My Weird Prompts

The Atopic March: Why It Stays on the Skin-Lung-Nose Track

29 min · Gisteren
aflevering The Atopic March: Why It Stays on the Skin-Lung-Nose Track artwork

Beschrijving

The atopic march—eczema to asthma to allergies—seems like a predictable path, but why doesn’t it ever lead to rheumatoid arthritis or lupus? This episode unpacks the immune system’s two distinct misbehavior modes: type two inflammation (atopy) versus Th1/Th17 pathways (autoimmunity). We explore the "leaky skin" hypothesis, the role of epithelial barriers, and why the march can sometimes reverse direction. Discover how filaggrin mutations, environmental triggers, and age-related barrier changes determine which organ expresses the atopic predisposition. Plus, we examine why drugs like dupilumab work across barrier sites but fail in joints, revealing the biological boundaries between these disease clusters.

Reacties

0

Wees de eerste die een reactie plaatst

Meld je nu aan en word lid van de My Weird Prompts community!

Probeer gratis

Probeer 14 dagen gratis

€ 9,99 / maand na proefperiode. · Elk moment opzegbaar.

  • Podcasts die je alleen op Podimo hoort
  • 20 uur luisterboeken / maand
  • Gratis podcasts

Alle afleveringen

200 afleveringen

aflevering Israel's Nuclear Dilemma After Trump's Iran Deal artwork

Israel's Nuclear Dilemma After Trump's Iran Deal

In this episode, we break down the seismic shift from joint US-Israel military action against Iran to Trump announcing a nuclear deal that reportedly caught Netanyahu completely off guard. Israeli officials are telling reporters they've been "screwed" — but publicly Netanyahu insists everything is fine. We examine the terms of the MOU, the gap between US and Iranian versions, and the three impossible choices facing Jerusalem: accept a deal that locks in Iranian nuclear latency, strike unilaterally and risk a catastrophic rupture with Washington, or try to extract private assurances from Trump that may not outlast his presidency. With Defense Minister Katz already ordering the IDF to prepare for independent action, this is the story of an ally that may have concluded its patron is no longer acting in its interests.

Gisteren26 min