July 01, 2026| Tregzi Approved — Orca Bio Opens a New Lane in Cell Therapy

July 01, 2026| Tregzi Approved — Orca Bio Opens a New Lane in Cell Therapy

FDA approves Orca Bio's Tregzi — the first precision-engineered cell therapy for allogeneic transplant, sparking IPO speculation. Plus BridgeBio secures $1B from Sixth Street and KKR at a 100%+ conversion premium, Ipsen's $2.55B deal spree continues with Memo Therapeutics,Merck scraps Alzheimer's drug MK-1167 as AlzeCure lands a $2.2B QuantumCell partnership, and FDA warns Sanofi's Genzyme over Altuviiio production.   Visit us at www.thepharmacloseout.com pharma, biotech, FDA, clinical trials, drug approvals, OrcaBio, Tregzi, BridgeBio, Ipsen, Merck, Alzheimer's, cell therapy

Jun 30, 2026 | NEJM Retracts Tavneos Pivotal Trial; Ionis Tryngolza PDUFA Today

NEJM retracts Amgen's ADVOCATE study after FDA findsendpoint data for 9 patients re-evaluated post-unblinding. Plus: Ionis faces the Tryngolza sNDA PDUFA in severe hypertriglyceridemia, AbbVie's Epkinly delivers chemo-free PFS in R/R DLBCL, Ipsen acquires Kartos for up to $1.75B,and Roche enters the TED race with Enspryng Priority Review. Visit us at www.thepharmacloseout.com pharma, pharmaceutical, FDA, clinical trials, biotech, drugapprovals, healthcare, pharma podcast, The Pharma Closeout, Tavneos, avacopan,Amgen, NEJM retraction, ADVOCATE study, olezarsen, Tryngolza, IonisPharmaceuticals, epcoritamab, Epkinly, AbbVie, Genmab, DLBCL, Enspryng,satralizumab, Roche, thyroid eye disease, Ipsen, Kartos Therapeutics,navtemadlin, myelofibrosis, Zymeworks, Theravance, ZORYVE, roflumilast,Arcutis, Foundayo, orforglipron, Eli Lilly, Gilead, efzimfotase alfa,AstraZeneca, hypophosphatasia, FDA PreCheck, Lilly, Regeneron

Jun 26, 2026 | FDA Approves Viridian for Thyroid Eye Disease; Merck KGaA's $11.3B Bio-Techne Deal

FDA breaks Amgen's Tepezza monopoly with Viridian's Lumvoa approval in thyroid eye disease. Plus Merck KGaA's $11.3B Bio-Techne acquisition, Biogen gutting the Apellis pipeline post-$5.6B deal, CHMP moves to revoke Tavneos, and Lilly's orforglipron PDUFA lands Monday. Www.thepharacloseout.com pharma, pharmaceutical, FDA, clinical trials, biotech, drug approvals, healthcare, pharma podcast, The Pharma Closeout, Viridian Therapeutics, Lumvoa, veligrotug, thyroid eye disease, Amgen, Tepezza, Merck KGaA, Bio-Techne, Biogen, Apellis, Syfovre, Eli Lilly, orforglipron, Moderna, Ionis, Tryngolza, Ardelyx, Xphozah, Sanofi, Tavneos, avacopan, CHMP, Keytruda, Padcev, Replimune, Lycia, Dr. Reddy's, Gilead, AbbVie, M&A, GLP-1, Lilly, Merck, J&J

Jun 25, 2026 | Ionis Tryngolza FDA Label Expansion Hits Commercial Inflection

FDA approves Ionis Tryngolza as first treatment to reduce pancreatitis risk in severe hypertriglyceridemia — a potential blockbuster expansion. Merck KGaA acquires Bio-Techne for $11.3B in largest deal in a decade. SCOTUS limits Bayer Roundup state-level claims; Gilead-Pfizer ADC divergence deepens. pharma, pharmaceutical, FDA, clinical trials, biotech, drug approvals, healthcare, pharma podcast, The Pharma Closeout, Ionis, Tryngolza, olezarsen, hypertriglyceridemia, pancreatitis, FDA approval, Merck KGaA, Bio-Techne, Bayer, Roundup, SCOTUS, Gilead, Trodelvy, Pfizer, Seagen, ADC, AbbVie, Apogee, Ollin, Vabysmo, Novartis, Antares, pelacarsen, RQ Bio, Oblenio Bio, Remix, Passage Bio, Eli Lilly, orforglipron, Recordati, Lilly, Roche, Merck

Jun 24, 2026 | FDA Approves Gilead's Trodelvy for Front-Line TNBC; Lilly's $1.9B Abbisko Deal

Gilead's Trodelvy wins front-line triple-negative breast cancer approval — and the stock barely moves. Lilly expands its Abbisko partnership to $1.9B, Novartis pays $105M upfront to Antares for undruggable cancer targets, and three ADC stories in two days force a class-level reckoning. pharma, pharmaceutical, FDA, clinical trials, biotech, drug approvals, healthcare, pharma podcast, The Pharma Closeout, Trodelvy, sacituzumab govitecan, Gilead, TNBC, triple-negative breast cancer, FDA approval, Eli Lilly, Abbisko Therapeutics, Novartis, Antares Therapeutics, ADC, antibody-drug conjugate, Pfizer, Ibrance, Ionis, triglycerides, Ollin, Vabysmo, ADC Therapeutics, Zynlonta, HHS, pelacarsen, BioNTech, Lilly, Roche