Pearls and Prep

Auvelity May Change How You Think About Depression: NMDA, Sigma-1, Dopamine & Clinical Pearls

23 min · 28. maj 2026
episode Auvelity May Change How You Think About Depression: NMDA, Sigma-1, Dopamine & Clinical Pearls cover

Description

There are two kinds of clinicians—the ones who follow algorithms, and the ones who understand the “why.” Patients know the difference. Know the WHY! Join our clinical library today on PATREON! 👉 https://www.patreon.com/PearlsandPrep [https://www.patreon.com/PearlsandPrep] We're diving into the nitty-gritty of a super cool antidepressant called Auvelity today. This bad boy is one of the first fresh faces in the antidepressant world in over 30 years, and it’s not just your run-of-the-mill serotonin booster. We're talking NMDA antagonism and sigma 1 receptor agonism—yeah, that’s some fancy science! We'll chat about a case study featuring Sarah, a marketing manager who's had it up to here with the usual meds that leave her feeling like a zombie. So, grab your headphones and let's unpack how Auvelity could be a game changer for folks who need a quicker fix without the cringe side effects. It’s all about finding that sweet spot where patients can actually feel better and get back to living their lives! 32 Auvelity May Change How You Think About Depression: NMDA, Sigma-1, Dopamine & Clinical Pearls Pearls and Prep pearlsandprep@mail.com https://patreon.com/PearlsandPrep?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLink Takeaways: * Auvelity is a brand-new antidepressant that works differently from traditional meds, which is super cool. * Patients often want immediate relief, and Auvelity can kick in faster than your average SSRI. * The way Auvelity combines dextromethorphan and Wellbutrin is a game changer in treating depression. * Understanding how a medication works is crucial for clinicians to explain it clearly to patients. * This podcast really highlights the real-world challenges of prescribing meds in a busy practice setting. * Not all antidepressants are one-size-fits-all, and we need to be flexible with treatment options for patients. Companies mentioned in this episode: * Zoloft * Remeron * Effexor * Cymbalta * Wellbutrin * Auvelity * Esketamine * TMS * Luvox * Paxil * Prozac This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy

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95 episodes

episode Mock Patient Elias: “Am I Real?” | The Diagnostic Tangle of Depersonalization vs Panic vs PTSD artwork

Mock Patient Elias: “Am I Real?” | The Diagnostic Tangle of Depersonalization vs Panic vs PTSD

There are two kinds of clinicians—the ones who follow algorithms, and the ones who understand the “why.” Be the second on Patreon: 👉 https://www.patreon.com/PearlsandPrep [https://www.patreon.com/PearlsandPrep] Today we're diving into a real head-scratcher with our mock patient, Elias. This dude is feeling like he’s living life behind glass—everything's distant and unreal for months now, and he’s convinced he’s losing it. We’ll explore the nitty-gritty of his symptoms, which include feeling like an automaton and questioning if he’s actually here. Trust me, we’re peeling back the layers on this one, and it’s not just your everyday anxiety or depression we’re dealing with. So, if you’re ready to level up your understanding of these bizarre perceptual disturbances and get equipped for the real world, stick around! 27 Mock Patient Elias: “Am I Real?” | The Diagnostic Tangle of Depersonalization vs Panic vs PTSD Pearls and Prep pearlsandprep@mail.com https://patreon.com/PearlsandPrep?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLink Elias, a 22-year-old grad student, brings a real head-scratcher to the table as he shares his struggle with feeling detached from reality. Picture this: he’s living life like he’s watching it through a window, where nothing feels genuine—his own hands look foreign, and conversations sound scripted. This episode takes us deep into the world of depersonalization and derealization, a realm where anxiety meets bizarre perceptual distortions. We dive into the clinical aspects of Elias's experience, discussing his past with high-potency cannabis, a panic attack that kicked off this whirlwind, and how his family history plays into his current predicament. Elias is not just anxious; he’s terrified, spending hours Googling his symptoms and avoiding crowded places—classic signs of someone grappling with intense anxiety. As we break down Elias’s case, we get into the nitty-gritty of mental status exams. His ability to articulate his feelings and maintain awareness of his reality sets the stage for a fascinating discussion on treatment options. We explore the potential of cognitive-behavioral therapy (CBT) as a means to tackle the distorted perceptions plaguing Elias, while also considering the role of SSRIs in managing his anxiety. The episode emphasizes the need to differentiate between panic disorder and depersonalization disorder, with a playful banter that keeps things light while we sift through serious topics. By the end, we find ourselves not just pondering Elias’s situation but also armed with insights that can help us in our own practices, ready to tackle cases that might seem out of the ordinary, but are definitely not rare. What’s particularly striking here is the exploration of how early emotional experiences shape our current mental states. The discussion flows smoothly from clinical observations to practical advice, reminding us that our patients are nuanced beings with rich histories that influence their present. So, whether you’re a seasoned clinician or a curious listener, this episode will leave you with pearls of wisdom to prep you for practice, ensuring that next time a patient like Elias walks through your door, you’ll be ready to help them navigate their unique journey back to feeling real again. Takeaways: * Elias, our mock patient, feels like he's watching life through a window—super unsettling, right? * Despite his symptoms, Elias knows he's real and the world's real, which is a major win for us. * His intense anxiety leads him to Google symptoms, fearing he has something serious like schizophrenia. * We gotta remember, if patients are aware of their distress, we can steer clear of psychotic disorders. * Understanding the difference between panic and depersonalization can really help in diagnosing these cases. * CBT is the gold standard for treating depersonalization disorder—let's get those sessions rolling! This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy

23. juni 202631 min
episode Kratom Uncovered: 5 Game-Changing Pearls for Your Practice artwork

Kratom Uncovered: 5 Game-Changing Pearls for Your Practice

There are two kinds of clinicians—the ones who follow algorithms, and the ones who understand the “why.” Patients know the difference. Know the WHY! Join our clinical library today on PATREON! 👉 https://www.patreon.com/PearlsandPrep [https://www.patreon.com/PearlsandPrep] Today, we’re diving into the wild world of Kratom, and trust me, it’s a topic that’s got some serious implications for us as psychiatric providers. I’ve gathered five key pearls from clinical research that’ll totally change how you view this substance. It’s not just a trendy herbal tea; this stuff can act like a partial opioid agonist and is often misunderstood by patients who think it’s harmless. We're also gonna chat about how it’s marketed and how that affects what our patients tell us—or don’t tell us—about their use. So grab your favorite drink, kick back, and let’s break down why asking the right questions about Kratom is crucial for patient care and safety! Kratom has been a hot topic lately, and in this chat, we dive deep into its world. It's not just some herbal tea; it’s a complex little leaf that’s causing quite the stir in the psychiatric realm. We bust out five pearls that’ll have you rethinking everything you thought you knew about this substance. From its origins in Southeast Asia to its new life in gas stations across America, we explore how the cultural context of Kratom changes its perceived safety. With its partial opioid agonist properties, Kratom can act like both a stimulant and an opioid, which makes it a bit of a chameleon in the world of substances. But beware, what’s sold as a harmless energy booster can have lethal consequences when mixed with other medications. It’s crucial for us, as practitioners, to be aware of Kratom’s widespread popularity and the misconceptions surrounding its use. If we’re not asking the right questions, we might miss out on critical information that could change our patients’ treatment plans. So let’s get into the nitty-gritty of Kratom, from its pharmacological effects to the potential withdrawal symptoms that can mimic serious psychiatric disorders. We’re here to equip ourselves with knowledge that can save lives! Takeaways: * Kratom's effects are not what they seem; it's marketed as a harmless supplement, but can be lethal when mixed with other substances. * Understanding the pharmacology behind Kratom is crucial; it behaves like both a stimulant and an opioid depending on the dose. * Kratom can be invisible in drug screenings, leading to misdiagnoses and inadequate treatment for patients using it. * It's super important to ask patients about Kratom specifically, as it can influence their treatment and outcomes. * Kratom withdrawal can mimic serious psychiatric emergencies, which can confuse diagnosis and lead to dangerous treatment decisions. * Kratom is everywhere and cheap, so be mindful of its implications on patient care and medication interactions. Links referenced in this episode: * patreon.com/pearlsandprep [https://patreon.com/pearlsandprep] Companies mentioned in this episode: * Kratom * Thailand * Malaysia * Indonesia * Papua New Guinea * FDA * Abilify * Risperdal * Paxil * Prozac * Effexor * Motrin * Seroquel * Remeron * Suboxone * Quest * LabCorp This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy

19. juni 202623 min
episode Memorizing ADHD Inattentive Type Criteria Through a Cookie Baking Story artwork

Memorizing ADHD Inattentive Type Criteria Through a Cookie Baking Story

There are two kinds of clinicians—the ones who follow algorithms, and the ones who understand the “why.” Be the second on Patreon: 👉 https://www.patreon.com/PearlsandPrep [https://www.patreon.com/PearlsandPrep] In this episode of Pearls and Prep, we meet Milo, a sweet but scatterbrained baker whose cookie chaos becomes the perfect metaphor for inattentive ADHD. Through Milo’s messy kitchen adventures, listeners will learn — and never forget — the nine official DSM-5-TR symptoms of the inattentive subtype of ADHD, from forgetfulness and distractibility to careless mistakes and mental drift. This episode turns psychiatric education into storytelling — blending humor, empathy, and clinical accuracy to make complex criteria easy to remember. Perfect for psychiatric NPs, PA students, med students, residents, therapists, and clinicians looking to solidify their ADHD diagnostic mastery in a fun, sticky way. We’ll explore: 🍪 How Milo’s burnt cookies mirror difficulty sustaining attention. 🧁 Why his unfinished recipes reveal poor follow-through on tasks. 🍰 And how his sugar-sprinkled daydreams teach distractibility and forgetfulness. Whether you’re studying for boards or teaching ADHD to your own patients, this 10-minute story will help the inattentive criteria finally “click” — one cookie crumb at a time. This episode meticulously elucidates the intricacies of diagnosing Attention Deficit Hyperactivity Disorder (ADHD), specifically the inattentive type, through a compelling narrative framework. We present a concise tale featuring a character named Milo, a nine-year-old boy whose experiences embody the nine core symptoms requisite for an ADHD diagnosis. By weaving these symptoms into a relatable story, we aim to enhance the listener's ability to recall and apply the diagnostic criteria effectively during patient evaluations. The narrative not only encapsulates the particularities of inattentive ADHD but also emphasizes the significance of understanding these components within varied contexts. Ultimately, our goal is to equip practitioners with a more nuanced and accessible approach to diagnosing ADHD, thereby fostering greater diagnostic precision and patient care. 23 Memorizing ADHD Inattentive Type Criteria Through a Cookie Baking Story Pearls and Prep pearlsandprep@mail.com https://patreon.com/PearlsandPrep?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLink The episode presents a comprehensive exploration of ADHD inattentive type diagnosis through a creative narrative featuring Milo, a nine-year-old boy engaged in a baking endeavor for his Valentine. This approach uniquely illustrates the nine diagnostic criteria outlined in the DSM, as Milo's baking misadventures encapsulate each symptom. I recount how Milo's procrastination, careless errors, disorganization, and poor time management vividly reflect the challenges faced by individuals with ADHD. This engaging storytelling format serves as an effective mnemonic device, making the diagnostic criteria more accessible and memorable for practitioners. Throughout the discussion, I emphasize the importance of integrating narrative techniques into clinical practice. By utilizing a relatable character like Milo, I aim to enhance the listener's understanding of ADHD symptoms and facilitate a more effective diagnostic process. This storytelling method not only aids in retention but also allows clinicians to approach patient interactions with a nuanced understanding of the complexities of ADHD. By recalling Milo's experiences, practitioners can more easily remember the specific questions to ask during evaluations and the symptoms to observe in their patients. Moreover, I caution that while this narrative approach is beneficial, it should complement rather than replace traditional diagnostic methods. Rigorous assessment tools and structured interviews remain vital for accurate diagnosis. However, the episode ultimately highlights the potential of storytelling as a transformative tool in the clinician's toolkit, encouraging listeners to adopt innovative strategies in their practice to improve patient outcomes and enhance their diagnostic skills. Takeaways: * The podcast episode provides an innovative approach for memorizing DSM diagnoses through storytelling techniques. * A case study of a nine-year-old named Milo illustrates the nine symptoms of ADHD inattentive type. * Listeners are encouraged to utilize visual narratives to enhance their understanding of clinical symptoms. * The importance of structured interviews and diagnostic tools is emphasized alongside the storytelling method. This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy

16. juni 202613 min
episode The DSM Sleep Disorders: One Episode to Make Sense Them All. artwork

The DSM Sleep Disorders: One Episode to Make Sense Them All.

There are two kinds of clinicians—the ones who follow algorithms, and the ones who understand the “why.” Patients know the difference. Know the WHY! Join our clinical library today on PATREON! 👉 https://www.patreon.com/PearlsandPrep [https://www.patreon.com/PearlsandPrep] **10 Sleep Disorder Categories?! Don't Worry—We've Got This.** Today we're tackling one of the most intimidating chapters in the DSM-5-TR: Sleep-Wake Disorders. At first glance, the DSM throws ten categories of sleep disorders at you, from insomnia and hypersomnolence to narcolepsy, sleep apnea, nightmares, sleep terrors, sleepwalking, REM sleep behavior disorder, restless legs syndrome, and more. It can feel overwhelming fast. In this episode, we'll simplify the entire chapter into an easy-to-remember framework so you can recognize common sleep disorders, understand key diagnostic differences, know when a sleep study is indicated, and avoid common exam and clinical pitfalls. Whether you're a PMHNP student, psychiatric nurse practitioner, psychiatry resident, therapist, or practicing clinician, this episode will help you organize the sleep disorders chapter into a system that actually makes sense. **Key Topics Covered:** • DSM-5-TR Sleep-Wake Disorders overview • Insomnia Disorder • Hypersomnolence Disorder • Narcolepsy • Obstructive Sleep Apnea vs Central Sleep Apnea • Circadian Rhythm Sleep-Wake Disorders • Nightmare Disorder • Sleep Terrors and Confusional Arousals • Sleepwalking (Somnambulism) • REM Sleep Behavior Disorder • Restless Legs Syndrome • Sleep Paralysis • When to order polysomnography (sleep studies) • High-yield board exam and clinical pearls **Takeaways:** ✓ Learn all 10 DSM-5-TR sleep disorder categories without memorizing endless criteria ✓ Understand the difference between REM and NREM parasomnias ✓ Know when sleep studies are indicated ✓ Recognize common board-style diagnostic traps ✓ Build a practical framework for clinical practice 🎙️ Pearls & Prep: Psychiatric Case Studies Join the Boss Pearl community for premium episodes, visual psychiatry pearls, study guides, cheat sheets, and bonus content: patreon.com/pearlsandprep #SleepDisorders #DSM5TR #Psychiatry #PMHNP #PsychNP #PsychiatricNursePractitioner #MentalHealth #Narcolepsy #Insomnia #SleepApnea #Parasomnias #PsychiatryPodcast #NursePractitioner #PsychiatricMentalHealthNursePractitioner #PsychBoardPrep 32 The DSM Sleep Disorders: One Episode to Make Sense Them All. Pearls and Prep pearlsandprep@mail.com https://patreon.com/PearlsandPrep?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLink This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy

15. juni 202637 min
episode 5 Things You Probably Get Wrong About Adjustment Disorder artwork

5 Things You Probably Get Wrong About Adjustment Disorder

There are two kinds of clinicians—the ones who follow algorithms, and the ones who understand the “why.” Patients know the difference. Know the WHY! Join our clinical library today on PATREON! 👉 https://www.patreon.com/PearlsandPrep [https://www.patreon.com/PearlsandPrep] Today, we're diving into the nitty-gritty of adjustment disorder, and trust me, you don’t want to miss this! We're breaking down five things you probably didn’t know about this diagnosis that often gets a bad rap for being "mild." Spoiler alert: it’s not as chill as it sounds and can definitely pack a punch if you're not careful. I’ll share my own experiences and insights from the front lines, highlighting why accurate diagnosis matters and how common mislabeling can lead to some serious treatment mix-ups. So grab your favorite drink, kick back, and let’s unravel the complexities of adjustment disorder together! 32 5 Things You Probably Get Wrong About Adjustment Disorder Pearls and Prep pearlsandprep@mail.com https://patreon.com/PearlsandPrep?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLink Adjustment disorders might sound like a walk in the park, but let me tell you, they're more like a rollercoaster ride without a safety harness. We're diving deep into the nitty-gritty of these disorders, and boy, do we have some eye-openers for you! First off, don't let the DSM-5 fool you—adjustment disorder is often misdiagnosed as PTSD. It’s like calling a kitten a lion just because it’s furry! We chat about how crucial it is to get this right because the treatment paths are as different as night and day. You’ll hear about the importance of resolving the actual stressor at play, and how sometimes, all you need is a good ol’ CBT session instead of pills—because who needs meds when you can just work through your stuff? Plus, we sprinkle in some personal stories from the trenches of practice that bring the topic to life. So stick around, because we’re about to unravel five pearls of wisdom about adjustment disorders that could seriously change your practice game. Takeaways: * Adjustment disorder can be tricky to diagnose and is often misidentified as PTSD, so let's be cautious. * Medications don't usually cut it for adjustment disorder; CBT and resolving the stressor are key. * Be on the lookout for personality disorders in patients with adjustment disorders—they often go hand in hand. * Suicide risk is significantly higher in people with adjustment disorders, so we need to screen carefully. * Adjustment disorders have several types, including mixed emotions and conduct disturbances, so keep that in mind. * Always remember that adjustment disorders can evolve into more serious conditions like MDD or PTSD over time. Links referenced in this episode: * patreon.com/pearlsandprep [https://patreon.com/pearlsandprep] This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy

14. juni 202624 min