Sounds of Science

Join Charles River experts Sandy Kimber, Charlotte Cumper, and Claire Richards from our Portishead site for a discussion on what makes some viruses more contagious than others, how viruses can trick your immune system, and how vaccines can affect viral spread.

When Luke Rosen's daughter was diagnosed with KIF1A—a rare, progressive neurological disorder—he didn't wait for answers. He and his wife built a community, launched a nonprofit, and became a driving force in rare disease research. In this episode, Luke shares how patient-led science accelerates treatments and reshapes what’s possible for families like his.  Show Notes   Sounds of Science - N=1 Episode [https://www.criver.com/eureka/e86-taking-customized-and-collaborative-approach-therapeutic-development] Charles River | Rare Disease [https://www.criver.com/therapeutic-area/rare-disease]  Charles River | Rare Disease for Drug Discovery [https://www.criver.com/products-services/discovery-services/pharmacology-studies/rare-disease-studies?region=3601]  Charles River | ASO Screening Services [https://www.criver.com/products-services/discovery-services/screening-and-profiling-assays/high-throughput-screening/antisense-olignonucleotide-screening?region=3601] Personalized ASO Provides Improvement for a Girl with KAND< an Ultra-rare Disease [https://www.oligotherapeutics.org/personalized-aso-provides-improvements-for-a-girl-with-kand-an-ultra-rare-disease/]  SCA3: A Family Affair [https://www.criver.com/insights/vital-science-podcast/s4-e09-sca3-family-affair]  Susannah's Superhero Story [https://www.kif1a.org/blog/susannahs-superhero-story/]

Are we on the brink of a major shift in research? In this episode of Sounds of Science, Charles River experts challenge traditional approaches, exploring cutting-edge innovations that enhance animal welfare while driving scientific breakthroughs.     From revolutionary non-animal testing methods to advanced behavioral management strategies, we uncover how ethical care leads to better data and faster drug discovery. Tune in to discover how science, compassion, and innovation are shaping the next era of drug development. Show Notes  Animals in Research | 3Rs [https://www.criver.com/about-us/about-us-overview/animals-research?region=3601]  Alternative Methods Advancement Project [https://www.criver.com/about-us/about-us-overview/alternative-methods-advancement-project?region=3601]  CHARTER Program for Lab Animal Welfare [https://www.criver.com/about-us/about-us-overview/animals-research/charter-program?region=3601]  Advancing Responsible Science [https://www.criver.com/about-us/about-us-overview/animals-research/our-4rs-mission]

Did you know that the first attempt at a cancer vaccine was all the way back in the 1800s? I am joined by Charles River experts Louise Brackenbury, Dan Rocca, and Mike Templin to discuss the fascinating science behind therapeutic cancer vaccines. Clarification: Coley’s Toxin is not a vaccine in the traditional sense, but a compound developed by William Coley in the 19th century as a treatment for cancer, and is considered a precursor to modern cancer immunotherapy.

Spheroids are three dimensional cell models that can mimic some organs, tumors, and other biological systems for drug testing. Like organoids and organs-on-a-chip, spheroids are breaking in to drug development as a promising alternative to animal models. I am joined by Madhu Lal Nag, MBS PhD from the 3D in vitro model company InSphero, to discuss the development and future potential of these tiny cellular machines.