The Well Woman Podcast with Dr Frances Pitsilis

Well Woman Podcast - Is Metformin Good or Bad?

22 min · 8. maj 2026
Billede af episoden Well Woman Podcast - Is Metformin Good or Bad?

Description

Metformin has been controversial or even rubbished in some quarters.  Here I give extensive details regarding why some regard it as unsuitable but why there is overwhelming evidence that it gives many benefits  that extend to  - anti-aging - prevention of cancer, dementia, heart disease, macular degeneration, kidney disease etc - great for the skin, and also reducing skin cancer. - helpful in Polycystic Ovarian Syndrome, osteoarthritis,  - prevention and management of pre diabetes and diabetes  I literally have dozens of references because of my research in metformin over the years and for my best selling book - Well Woman - link below for book  https://www.google.com/search?client=safari&rls=en&q=buy+well+woman+book&ie=UTF-8&oe=UTF-8 [https://www.google.com/search?client=safari&rls=en&q=buy+well+woman+book&ie=UTF-8&oe=UTF-8] International  https://www.amazon.com.au/Well-Woman-Prescription-Lifelong-Health-ebook/dp/B0DXMSV4VL [https://www.amazon.com.au/Well-Woman-Prescription-Lifelong-Health-ebook/dp/B0DXMSV4VL] The ebook is also available  drfrances.co.nz

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12 episodes

episode Well Woman Podcast - What is DHEA artwork

Well Woman Podcast - What is DHEA

DHEA should be used more but is not, because it's not taught.  DHEA has massive effects on all ages and protects all the organs. It helps prevent the diseases of ageing as well as giving mental and physical resilience and quality of life. I give details in my book - Well Woman  What is DHEA?  It is short for dehydroepiandrosterone.  I call it the quality of life hormone because it is 10-20 times more abundant in the body than any other hormone including vitamin D, progesterone, oestrogen, and testosterone.  DHEA has associated with it a lot of important factors which include less depression and better psychological profiles;  Also, there is lower perceived stress at work. So, how does this all happen?  As people get older their DHEA declines but also what drains it more is stress and disease. DHEA specifically has many effects on helping to prevent heart disease   We also know that DHEA stimulates bone formation and that is because it turns into progesterone, oestrogen and testosterone which further helps bone.  When it comes to women, it helps their sexual satisfaction, fertility because it improves the egg, and it also improves vaginal tissue function.  It is particularly good in post-menopausal women who don’t want to have oestrogen.  In fact I will often in older people, just use some DHEA and melatonin to help quality of life.    DHEA also helps to prevent, improve and reduce autoimmune diseases like rheumatoid arthritis.  It also helps in allergy.  DHEA has a lot of work that it does in the brain DHEA reduces metabolic syndrome, diabetes and helps you lose weight. DHEA helps chronic kidney disease, reduces inflammation and oxidation, and reduces mortality. DHEA needs to be prescribed carefully by an experienced doctor.  REFERENCES 1. DHEA Monograph. Alt Med Rev. Vol 6, Number 3, 2001 2. Krzysztof Rutkowski et al. Review Article. Dehydroepiandrosterone (DHEA): Hypes and Hopes Drugs (2014) 74:1195–1207  3. Fernand Labrie. Chapter 4 – DHEA, Important Source of Sex Steroids in Men and Even More in Women. Progress in Brain Research. Volume 182, 2010, Pages 97–148 4. Abdulmaged M. Traish et al. Dehydroepiandrosterone (DHEA)—A Precursor Steroid or an Active Hormone in Human Physiology. The Journal of Sexual Medicine. Volume 8, Issue 11, pages 2960–2982, November 2011 5. N. Pluchino, et al., Neurobiology of DHEA and effects on sexuality, mood and cognition, J. Steroid Biochem. Mol. Biol. (2014), http://dx.doi.org/10.1016/j.jsbmb.2014.04.012  6. Rebecca K Sripada et al. DHEA Enhances Emotion Regulation Neurocircuits and Modulates Memory for Emotional Stimuli. Neuropsychopharmacology (2013) 38, 1798–1807; doi:10.1038/npp.2013.79; published online 24 April 2013  7. Lennartsson A-K, Theorell T, Rockwood AL, Kushnir MM, Jonsdottir IH (2013) Perceived Stress at Work Is Associated with Lower Levels of DHEA-S. PLoS ONE 8(8): e72460. doi:10.1371/journal.pone.0072460  8. Jean-Pierre Savineau et al. Role of DHEA in cardiovascular diseases Biochemical Pharmacology 85 (2013) 718–726  9. Edward P. Weiss et al. Dehydroepiandrosterone ( DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans. Aging, May 2011, Vol3. No 5 10. Christiaan Lucas Meuwese and Juan Jesus Carrero REVIEW ARTICLE  11. Chronic Kidney Disease and HypothalamicePituitary Axis Dysfunction: The Chicken or the Egg? Archives of Medical Research 44 (2013) 591e600  12. Moise ́s E. Bauer et al. Psychoneuroendocrine interventions aimed at attenuating immunosenescence: a review. Biogerontology DOI 10.1007/s10522-012-9412-5  13. Nikolaos Samaras et al. A Review of Age-Related Dehydroepiandrosterone Decline and Its Association with Well-Known Geriatric Syndromes: Is Treatment Beneficial? REJUVENATION RESEARCH Volume 16, Number 4, 2013&nbs

8. juli 20268 min
episode Well Woman Podcast - Dealing with Midriff Weight gain artwork

Well Woman Podcast - Dealing with Midriff Weight gain

Dr. Frances Pitsilis hosted an episode of the Well Woman podcast focused on addressing midriff weight gain, particularly in women over 40 and after menopause. She discussed how hormonal imbalances, particularly declining progesterone levels, can contribute to weight gain and metabolic issues. Dr. Pitsilis explained her approach to treating weight gain, which includes testing for hormone imbalances, thyroid function, and metabolic syndrome, as well as addressing potential toxic exposures to chemicals and heavy metals. She outlined a comprehensive treatment plan involving lifestyle changes, dietary modifications, supplements, and medications like metformin and low-dose naltrexone, emphasizing the importance of addressing underlying causes rather than just using appetite suppressants. drfrances.co.nz skinfresh.co.nz

28. maj 202618 min