Immune

From the 2024 Society for Leukocyte Biology meeting, Cindy and Brianne talk with Darren Lee to discuss his career, how he got interested in immunology of the eye, and how his team visualizes immune responses of the eye in real time with the hope of better understanding autoimmune uveitis. Hosts: Cindy Leifer [https://www.leiferlab.com/] and Brianne Barker [https://bbarkerdrew.com/] Guest: Darren Lee [https://immunobiology.arizona.edu/research/wilson-lab] Subscribe (free): Apple Podcasts [https://podcasts.apple.com/us/podcast/immune/id1305309644], RSS [http://immune.libsyn.com/rss], email [http://eepurl.com/Gcw59] Become a patron [https://www.microbe.tv/contribute] of Immune! Links for this episode * MicrobeTV Discord Server [https://discord.gg/xA4JX7AeeU] * The eye is an immunosuppressive  [https://www.sciencedirect.com/science/article/pii/S0169409X23001849?via%3Dihub]environment (Adv Drug Delivery Rev 2023) * Tregs control autoimmune uveitis [https://www.nature.com/articles/s41598-025-02816-z.epdf?sharing_token=aIL7RLR-40lWq_QGQdW4vtRgN0jAjWel9jnR3ZoTv0NK7zKw1KSUFjKLLE7m_lKNHuvzw2GXe1gBM-_u4B4vJRobDq2XoX28W_mQthME5fw8oNNP0dCo4S-_42a19xhZmtKHux_dGZtORkAFIcw0mrh752Spfk-wXhwMSRizxao%3D] (Sci Rep 2025) * TIGIT, Tregs,  [https://academic.oup.com/jleukbio/article-abstract/116/5/1054/7681601?redirectedFrom=fulltext&login=false]and autoimmune uveitis (J Leuk Biol 2024) * Society for Leukocyte Biology [https://www.leukocytebiology.org/] * Time stamps by Jolene [https://ramseylab.vercel.app/] Ramsey [https://ramseylab.vercel.app/]. Thanks! Music by Tatami [https://www.premiumbeat.com/artist/tatami]. Logo image by Blausen Medical [https://en.wikiversity.org/wiki/File:Blausen_0077_Basophil.png] Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

Vincent and Cindy discuss differences between MPox-specific T cell responses following infection and vaccination, and lymph node macrophage control of memory B cell localization and trafficking that might be important for choosing which arm to get a vaccine. Hosts: Vincent Racaniello [https://en.wikipedia.org/wiki/Vincent_Racaniello] and Cindy Leifer [https://www.vet.cornell.edu/research/cynthia-leifer-phd] Subscribe (free): Apple Podcasts [https://podcasts.apple.com/us/podcast/immune/id1305309644], RSS [http://immune.libsyn.com/rss], email [http://eepurl.com/Gcw59] Become a patron [https://www.microbe.tv/contribute] of Immune! Links for this episode * MicrobeTV Discord Server [https://discord.gg/xA4JX7AeeU] * Different T memory response to MPox [https://www.nature.com/articles/s41467-025-59370-5] infection or vaccination (Nat Comm 2025) * Macrophages direct B cell recall  [https://www.cell.com/cell/fulltext/S0092-8674(25)00407-6]responses after vaccination (Cell 2025) * Time stamps by Jolene [https://ramseylab.vercel.app/] Ramsey [https://ramseylab.vercel.app/]. Thanks! Music by Tatami. Immune logo image by Blausen Medical [https://en.wikiversity.org/wiki/File:Blausen_0077_Basophil.png] Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

From the 2024 Society for Leukocyte Biology meeting, Cindy and Brianne sit down with Justin Wilson to talk about how he got into research and his more recent studies on innate immune sensors and the interaction between the gut microbiome and inflammation related to inflammatory bowel disease and cancer. Hosts: Cindy Leifer [https://www.leiferlab.com/] and Brianne Barker [https://bbarkerdrew.com/] Guest: Justin Wilson [https://immunobiology.arizona.edu/research/wilson-lab] Subscribe (free): Apple Podcasts [https://podcasts.apple.com/us/podcast/immune/id1305309644], RSS [http://immune.libsyn.com/rss], email [http://eepurl.com/Gcw59] Become a patron [https://www.microbe.tv/contribute] of Immune! Links for this episode * MicrobeTV Discord Server [https://discord.gg/xA4JX7AeeU] * Francisella tularensis undermining macrophage [https://pubmed.ncbi.nlm.nih.gov/19703975/] defenses (Infect Immunity) * AIM2 suppressing colon [https://pubmed.ncbi.nlm.nih.gov/26107252/] cancer (Nature Med) * NLRP12 regulates gut microbiota homeostasis [https://pubmed.ncbi.nlm.nih.gov/30212649/] (Cell Host Microbe) * Oral bacteria and carcinogenesis [https://pubmed.ncbi.nlm.nih.gov/38506551/] connection (Microbiol Mol Bio Rev) * Society for Leukocyte Biology [https://www.leukocytebiology.org/] * Time stamps by Jolene [https://ramseylab.vercel.app/] Ramsey [https://ramseylab.vercel.app/]. Thanks! Music by Tatami [https://www.premiumbeat.com/artist/tatami]. Logo image by Blausen Medical [https://en.wikiversity.org/wiki/File:Blausen_0077_Basophil.png] Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

Steph talks about identification of gut bacteria that can digest protective mucosal antibodies and Vincent covers a new paper on Zika virus that implicates fetal phagocytes in brain invasion, which may provide insight into the devastating microcephaly outcome of infection during pregnancy. Hosts: Vincent Racaniello [https://en.wikipedia.org/wiki/Vincent_Racaniello], Cindy Leifer [https://www.vet.cornell.edu/research/cynthia-leifer-phd], Steph Langel [https://case.edu/medicine/pathology/faculty/stephanie-langel], and Brianne Barker [https://twitter.com/bioprofbarker] Subscribe (free): Apple Podcasts [https://podcasts.apple.com/us/podcast/immune/id1305309644], RSS [http://immune.libsyn.com/rss], email [http://eepurl.com/Gcw59] Become a patron [https://www.microbe.tv/contribute] of Immune! Links for this episode * MicrobeTV Discord Server [https://discord.gg/xA4JX7AeeU] * Gut bacteria induce mucosal immunodeficiency [https://pubmed.ncbi.nlm.nih.gov/39325906/] (Science) * Contribution of fetal mononuclear phagocytes to Zika virus neuroinvasion [https://www.cell.com/cell/abstract/S0092-8674(24)01210-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867424012108%3Fshowall%3Dtrue] (Cell) * TWiV468 [https://www.microbe.tv/twiv/twiv-468/] discusses Zika and brain slice infection model. * Time stamps by Jolene [https://ramseylab.vercel.app/] Ramsey [https://ramseylab.vercel.app/]. Thanks! Music by Tatami. Immune logo image by Blausen Medical [https://en.wikiversity.org/wiki/File:Blausen_0077_Basophil.png] Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

From the 2024 Society for Leukocyte Biology meeting, Immune talks with Holger Heine about the discovery of immune recognition of bacterial lipopolysaccharide and innate immunity to organisms within the kingdom Archaea. Hosts: Cindy Leifer [https://www.leiferlab.com/] and Brianne Barker [https://bbarkerdrew.com/] Guest: Holger Heine [https://fz-borstel.de/en/research-at-the-fzb/chronic-lung-diseases/innate-immunity] Become a patron [https://www.microbe.tv/contribute] of Immune! Links for this episode * MicrobeTV Discord Server [https://discord.gg/xA4JX7AeeU] * TLR8 recognizes human gut-associated archaeon [https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01535/full] (Front Immunol) * The human archaeome and its relevance [https://pubmed.ncbi.nlm.nih.gov/38555566/] for health and disease (FEBS) * Structural insights into TLR4 recognition of synthetic LPS [https://www.nature.com/articles/s41467-025-59550-3] mimetics (Nature Comm) * Society for Leukocyte Biology [https://www.leukocytebiology.org/] * Time stamps by Jolene [https://ramseylab.vercel.app/] Ramsey [https://ramseylab.vercel.app/]. Thanks! Music by Tatami [https://www.premiumbeat.com/artist/tatami]. Logo image by Blausen Medical [https://en.wikiversity.org/wiki/File:Blausen_0077_Basophil.png] Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.