A Conversation with CIRM's President and CEO | Jonathan Thomas, PhD, JD

Stem Cells and Neurological Applications | Jennifer Graves, MD, PhD

This episode of the reGEN Podcast features our conversation with Jennifer Graves, MD, PhD, who serves as a clinical professor of neurosciences and as a clinical trial expert with the Sanford Stem Cell Clinical Center Alpha Clinic at UC San Diego. Her work includes a focus on Multiple Sclerosis and emerging therapeutic applications for this and other neurological conditions with stem cells and regenerative medicine. Graves oversees active clinical trials at the UC San Diego Alpha Clinic for MS and is a prolific published researcher. Hosted by Bobby Gordon, MA, MBA This episode was recorded on Aug. 18, 2025, and information presented herein is current at the time of recording. Watch on YouTube: https://youtu.be/GoTI9QZ-V-U [https://youtu.be/GoTI9QZ-V-U]

Sanford Stem Cell Clinical Center | Sheldon Morris, MD, MPH

This episode features Sheldon Morris, MD, MPH, and an overview of the Sanford Stem Cell Clinical Center where Morris serves as director. The Clinical Center at UC San Diego encompasses a wide scope of services and outreach, including the California Institute for Regenerative Medicine (CIRM) Alpha Clinic, clinical trials, community engagement, CIRM grant application assistance and management. We discuss the importance of the collaborative nature of the Clinical Center partnering with trial experts from UC San Diego Health, industry leaders and other researchers for novel discoveries and therapeutics related to stem cells, regenerative medicine and gene therapies. Hosted by Bobby Gordon, MA, MBA This episode was recorded on April 7, 2025, and information presented is current as of the date of this recording. Watch on YouTube: https://youtu.be/5E_YA0-PKm8 [https://youtu.be/5E_YA0-PKm8]

A Conversation with CIRM's President and CEO | Jonathan Thomas, PhD, JD

This episode features our conversation with Jonathan Thomas, PhD, JD, President and CEO of the California Institute for Regenerative Medicine (CIRM). Thomas was previously the chair of the CIRM governing board from June 2011 to March 2023 and has played an integral role in supporting patient-centric research, strategies and outcomes within the Alpha Clinic network and UC San Diego's Sanford Stem Cell Institute. We discuss his history with CIRM and the impact the organization has had across California. Thomas has a long-standing commitment to patient advocacy. He spent more than 15 years on the board of the Crippled Children's Society of Southern California and served as chair for four years. The organization, now called AbilityFirst, assists children with spinal cord injuries and mental disabilities that could be targets of stem cell therapies. Hosted by Bobby Gordon, MA, MBA This episode was recorded on Oct. 17, 2025, and information presented herein is current at the time of recording.

Stem Cells and Cancer, In Vivo Discoveries

Our conversation with Tannishtha Reya, PhD, reviews her work and publications on understanding the mechanisms that drive cancer initiation, progression, and therapy resistance. Her research also includes developing high resolution in vivo imaging approaches to map normal stem cell behavior and interactions within a living organism, to define how these change during cancer formation. Tannishtha is the associate director for Translational Research and director of the Irving Drug Discovery Program at Columbia's Herbert Irving Comprehensive Cancer Center. She is also a former professor with the UC San Diego School of Medicine. An expert in how stem cells fuel cancer growth, she is known for co-authoring a publication in Nature in 2001 that coined the term 'cancer stem cell' to describe how some cancer cells can mirror the properties of stem cells in normal tissues. Reya's laboratory has uncovered critical pathways and therapeutic targets in leukemia and pancreatic cancer, contributing to clinical trials and approvals for new therapies. She has been recognized for her contributions to the field with many prestigious awards, including an NIH Director's Pioneer Award and an NCI Outstanding Investigator Award. Hosted by Bobby Gordon, MA, MBA This episode was recorded on Oct. 16, 2025, and information is current as of the time of this recording.

Novel Therapeutics and Discoveries | Leo D. Wang, MD, PhD

Our conversation with Leo D. Wang, MD, PhD, includes unique insights into novel discoveries and therapeutics for HIV, diabetes, cancer and other conditions. As the director of the City of Hope Alpha Clinic, we discuss the innovative and collaborative nature of the California Institute for Regenerative Medicine (CIRM) Alpha Clinic network. The City of Hope was the first of now nine CIRM Alpha Clinics, designed to improve patient access to stem cell and regenerative medicine clinical trials for all Californians. Leo Wang also serves as an associate professor in the Departments of Pediatrics and Immuno-Oncology, and the division chief of cell, gene, and transplantation therapy at City of Hope, a cancer hospital located outside of Los Angeles, CA, with additional affiliate locations. He leads a research lab dedicated to reprogramming the immune system to fight childhood cancers, where his team works to modify the body's own immune cells to target and destroy cancer cells. Additionally, his lab studies how these engineered cellular therapies interact with tumors and the native immune system. Wang also oversees clinical trials that use these "living medicines" to treat pediatric brain tumors and other aggressive cancers. Hosted by Bobby Gordon, MA, MBA This episode was recorded on Oct. 17, 2025, and information is current as of the time of this recording.