Premier Cardiovascular Health and Performance Podcast

#45: Gender Differences in Fat Distribution and Weight Loss

50 min · 19. mar. 2026
episode #45: Gender Differences in Fat Distribution and Weight Loss cover

Description

Most people think fat is passive — something to lose, shrink, or eliminate. Dr. Deborah Clegg explains why that mindset is incomplete. Fat is an active endocrine organ. It produces hormones, regulates metabolism, and directly influences disease risk. * Why fat distribution matters more than total fat * The critical difference between visceral and subcutaneous fat * How estrogen protects metabolic health — and what happens after menopause * Why women lose weight differently than men * The role of brown, white, and beige fat in energy balance * How evolution shaped the way our bodies store fat This episode challenges the idea that all fat is bad — and reframes it as something to understand, not just fight. — This episode is sponsored by Lightstone DIRECT. [https://lightstonedirect.com/dpn] Lightstone DIRECT invites you to partner with a $12B AUM real estate institution as you grow your portfolio. Access the same single-asset multifamily and industrial deals Lightstone pursues with its own capital – Lightstone co-invests a minimum of 20% in each deal alongside individual investors like you. You’re an institution. Time to invest like one. What You’ll Learn * The difference between visceral fat (harmful) and subcutaneous fat (protective) * How estrogen improves metabolic health and fat function * Why women are protected from metabolic disease before menopause * What actually happens to body composition after menopause * Why weight loss is biologically harder for women * The role of inflammation in unhealthy fat storage * How brown and beige fat increase calorie burning Key Takeaway Not all fat is bad. Where you store it, how it functions, and how your hormones regulate it matter far more than the number on the scale.   GUEST BIO Dr. Deborah J. Clegg is a leading researcher in metabolism, obesity, and cardiometabolic health, with a focus on how sex hormones influence energy balance and fat distribution. She serves as Vice President for Research at Texas Tech University Health Sciences Center El Paso and has authored more than 150 peer-reviewed publications across nutrition, endocrinology, and metabolic disease. Originally trained as a dietitian, Dr. Clegg earned her PhD in Nutrition from the University of Georgia, an MBA from Boston University, and completed postdoctoral training in obesity research at the University of Cincinnati. Her work bridges basic science and clinical insight to better understand — and improve — how we prevent and treat metabolic disease.   Resources & Links Texas Tech Health Sciences Center (Faculty Page): https://www.cardiometabolichealth.org/faculty/deborah-j-clegg-phd-mba/ [https://www.cardiometabolichealth.org/faculty/deborah-j-clegg-phd-mba/] Research & Publications: Search: Deborah Clegg metabolism research (150+ publications) Referenced Concepts in Episode: * Visceral vs subcutaneous fat * Estrogen and metabolic protection * Brown & beige fat metabolism * Hormone replacement therapy (HRT) timing   Episodes Referenced In This Show #17: From Couch to Everest: Dr. Biff Palmer Discusses His Unlikely Journey to the Top of the World [https://premier-cardiovascular-health-and-performance-podcast.simplecast.com/episodes/17-from-couch-to-everest-dr-biff-palmer-discusses-his-unlikely-journey-to-the-top-of-the-world] #22: Why Weight Loss Stalls—Discussing the Role of Hormones, Metabolic Health, and GLP-1 Mimetics with Dr. Marguerite Weston [https://premier-cardiovascular-health-and-performance-podcast.simplecast.com/episodes/22-why-weight-loss-stallsdiscussing-the-role-of-hormones-metabolic-health-and-glp-1-mimetics-with-dr-marguerite-weston]   LET’S CONNECT: Work with Dr. Chris Huff: Premier Cardiovascular Health [https://www.premiercardiohealth.com/] Facebook: https://www.facebook.com/chris.huff.9480 [https://www.facebook.com/chris.huff.9480] Instagram: @hufcm [https://www.instagram.com/hufcm] Disclaimer: The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before making any decisions about your health or medical treatment.

Comments

0

Be the first to comment

Sign up now and become a member of the Premier Cardiovascular Health and Performance Podcast community!

Get Started

1 month for 9 kr.

Then 99 kr. / month · Cancel anytime.

  • Podcasts kun på Podimo
  • 20 lydbogstimer pr. måned
  • Gratis podcasts

All episodes

50 episodes

episode #49: How to Survive and Thrive During a Hospital Stay: A Guide to Safer Hospital Care artwork

#49: How to Survive and Thrive During a Hospital Stay: A Guide to Safer Hospital Care

Most people assume that once they enter a hospital, every aspect of their care will be managed perfectly. But hospitals are complex environments filled with busy teams, multiple providers, changing shifts, and countless decisions being made every day. Dr. Chris Huff explains why patients and families should take an active role in their care — not out of fear, but out of awareness. Drawing from his experience as an interventional cardiologist trained at elite institutions, Dr. Huff discusses real examples of preventable hospital complications and shares practical strategies to improve communication, reduce errors, and help patients recover more quickly. Topics include: * Why hospitalization carries risks — even at excellent medical centers * The importance of telling your story clearly * Why teaching hospitals can often provide additional advantages * How to know when a transfer to a higher level of care is appropriate * Why being respectful and engaged can positively impact your hospital experience * The importance of understanding every test, medication, and procedure before agreeing to it * How sleep, nutrition, and mobility affect your recovery * What questions to ask before leaving the hospital This episode is a practical roadmap for patients and families who want to confidently navigate one of life’s most stressful experiences. WHAT YOU’LL LEARN * How to become your own best healthcare advocate * Why medication errors are one of the most common preventable causes of harm in hospitals * Why you should always understand every medication before taking it * How to communicate effectively with doctors, nurses, residents, and specialists * The benefits and misconceptions surrounding teaching hospitals * Why unnecessary fasting, blood draws, and overnight interruptions may slow recovery * How movement and physical therapy can improve your chances of going home sooner * The critical steps to take before discharge, including reviewing medications and follow-up plans * How family members can advocate effectively without creating barriers to care KEY TAKEAWAY The best healthcare outcomes happen when patients and medical teams work together. Ask questions. Understand your treatment. Stay engaged in your care. Being an informed, respectful advocate for yourself or a loved one may be one of the most powerful tools for achieving excellent hospital care. LET’S CONNECT: * Work with Dr. Chris Huff: Premier Cardiovascular Health [https://premiercardiovascularhealth.com] * Facebook: https://www.facebook.com/chris.huff.9480 [https://www.facebook.com/chris.huff.9480] * Instagram: @hufcm REFERENCED CONCEPTS IN EPISODE * Preventable hospital errors and patient safety * Teaching hospitals vs. community hospitals * Medication safety and understanding your prescriptions * The importance of asking questions and knowing your plan of care * Hospital discharge planning and follow-up * Mobility, nutrition, and sleep as key components of recovery * Being an effective advocate for yourself and your loved ones Disclaimer: The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before making any decisions about your health or medical treatment.

21. juni 202640 min
episode #48: Mental Fortitude, Discipline, and the Systems That Drive High Performance artwork

#48: Mental Fortitude, Discipline, and the Systems That Drive High Performance

Most people think performance comes down to motivation, talent, or willpower. Dre Baldwin explains why that thinking is incomplete. Discipline is a byproduct of structure, not a personality trait. It’s what shows up when motivation doesn’t, and it's what separates the people who talk about high performance from the people who actually deliver. * Why motivation fails and discipline finishes the race * How structure produces discipline, and discipline produces confidence * Why accountability matters more than effort or willpower * The “Third Day” principle that separates pros from amateurs * Why talented people fall short — and what the AWOL effect really means * How to come back from setbacks without starting from zero This episode reframes performance as something you build with systems — not something you wait to feel. — WHAT YOU’LL LEARN * The difference between motivation and discipline * Why structure (not feelings) creates consistent performance * How to find and work with an accountability partner who actually holds the line * The hierarchy of principle → structure → discipline → confidence * What the “Third Day” and “Fourth Day” mean for sticking with a process * How to get back on track after falling off without starting over * Why the AWOL effect (Ability Without Output Leverage) sinks talented people * How to remove internal negotiation from your daily operating system KEY TAKEAWAY Discipline isn’t a personality trait. It’s the byproduct of a structure you follow consistently — and once that structure is in place, performance stops depending on how you feel. GUEST BIO Dre Baldwin is the founder of Work On Your Game®, a system used by entrepreneurs, executives, athletes, and high performers to install discipline, decision-making structure, and execution reliability. Before becoming a speaker, author, and business leader, Dre built a professional basketball career the unconventional way — starting at the Division III level with no major recruiting attention and earning his opportunities through consistency, repetition, and mental discipline. That same mindset evolved into the Work On Your Game® philosophy that now reaches millions of people around the world. Today, Dre works with executives, athletes, entrepreneurs, and organizations on leadership, mindset, decision-making, and execution. He is a 4-time TEDx speaker, the author of 43 books, and the host of the Work On Your Game podcast, where he breaks down the habits and mental frameworks behind sustained high performance. RESOURCES & LINKS * Power Presence Protocol: https://powerpresenceprotocol.com [https://powerpresenceprotocol.com] * Work On Your Game: https://www.dreallday.com [https://www.dreallday.com] * Books by Dre Baldwin (43 titles): * Search: Dre Baldwin author (Work On Your Game, The Third Day, The Mental Workbook, and more) CONNECT WITH DRE BALDWIN * Work On Your Game [https://www.workonyourgame.com/] * YouTube Channel [https://www.youtube.com/@DreAllDay] * Instagram [https://www.instagram.com/drebaldwin] * LinkedIn [https://www.linkedin.com/in/dreallday] * Work On Your Game Podcast [https://www.workonyourgamepodcast.com/] REFERENCED CONCEPTS IN EPISODE: * Discipline vs. motivation * The Third Day & Fourth Day framework * AWOL effect (Ability Without Output Leverage) * Principle → Structure → Discipline hierarchy * Removing internal negotiation LET’S CONNECT: Work with Dr. Chris Huff: Premier Cardiovascular Health [https://premiercardiovascularhealth.com] Facebook: https://www.facebook.com/chris.huff.9480 [https://www.facebook.com/chris.huff.9480] Instagram: @hufcm Disclaimer: The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before making any decisions about your health or medical treatment.

22. maj 202651 min
episode #47: Peptides artwork

#47: Peptides

A century of data, some of the most important drugs in modern medicine, and a Wild West of unregulated products being sold online with claims that outrun the evidence. That’s the peptide world right now. Part of the confusion is that the word "peptide" gets used for everything from injectable insulin — one of the most consequential discoveries in the history of medicine — to vials of powder shipped from overseas with no oversight at all. In this episode, Dr. Chris Huff pulls the curtain back. He walks through what a peptide actually is (a short chain of amino acids that acts as a signaling molecule in the body), how the story started in the 1920s with insulin, and how the field exploded with GLP-1 agonists like semaglutide— drugs that are reshaping how we think about diabetes, obesity, and even cardiovascular risk. He gets into the SELECT trial, the roughly 20% relative risk reduction in major cardiovascular events seen with semaglutide in patients with obesity but not diabetes, and what that finding actually means for the people sitting in his exam room. And he’s just as honest about the other side of the conversation, the wellness side, where peptides like BPC-157, TB-500, CJC-1295, and MOTS-c are marketed for recovery, longevity, and performance. If someone in your life is considering a peptide — for weightloss, injury recovery, or "longevity" — this episode is worth the listen. — This episode is sponsored by Lightstone DIRECT. [https://lightstonedirect.com/dpn] Lightstone DIRECT invites you to partner with a $12B AUM real estate institution as you grow your portfolio. Access the same single-asset multifamily and industrial deals Lightstone pursues with its own capital – Lightstone co-invests a minimum of 20% in each deal alongside individual investors like you. You’re an institution. Time to invest like one. — WHAT YOU’LL LEARN * What a peptide actually is  * How the peptide story started in the 1920s and changed type 1 diabetes from a fatal disease to a manageable one * How GLP-1 drugs work in the body — insulin, glucagon, gastric emptying, and satiety * What the SELECT trial showed about semaglutide and cardiovascular risk in patients without diabetes * The strange but true origin story of GLP-1 medications — and the desert lizard at the center of it * How approved peptides are actually manufactured, and why that’s different from what you’ll find online * Why the FDA has issued warnings about unapproved GLP-1 products * What’s actually known about BPC-157, TB-500, CJC-1295, and MOTS-c — and where the data stops * The real risks of unregulated peptides, including immune reactions and systemic inflammation * The questions to ask before starting any peptide therapy KEY TAKEAWAY Peptides aren’t good or bad. The right question is whether the specific peptide you’re considering has been studied in humans, manufactured to a standard you can trust, and prescribed by someone who knows your full picture. In medicine, that difference is everything. ABOUT THE HOST Dr. Chris Huff is a cardiologist who’s spent his career trying to make heart health less mysterious. He’s treated thousands of patients, prescribed plenty of medications, talked plenty of patients out of starting them, and brought his own LDL from 170 down into the 60s through nutrition alone. That mix of clinical experience and personal experience shows up in everything he does. He’s a believer in the data. He’s also a believer that the patient in front of him is a whole person, not a lab value. LET'S CONNECT Work with Dr. Chris Huff: Premier Cardiovascular Health [https://premiercardiovascularhealth.com] Facebook: facebook.com/chris.huff.9480 [https://www.facebook.com/chris.huff.9480] Instagram: @hufcm Disclaimer: The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before making any decisions about your health or medical treatment.

30. apr. 202610 min
episode #46: The Truth About Statins artwork

#46: The Truth About Statins

Hundreds of thousands of patients. Decades of data. Some of the strongest evidence in modern medicine. And yet — statins are still one of the most argued-about medications out there. Why? Part of it is the internet. Part of it is misunderstanding what these drugs actually do. And part of it is that the conversation almost never matches what really happens in a cardiologist's office. In this episode, Dr. Chris Huff pulls the curtain back. He talks through how statins came to be (the story starts in a Japanese lab in the 1970s, with a researcher studying fungi), how they work inside the body, and why the real target isn't your cholesterol number — it's the number of particles floating around in your bloodstream looking for a place to land. He gets honest about the side effects. What's real, what's overblown, and what to do when a statin genuinely isn't working for you. And he's just as honest about the times he doesn't reach for the prescription pad. Not everyone with elevated cholesterol needs a pill. Sometimes it needs a conversation about food, exercise, and whether you've actually been doing what you said you would. If you've been told to start a statin and you're not sure — or you're already on one and wondering if you should be — this episode is for you. — This episode is sponsored by Lightstone DIRECT. [https://lightstonedirect.com/dpn] Lightstone DIRECT invites you to partner with a $12B AUM real estate institution as you grow your portfolio. Access the same single-asset multifamily and industrial deals Lightstone pursues with its own capital – Lightstone co-invests a minimum of 20% in each deal alongside individual investors like you. You’re an institution. Time to invest like one.   WHAT YOU'LL LEARN * Where statins actually came from  * Why the cholesterol number on your lab report isn't the whole picture * What the data really shows regarding heart attack, stroke, and mortality * Who genuinely needs to be on a statin — and who probably doesn't * Why people walk in convinced their doctor is just trying to push pills (and the truth about how doctors actually get paid) * What to do if your muscles ache after starting one * The alternatives when statins just aren't going to work * How a calcium score and an Lp(a) test can change the whole conversation KEY TAKEAWAY The right answer regarding statin therapy isn't a blanket yes or no. It's a real conversation about your risk, your life, and what you're actually willing to do — and a doctor willing to keep adjusting until it works for you. ABOUT THE HOST Dr. Chris Huff is an interventional cardiologist who's spent his career trying to make heart health less mysterious. He's treated thousands of patients with statins, prescribed plenty, talked plenty out of starting them, and lived the cholesterol journey himself — watching his own LDL climb to 170 in his adulthood and bringing it back down to the 60s through nutrition alone. That mix of clinical experience and personal experience shows up in everything he does. He's a believer in the data. He's also a believer that the patient in front of him is a whole person, not a lab value. EPISODES WORTH GOING BACK TO * The episode on coronary calcium scoring — what it is and why it might change your treatment plan - Episode 42 [https://premier-cardiovascular-health-and-performance-podcast.simplecast.com/episodes/42-abnormal-calcium-scorenow-what] * Episodes on lowering cholesterol through nutrition — including Dr. Huff's own story - episode - Episode 2 [https://premier-cardiovascular-health-and-performance-podcast.simplecast.com/episodes/understanding-your-cholesterol-profile-and-how-it-affects-your-heart-health] * The deep dive on Lp(a) — the test almost no one is getting - Episode 11 [https://premier-cardiovascular-health-and-performance-podcast.simplecast.com/episodes/11-advanced-lipidology-for-cardiovascular-care] LET'S CONNECT Work with Dr. Chris Huff: Premier Cardiovascular Health [https://premiercardiovascularhealth.com] Facebook: facebook.com/chris.huff.9480 [https://www.facebook.com/chris.huff.9480] Instagram: @hufcm Disclaimer: The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before making any decisions about your health or medical treatment.

26. apr. 202632 min
episode #45: Gender Differences in Fat Distribution and Weight Loss artwork

#45: Gender Differences in Fat Distribution and Weight Loss

Most people think fat is passive — something to lose, shrink, or eliminate. Dr. Deborah Clegg explains why that mindset is incomplete. Fat is an active endocrine organ. It produces hormones, regulates metabolism, and directly influences disease risk. * Why fat distribution matters more than total fat * The critical difference between visceral and subcutaneous fat * How estrogen protects metabolic health — and what happens after menopause * Why women lose weight differently than men * The role of brown, white, and beige fat in energy balance * How evolution shaped the way our bodies store fat This episode challenges the idea that all fat is bad — and reframes it as something to understand, not just fight. — This episode is sponsored by Lightstone DIRECT. [https://lightstonedirect.com/dpn] Lightstone DIRECT invites you to partner with a $12B AUM real estate institution as you grow your portfolio. Access the same single-asset multifamily and industrial deals Lightstone pursues with its own capital – Lightstone co-invests a minimum of 20% in each deal alongside individual investors like you. You’re an institution. Time to invest like one. What You’ll Learn * The difference between visceral fat (harmful) and subcutaneous fat (protective) * How estrogen improves metabolic health and fat function * Why women are protected from metabolic disease before menopause * What actually happens to body composition after menopause * Why weight loss is biologically harder for women * The role of inflammation in unhealthy fat storage * How brown and beige fat increase calorie burning Key Takeaway Not all fat is bad. Where you store it, how it functions, and how your hormones regulate it matter far more than the number on the scale.   GUEST BIO Dr. Deborah J. Clegg is a leading researcher in metabolism, obesity, and cardiometabolic health, with a focus on how sex hormones influence energy balance and fat distribution. She serves as Vice President for Research at Texas Tech University Health Sciences Center El Paso and has authored more than 150 peer-reviewed publications across nutrition, endocrinology, and metabolic disease. Originally trained as a dietitian, Dr. Clegg earned her PhD in Nutrition from the University of Georgia, an MBA from Boston University, and completed postdoctoral training in obesity research at the University of Cincinnati. Her work bridges basic science and clinical insight to better understand — and improve — how we prevent and treat metabolic disease.   Resources & Links Texas Tech Health Sciences Center (Faculty Page): https://www.cardiometabolichealth.org/faculty/deborah-j-clegg-phd-mba/ [https://www.cardiometabolichealth.org/faculty/deborah-j-clegg-phd-mba/] Research & Publications: Search: Deborah Clegg metabolism research (150+ publications) Referenced Concepts in Episode: * Visceral vs subcutaneous fat * Estrogen and metabolic protection * Brown & beige fat metabolism * Hormone replacement therapy (HRT) timing   Episodes Referenced In This Show #17: From Couch to Everest: Dr. Biff Palmer Discusses His Unlikely Journey to the Top of the World [https://premier-cardiovascular-health-and-performance-podcast.simplecast.com/episodes/17-from-couch-to-everest-dr-biff-palmer-discusses-his-unlikely-journey-to-the-top-of-the-world] #22: Why Weight Loss Stalls—Discussing the Role of Hormones, Metabolic Health, and GLP-1 Mimetics with Dr. Marguerite Weston [https://premier-cardiovascular-health-and-performance-podcast.simplecast.com/episodes/22-why-weight-loss-stallsdiscussing-the-role-of-hormones-metabolic-health-and-glp-1-mimetics-with-dr-marguerite-weston]   LET’S CONNECT: Work with Dr. Chris Huff: Premier Cardiovascular Health [https://www.premiercardiohealth.com/] Facebook: https://www.facebook.com/chris.huff.9480 [https://www.facebook.com/chris.huff.9480] Instagram: @hufcm [https://www.instagram.com/hufcm] Disclaimer: The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before making any decisions about your health or medical treatment.

19. mar. 202650 min