Opelika Jane Doe: The Child No One Knew (E169)

Anthonette Cayedito: The Knock on the Door in the Night (E171)

In April 1986, nine-year-old Anthonette Cayedito was at home in Gallup, New Mexico, while her mother was asleep. During the early hours of the morning, someone knocked on the front door. Believing it might be a family member, Anthonette answered. She was never seen again. Over the years, mysterious phone calls, possible sightings, and conflicting witness accounts have kept hope alive while also deepening the mystery. Was Anthonette abducted by someone she knew, or was she the victim of a stranger who seized a tragic opportunity? Nearly four decades later, her disappearance remains one of America's most heartbreaking unsolved missing child cases.

Dennis DePue: The Murder, the Phone Call, and the Disappearance (E170)

In April 1990, Dennis DePue called police to report that his estranged wife, Marilynn DePue, had disappeared after the couple met to discuss their divorce. At first, it appeared to be another missing persons investigation but detectives soon uncovered evidence that transformed the case into a nationwide manhunt. As Dennis fled across multiple states, investigators pieced together a timeline of deception, violence, and desperation. The pursuit ultimately ended with a dramatic confrontation, but the case would gain lasting notoriety after inspiring one of the most unforgettable segments ever featured on Unsolved Mysteries. More than three decades later, the story remains a powerful example of how domestic violence can escalate into tragedy and how one phone call concealed a far darker reality.

Opelika Jane Doe: The Child No One Knew (E169)

In January 2012, the remains of a young girl were discovered in a wooded area near Opelika, Alabama. She appeared to have been between four and seven years old, but no one knew her name, no missing persons report matched her description, and no family came forward to claim her. For years, investigators referred to her simply as "Opelika Jane Doe." As forensic artists reconstructed her face and detectives pursued thousands of leads, one heartbreaking question remained: how could a child seemingly disappear without anyone looking for her? Then, more than a decade later, advances in forensic genetic genealogy finally gave the little girl her name. But even with her identity restored, investigators continue searching for those responsible for her death.

Sunanda Pushkar: The Hotel Room Death That Shook Delhi (E168)

In January 2014, Sunanda Pushkar was found dead in a luxury hotel room in New Delhi, just hours after a series of highly publicized social media exchanges and mounting political controversy involving her husband, Shashi Tharoor. What initially appeared to be a tragic personal loss soon became one of India's most closely watched investigations. Conflicting forensic opinions, changing investigative conclusions, media speculation, and years of legal proceedings left the public wondering what truly happened behind the closed hotel room door. More than a decade later, Sunanda Pushkar's death continues to generate debate, raising difficult questions about evidence, public scrutiny, and the challenge of separating fact from speculation.

Lori Ruff: The Woman Who (E167)

When Lori Erica Ruff