. Moore-Ede speaks on why our health hinges on getting the right sort of light at the right time. In this episode, he reveals the dangers of modern LED lighting, which often emits bright but unhealthy "junk light." Just as junk food wreaks havoc on our body, junk light disrupts our circadian rhythms, suppresses melatonin, and contributes to chronic diseases. We cover: 💤 The Health Risks of LED Lighting: "junk light" disrupts circadian rhythms, suppresses melatonin, and contributes to chronic diseases 💡 Junk Light and Lumens - modern lighting regulations prioritise energy efficiency over human health 🕒 Circadian Clocks and Longevity: light is essential for disease prevention and healing 👓 Rise of Myopia in Children: indoor living and reduced exposure to natural light are fueling skyrocketing rates of myopia 🌈 Blue light blocking glasses - do you have the right sort? 🛠️ Practical Solutions for Healthier Lighting: simple changes you can make in your home and your life Backed by decades of evidence, Dr Martin Moore-Ede shares the science behind why we must prioritise light in our health, and how to optimise our exposure for immediate benefits, and a longer, healthier life. Find Dr Martin: Book [https://www.amazon.com/Light-Doctor-Martin-Moore-Ede/dp/B0D54SHWS4]: https://thelightdoctor.com/ [https://thelightdoctor.com/] Website and Campaign [https://circadianlight.org/] Substack [lightdoctormartinmooreede.substack.com] LinkedIn [https://www.linkedin.com/in/martin-moore-ede-80630a12/] Instagram [https://www.instagram.com/circadianlightdoctor/] Twitter [https://twitter.com/DrMooreEde/] YouTube [https://www.youtube.com/@drmartinmoore-ede1539] Google Scholar [https://scholar.google.com/citations?user=lFyCIC0AAAAJ&hl=en] Mentioned in this episode: Health and Light [https://amzn.to/4jdO36v ] by John Ott SORAA [https://www.soraa.com/ ] - light bulbs The Body Electric [https://amzn.to/4gRiQET] by Robert Becker and Gary Seldon Avoidance of sun exposure is a risk factor [https://onlinelibrary.wiley.com/doi/10.1111/joim.12251 ] for all-cause mortality: results from the Melanoma in Southern Sweden cohort Want to watch this on video? Subscribe on YouTube [https://www.youtube.com/channel/UCDpVgBgbtgoNBz3sRQauH5w] Instagram  @degreesofhealth [https://www.instagram.com/degrees_of_health/] Disclaimer [https://www.canva.com/design/DAF6uea0cwE/S6IFQR7g0IoRiQiRkAIDyA/view?utm_content=DAF6uea0cwE&utm_campaign=designshare&utm_medium=link&utm_source=viewer] ---------------------------------------- Hosted on Acast. See acast.com/privacy [https://acast.com/privacy] for more information.

Here we're speaking with Dr. Joseph Cullen as he discusses his research on high dose intravenous (IV) vitamin C as a treatment for metastatic cancer. The aim in his lab is to show that adding high-dose, IV vitamin C, which is very inexpensive and very well tolerated, can improve treatment for these cancers that are among the deadliest. Joseph highlights the potential for it to transform not just patient outcomes but the entire conversation around alternative therapies. He shares candid insights from his lab’s work on glioblastoma, lung cancer, and pancreatic cancer, as well as ongoing studies into combining vitamin C with other treatments like immunotherapy and radiation. We cover: 💡 What makes high-dose IV vitamin C a game - changer in cancer care 📈 Cancer progression and survival outcomes - his research that shows doubling progression-free survival 🔍 Mechanisms of action - pro-oxidant in cancer cells, antioxidant in healthy cells 👩‍⚕️ Challenges in acceptance - why some oncologists remain skeptical 🩺 Who benefits most - which cancers respond best, combining therapies, and where it doesn’t work ⚠️ Side effects and safety - what to watch for, including rare risks The research shows significant promise, but challenges persist. Joseph opens up about the difficulties in securing funding for anything outside pharma-driven drugs and compounds, the skepticism from traditional oncology, and the need for more extensive clinical trials to validate findings. Despite these hurdles, his belief in the therapy’s potential remains steadfast - and his surprise at just how well it works, over and over again, keeps driving him forward. Mentioned in this episode: High-dose IV vitamin C plus chemotherapy [https://www.eurekalert.org/news-releases/1065277 ] doubles survival in advanced pancreatic cancer A randomized trial of pharmacological ascorbate, gemcitabine, and nab-paclitaxel for metastatic pancreatic cancer [https://www.sciencedirect.com/science/article/pii/S2213231724003537?via%3Dihub] What is metastatic pancreatic cancer? [https://www.moffitt.org/cancers/pancreatic-cancer/faqs/what-is-metastatic-pancreatic-cancer/#:~:text=Metastatic%20pancreatic%20cancer%20is%20cancer,is%20not%20considered%20liver%20cancer] Find Joseph: joseph-cullen@uiowa.edu - Joseph kindly said that oncologists can reach out to him directly to enquire more and request the protocol for patients where appropriate All Dr Cullen’s papers [https://www.scopus.com/authid/detail.uri?authorId=7201996527 ] Free Radical & Radiation Biology [https://biomed.medicine.uiowa.edu/subprograms/free-radical-radiation-biology#:~:text=It%20is%20a%20PhD%20program,of%20scientists%20in%20the%20field] Want to watch this on video? Subscribe on YouTube [https://www.youtube.com/channel/UCDpVgBgbtgoNBz3sRQauH5w] Instagram  @degreesofhealth [https://www.instagram.com/degrees_of_health/] Disclaimer [https://www.canva.com/design/DAF6uea0cwE/S6IFQR7g0IoRiQiRkAIDyA/view?utm_content=DAF6uea0cwE&utm_campaign=designshare&utm_medium=link&utm_source=viewer] ---------------------------------------- Hosted on Acast. See acast.com/privacy [https://acast.com/privacy] for more information.

Meet Professor Thomas Seyfried, the biologist leading a revolution in how we fight cancer and other chronic diseases with metabolic therapies. Author of the acclaimed book 'Cancer as a Metabolic Disease', Professor Seyfried talks through the evolutionary biology behind cancer and the scientific evidence that disproves the consensus theory on the origin of cancer. His focus on the need for mitochondrial health and metabolic therapies opens up the conversation for new avenues of treatment that are less toxic and, quite possibly, more effective. We cover (+much more): 🥬 How cancer cells thrive on fermentation - and how this changes treatment approaches 📉 The future of cancer care - rethinking research, funding, and patient education 🥩 Ketogenic diets and cancer 💊 Glutamine inhibitors and parasite drugs - tools with potential in fighting metastatic cancer ⚠️ The cost of traditional care - understanding why metabolic therapies may work better than or in addition to SOC 🌍 Why mitochondrial health matters – for cancer, diabetes, Alzheimer’s, and more Professor Seyfried is astounded by how many cancer patients start to use metabolic therapy only after they've exhausted all other options and they haven't worked. He believes the first thing you need to do is get your body into NK, whatever treatment you choose. For patients, researchers, and anyone interested in the future of cancer care, this episode presents the latest metabolic science and the latest framework for cancer prevention and treatment strategies. You have to ask - are we literally tripping over the truth here? Find Thomas: Website [https://tomseyfried.com/ ] Twitter [https://x.com/tnseyfried?lang=bn ] YouTube [https://www.youtube.com/@talkingcancer-u4k ] Book [https://amzn.to/4gG7F16 ] - Cancer as a Metabolic Disease All of Professor Seyfried's published work [https://pubmed.ncbi.nlm.nih.gov/?term=thomas+seyfried] Mentioned: Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma [https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-024-03775-4 ] Amino Acid and Glucose Fermentation [https://www.tandfonline.com/doi/full/10.1080/17590914.2024.2422268 ] Maintain ATP Content in Mouse and Human Malignant Glioma Cells Press-pulse: [https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-017-0178-2#:~:text=The%20press%2Dpulse%20therapeutic%20strategy,energy%20metabolism%20of%20normal%20cells. ] a novel therapeutic strategy for the metabolic management of cancer Want to watch this on video? Subscribe on YouTube [https://www.youtube.com/channel/UCDpVgBgbtgoNBz3sRQauH5w] Instagram  @degreesofhealth [https://www.instagram.com/degrees_of_health/] Disclaimer [https://www.canva.com/design/DAF6uea0cwE/S6IFQR7g0IoRiQiRkAIDyA/view?utm_content=DAF6uea0cwE&utm_campaign=designshare&utm_medium=link&utm_source=viewer] ---------------------------------------- Hosted on Acast. See acast.com/privacy [https://acast.com/privacy] for more information.

LJ Amaral dives us deep into the world of metabolic therapies and the ketogenic diet as a potential treatment for cancer. LJ shares valuable insights into the promising intersection of diet and cancer care and her pioneering research in the field makes this a must-listen for anyone interested in personalised cancer treatments and improving quality of life through dietary changes. We cover (but so much more too): 📖 The Warburg theory - understanding a cancer cells’ glucose dependence 🥑 Getting the fat equation right - omega-3s, whole fats, and tips for sticking to a high-fat diet. And why fat matters more than protein here... 🫒 Keto vs. Keto for cancer - dramatic tumour reductions and improved patient-reported outcomes in fatigue and cognition 💡 Future research - ketosis thresholds, 428 ongoing clinical trials, and personalised metabolic therapies 🩺 Patient-centered care in cancer treatment - respecting choices while providing evidence-backed support 🌟 BHB and inflammation - how ketones stabilise damaged cells and improve outcomes LJ Amaral’s commitment to extending healthspan and improving quality of life shines through. Her belief in the importance of maintaining hope and collaboration between patients and clinicians is inspiring. Find LJ: Research Gate [https://www.researchgate.net/profile/Lj-Amaral ] Mentioned in this episode: Keto Nutrition.org [Keto Nutrition.org] - also see our episode with Dom D’Agostino Charlie Foundation [https://www.cureepilepsy.org/personal-stories/charlies-story/] Keto Mojo [https://shop.uk.keto-mojo.com/ ]by Miriam Kalamian Tools of Titans [https://amzn.to/4gd2JRB ] by Tim Ferriss Untethered Soul [https://amzn.to/3OPqrre] by Michael Singer Want to watch this on video? Subscribe on YouTube [https://www.youtube.com/channel/UCDpVgBgbtgoNBz3sRQauH5w] Instagram  @degreesofhealth [https://www.instagram.com/degrees_of_health/] Disclaimer [https://www.canva.com/design/DAF6uea0cwE/S6IFQR7g0IoRiQiRkAIDyA/view?utm_content=DAF6uea0cwE&utm_campaign=designshare&utm_medium=link&utm_source=viewer] ---------------------------------------- Hosted on Acast. See acast.com/privacy [https://acast.com/privacy] for more information.