Our Enemy’s Enemy: Can Phages Beat Antibacterial Resistance?

At-Home Relief: Novel Drug Empowering Patients in Sickle Cell Crisis

Over 90% of American sickle cell disease (SCD) patients are Black or African American, contributing to a history of underfunding and stigma. Patients in debilitating pain are misconstrued as drug seekers. What medicines they receive have side effects and fail to address the root cause. In this season’s finale, I interview John Paderi, Chief Scientific Officer at IHP Therapeutics. Inspired by Biodesign’s patient-centric approach, he is developing a novel, self-administered drug for SCD pain crisis. Join us to discover the SCD patient journey, shortcomings of existing therapies, and his learnings as CSO—risks, opportunities, strategy and all. We also explore how he integrates Biodesign with his academic training, surprising parallels between SCD and migraines, and his most rewarding moment at IHP so far! References: Overview on Sickle Cell Pain Management (Osunkwo et al.) [https://ashpublications.org/hematology/article/2020/1/562/474283/Optimizing-the-management-of-chronic-pain-in] Health Care Disparities in Sickle Cell Disease (Lee et al.) [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832089/] Impact of Opioid Epidemic on Sickle Cell Patients (Sinha et al.) [https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2734070]

Accessible Diagnostics with Paper, Printer and Pencil

Low-cost, rapid, accurate, portable, heat-proof… These are just a few of the many boundary conditions Prof. Suman Chakraborty keeps in mind while designing for low-resource settings. Inspired by the simple arts and crafts we do in primary school, he builds paper-based frugal diagnostics. He explores the deep science in everyday items. Tune in to hear how he invented pencil-drawn electrodes and microfluidic channels you can print in any office! We also discuss the demand-supply gap in point-of-care devices, his recent push towards device-free testing, and his philosophy on keeping curiosity alive by pursuing simplicity of the mind. References: WHO India Health System Review (How Health Expenditures Drive Poverty) [https://apo.who.int/publications/i/item/india-health-system-review] Publication from Chakraborty Lab on Paper-and-Pencil Microfluidics [https://link.springer.com/article/10.1007/s10404-015-1567-3]

Portable, Painless and Privacy-Aware: Breast Imaging For All

“We always love our technology,” Dr. Geetha says. “It’s easy to say - yeah, that false negative? It has to be false.” Today, I speak with the founder of Niramai, a safe, accessible AI-based cancer diagnostic that’s gone beyond buzzwords to create large-scale, global impact. Join us to hear how Dr. Geetha built the world’s largest database of thermal breast images, navigated doctors’ worries of being replaced by A.I., and adapted her product for diverse contexts, to be low-cost for rural screening and low-risk for quick FDA clearance. Along the way, she shares why cancer rates are increasing among young women, how entrepreneurship feels like racing down an empty highway, and the one thing in her daily routine she prizes more than food! References: Feature on Niramai and Breast Cancer Stats in India [https://medium.com/innovate4health/niramai-thermalytix-transforming-early-breast-cancer-detection-in-india-a3b2d651fc98] WHO Global Cancer Burden News Release [https://www.who.int/news/item/01-02-2024-global-cancer-burden-growing--amidst-mounting-need-for-services#:~:text=] Article Linking Breast Cancer, Childbirth, and Breastfeeding [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972148/] Youtube License Codes: YRVETGM2CE9Z5UVW, QX3HA65SLZLJAKWV, UR8BNRLMRASVSRDR

Our Enemy’s Enemy: Can Phages Beat Antibacterial Resistance?

In 2019, antimicrobial resistance (AMR) caused 1.27 million deaths around the world. Antibiotic misuse is making tried and trusted medicines ineffective against resistant superbugs. In this episode, I speak with Prof. Urmi Bajpai, co-Founder of the International Bacteriophage Research Consortium. We dissect how phages work, what we can and cannot engineer in them today, and why global coordination is essential going forward. Via the One Health lens, we explore the impact of climate change on AMR and how our war on bacteria is interconnected across sectors, from agriculture to medicine. Tune in to also catch Prof. Bajpai’s take on a fictional, futuristic phage-printer and her journey creating a Biomedical Science department from scratch! References: R&D Gaps in Phage Therapy [https://www.liebertpub.com/doi/full/10.1089/phage.2023.0045?download=true&journalCode=phage] Forbes Primer on Phage Therapy [https://www.forbes.com/sites/juergeneckhardt/2023/09/13/phage-therapy-to-defeat-superbugs-is-taking-off/?sh=555f7f1e1307] WHO Antimicrobial Resistance Fact Sheet [https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance#:~:text=It%20is%20estimated%20that%20bacterial,development%20of%20drug%2Dresistant%20pathogens] Music License Codes: YHNLRERFHWIXNVJ0, XLV7SAFD5G0EXWND, 6ZMZK5UJG7ZAITZV

Celsi’s Clinical Journey + The Invention Education Model

Studies reveal >65% of babied admitted into Asian and African NICUs are hypothermic. In Part 3 of this series on neonatal health devices for low-resource settings, I speak with Sonia Sosa from the Rice360 Institute for Global Health Technologies. Through bite-sized student projects, they develop tools such as Celsi, a continuous monitor that alerts nurses of unchecked hypothermia. Tune in as Sonia shares clinical insights from Celsi’s creation and journey to FDA 510(k) clearance in 2023. We also explore what ‘low-resource setting’ truly means to her and how the Invention Education model is fostering creativity and entrepreneurship in Malawi and Tanzania! References: Neonatal Hypothermia Prevalence [https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0248838#sec013] WHO Newborn Mortality Fact Sheet [https://www.who.int/news-room/fact-sheets/detail/newborn-mortality] WHO Preterm Birth Fact Sheet [https://www.who.int/news-room/fact-sheets/detail/preterm-birth] Music License Codes: OSIYU3ZJ3NMOEBRB, BFIVSC8JRHFHEIYI, WGPKEPYQKZDP0V7R