Clinically Significant™

Cervical Cancer Screening and Prevention: Guideline Review and Implementation Challenges

CME Available on the AMA Ed Hub™: https://edhub.ama-assn.org/ama-education/audio-player/10.1001/ama.2025.0002237 [https://edhub.ama-assn.org/ama-education/audio-player/10.1001/ama.2025.0002237] What would it take to make cervical cancer a disease of the past? In this episode of Clinically Significant™, host Maylyn Martinez, MD, MSc, sits down with Rebecca Perkins, MD, MSc, and Jodi Abbott, MD, MSc, MHCM, to break down the evolution of cervical cancer screening - from classic Pap smears to the latest advances in HPV testing and self-collection. Discover the evidence behind the current and draft USPSTF guidelines, learn practical strategies for managing abnormal results, and explore how smarter implementation and a focus on reducing disparities in access to screening could help eliminate cervical cancer for good. Tune in for expert insights, high-yield clinical pearls, and actionable ideas that can transform patient care. Learn more about women's health [https://edhub.ama-assn.org/collections/42139], cervical cancer prevention [https://edhub.ama-assn.org/collections/5554], and current guidelines [https://edhub.ama-assn.org/collections/5672] on the AMA Ed Hub™. [https://edhub.ama-assn.org/] Episode Guest: • Rebecca Perkins, MD, MSc - Professor, Obstetrics and Gynecology, Tufts University School of Medicine. Clinically Significant™ is hosted by: * Jodi Abbott, MD, MSc, MHCM: Professor of ObGyn at Boston University Chobanian & Avedisian School of Medicine and Medical Director of the Education Center Curriculum and Outreach for the American Medical Association (AMA) * Maylyn Martinez, MD, MSc: Assistant Professor of Medicine at the University of Chicago and former contributing host, writer, and producer for the JAMA Clinical Reviews podcast * Avir Mitra, MD: Associate Professor of Emergency Medicine at NYU Langone and contributing editor at Radiolab (WNYC) CME Info: * Accreditation Statement: The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. * Designation Statement: The AMA designates this Enduring Material activity for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. * Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to: * 0.5 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program; * 0.5 Self-Assessment points in the American Board of Otolaryngology - Head and Neck Surgery's (ABOHNS) Continuing Certification program; * 0.5 MOC points in the American Board of Pediatrics' (ABP) Maintenance of Certification (MOC) program; and * 0.5 Lifelong Learning points in the American Board of Pathology's (ABPath) Continuing Certification program * 0.5 Credit towards the CME Requirement(s) of the American Board of Surgery's Continuous Certification program It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit. CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Microplastics Infiltrate Our Bodies. How Can Physicians Help?

CME Available on the AMA Ed Hub™: https://edhub.ama-assn.org/ama-education/audio-player/10.1001/ama.2025.0002215 [https://edhub.ama-assn.org/ama-education/audio-player/10.1001/ama.2025.0002215] When plastic breaks down into microplastic particles, not only do they pollute the environment—numerous studies have found they infiltrate multiple organ systems and tissues. In fact, a 2022 study in Environmental International estimated that microplastics were circulating in the blood of 77% of Americans. With growing evidence of the health risks posed by microplastics, what can physicians do to respond to this health threat? In this episode of Clinically Significant™, hosts Jodi Abbott, MD, MSc, MHCM, Avir Mitra, MD, and special guest host Lindsey Realmuto explore what we know about the impact of microplastics on public health and how physicians can adapt their practice to minimize exposure to microplastics. Episode Guests: * Philip J. Landrigan, MD, MSc: Director, Program for Global Public Health and the Common Good, Director of the Global Observatory on Planetary Health, Boston College. * Thais Mauad, MD, PhD: Associate Professor, Department of Pathology, University of São Paulo. * Leonardo Trasande, MD, MPP: Professor of Pediatrics, New York University Grossman School of Medicine. This episode of Clinically Significant™ is hosted by: * Jodi Abbott, MD, MSc, MHCM: Professor of Ob/Gyn at Boston University Chobanian & Avedisian School of Medicine and Medical Director of the Education Center Curriculum and Outreach for the American Medical Association (AMA) * Avir Mitra, MD: Associate Professor of Emergency Medicine at NYU Langone and contributing editor at Radiolab (WNYC) * Lindsey Realmuto, MPH: Lindsey is a Senior Program Manager at the American Medical Association where she serves as a subject matter expert on climate change and environmental health. CME Info: * Accreditation Statement: The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. * Designation Statement: The AMA designates this Enduring Material activity for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. * Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to: * 0.5 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program; * 0.5 Self-Assessment points in the American Board of Otolaryngology - Head and Neck Surgery's (ABOHNS) Continuing Certification program; * 0.5 MOC points in the American Board of Pediatrics' (ABP) Maintenance of Certification (MOC) program; and * 0.5 Lifelong Learning points in the American Board of Pathology's (ABPath) Continuing Certification program * 0.5 Credit towards the CME Requirement(s) of the American Board of Surgery's Continuous Certification program It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit. CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Can AI Help Physicians Detect Sepsis?

CME available on the AMA Ed Hub™: https://edhub.ama-assn.org/ama-education/audio-player/10.1001/ama.2025.0002174 [https://edhub.ama-assn.org/ama-education/audio-player/10.1001/ama.2025.0002174] Sepsis: at its inception, it is difficult to recognize but easy to treat; left unattended, it becomes easy to recognize and difficult to treat. As the adage states, sepsis is notoriously difficult to recognize in its early stages, due to the lack of a definitive diagnostic tool. When left undetected, the outcomes can be devastating. But what if artificial intelligence (AI) could be utilized to detect sepsis in its early stage? In this episode of Clinically Significant™, hosts Jodi Abbott, MD, MSc, MHCM, Maylyn Martinez, MD, MSc, and Avir Mitra, MD, explore the use of AI-tools for early detection of sepsis, including advancements as well as challenges to implementation and generalization. Learn more about sepsis [https://edhub.ama-assn.org/collections/5903/sepsis] and artificial intelligence [https://edhub.ama-assn.org/collections/44024/artificial-intelligence] on the AMA Ed Hub™ [https://edhub.ama-assn.org/searchresults?hd=edhub&q=sepsis]. Episode Guests: * Amy Hassell, MSN, BSN, RN: Chief Nursing Officer at UCHealth * CT Lin, MD: Chief Medical Information Officer (CMIO) at UCHealth-Colorado * Karandeep Singh, MD, MMSc: Jacobs Chancellor's Endowed Chair and Chief Health AI Officer at UC San Diego Health Clinically Significant™ is hosted by: * Jodi Abbott, MD, MSc, MHCM: Professor of ObGyn at Boston University Chobanian & Avedisian School of Medicine and Medical Director of the Education Center Curriculum and Outreach for the American Medical Association (AMA) * Maylyn Martinez, MD, MSc: Assistant Professor of Medicine at the University of Chicago and former contributing host, writer, and producer for the JAMA Clinical Reviews podcast * Avir Mitra, MD: Associate Professor of Emergency Medicine at NYU Langone and contributing editor at Radiolab (WNYC) CME Information: * Accreditation Statement: The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. * Designation Statement: The AMA designates this Enduring Material activity for a maximum of 0.5 AMA PRA Category 1 Credit(s). Physicians should claim only the credit commensurate with the extent of their participation in the activity. * Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to: * 0.5 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program; * 0.5 Self-Assessment points in the American Board of Otolaryngology - Head and Neck Surgery's (ABOHNS) Continuing Certification program; * 0.5 MOC points in the American Board of Pediatrics' (ABP) Maintenance of Certification (MOC) program; and * 0.5 Lifelong Learning points in the American Board of Pathology's (ABPath) Continuing Certification program * 0.5 Credit towards the CME Requirement(s) of the American Board of Surgery's Continuous Certification program It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit. CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Ambulate TID or Hospital-Acquired Disability (HAD)?

CME available on the AMA Ed Hub™: https://edhub.ama-assn.org/ama-education/audio-player/10.1001/ama.2025.0002176 [https://edhub.ama-assn.org/ama-education/audio-player/10.1001/ama.2025.0002176] Why is it that individuals who are hospitalized often leave the hospital with decreased mobility and functional abilities? In this episode of Clinically Significant™, host Maylyn Martinez, MD, MSc explores the causes, diagnosis, and treatment of Hospital-acquired disability (HAD). Are fall prevention efforts helping or harming hospitalized patients? Can societal norms and public health policies shift away from bed rest and encourage safe mobility for patients with acute medical illness? Tune in for the answers to these questions and actionable steps health care providers can take to prevent HAD. Learn more about geriatrics [https://edhub.ama-assn.org/collections/5668/geriatrics] and physical therapy [https://edhub.ama-assn.org/collections/42059/physical-therapy] on the AMA Ed Hub™ [https://edhub.ama-assn.org/]. Episode Guests: * Kenneth Covinsky, MD, MPH: Clinician-researcher at University of California San Francisco * Michael Friedman, PT, MBA: Sr. Director, Strategic Programs Director, Johns Hopkins Activity and Mobility Promotion (JH-AMP) * Erik Hans Hoyer, MD: Co-director, Activity and Mobility Promotion Program, Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine * Alan M. Jette, PhD, MPH, PT: Professor Emeritus, Physical Therapy, Boston University Sargent College of Health & Rehabilitation Sciences Clinically Significant™ is hosted by: * Jodi Abbott, MD, MSc, MHCM: Professor of ObGyn at Boston University Chobanian & Avedisian School of Medicine and Medical Director of the Education Center Curriculum and Outreach for the American Medical Association (AMA) * Maylyn Martinez, MD, MSc: Assistant Professor of Medicine at the University of Chicago and former contributing host, writer, and producer for the JAMA Clinical Reviews podcast. * Avir Mitra, MD: Associate Professor of Emergency Medicine at NYU Langone and contributing editor at Radiolab (WNYC). CME Information: * Accreditation Statement: The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. * Designation Statement: The AMA designates this Enduring Material activity for a maximum of 0.5 AMA PRA Category 1 Credit(s). Physicians should claim only the credit commensurate with the extent of their participation in the activity. * Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to: * 0.5 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program; * 0.5 Self-Assessment points in the American Board of Otolaryngology - Head and Neck Surgery's (ABOHNS) Continuing Certification program; * 0.5 MOC points in the American Board of Pediatrics' (ABP) Maintenance of Certification (MOC) program; and * 0.5 Lifelong Learning points in the American Board of Pathology's (ABPath) Continuing Certification program * 0.5 Credit towards the CME Requirement(s) of the American Board of Surgery's Continuous Certification program It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit. CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Countering Medical Misinformation in the Clinical Setting (and Beyond)

CME available on the AMA Ed Hub™: https://edhub.ama-assn.org/ama-education/audio-player/10.1001/ama.2025.0002175 [https://edhub.ama-assn.org/ama-education/audio-player/10.1001/ama.2025.0002175] Widespread medical misinformation on social media platforms like TikTok, Instagram, and YouTube can negatively impact patient health and erode trust in health care professionals. In this episode, hosts Jodi Abbott, MD, MSc, MHCM, Maylyn Martinez, MD, MSc, and Avir Mitra, MD, and guest Shaalini Ramanadhan, MD, address the urgent issue of unreliable health information online. Tune in to explore how medical professionals can effectively counter health misinformation, restore patient confidence in health care professionals and evidence-based health care decisions, and mitigate the influence of social media misinformation in both clinical settings and online. Learn more about medical misinformation [https://edhub.ama-assn.org/searchresults?hd=edhubLite&q=misinformation&SearchSourceType=1&exPrm_qqq={DEFAULT_BOOST_FUNCTION}%22misinformation%22&exPrm_hl.q=misinformation&fl_IsDataSupplement=false], public health [https://edhub.ama-assn.org/collections/42128/public-health], and reproductive health [https://edhub.ama-assn.org/collections/46443/reproductive-health] on the AMA Ed Hub™ [https://urldefense.com/v3/__https://edhub.ama-assn.org/__;!!MyIu0v6UfBA57LoN!60HrOFh0xW9HcZdVAaTPXOliQoJhKe8AS-weJAd1FU3vGwtoM7ydZBr_tigYZoN5ei0mR3dtV71INaiEZ3cQpODDj0OQMQ$]. Episode Guest: • Shaalini Ramanadhan, MD: Assistant Professor of Obstetrics and Gynecology, Oregon Health & Science University School of Medicine. Dr Ramanadhan is a generalist obstetrician and gynecologist and a family planning specialist. Her interests include family planning, contraception, opioid use disorder in pregnancy and financial literacy. Clinically Significant™ is hosted by: * Jodi Abbott, MD, MSc, MHCM: Professor of Ob/Gyn at Boston University Chobanian & Avedisian School of Medicine and Medical Director of the Education Center Curriculum and Outreach for the American Medical Association (AMA). * Maylyn Martinez, MD, MSc: Assistant Professor of Medicine at the University of Chicago and former contributing host, writer, and producer for the JAMA Clinical Reviews podcast. * Avir Mitra, MD: Associate Professor of Emergency Medicine at NYU Langone and contributing editor at Radiolab (WNYC). Resources: * Planned Parenthood [https://www.plannedparenthood.org/] | TikTok [https://www.tiktok.com/@plannedparenthood] | Instagram [https://www.instagram.com/plannedparenthood/] | YouTube [https://www.youtube.com/user/plannedparenthood] * Bedsider.org [https://www.bedsider.org/] | TikTok [https://www.tiktok.com/@bedsider] | Instagram [https://www.instagram.com/bedsider/] * Dr Jennifer Lincoln [https://www.drjenniferlincoln.com/] | TikTok [https://www.tiktok.com/@drjenniferlincoln] | Instagram [https://www.instagram.com/drjenniferlincoln/?hl=en] | YouTube [https://www.youtube.com/@DrJenniferLincoln] * Dr Zachary Rubin [https://www.oakbrookallergists.com/our-team/zachary-e-rubin-md/] | TikTok [https://www.tiktok.com/@rubin_allergy?lang=en] CME Information: * Accreditation Statement: The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. * Designation Statement: The AMA designates this Enduring Material activity for a maximum of 0.5 AMA PRA Category 1 Credit(s). Physicians should claim only the credit commensurate with the extent of their participation in the activity. * Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to: * 0.5 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program; * 0.5 Self-Assessment points in the American Board of Otolaryngology - Head and Neck Surgery's (ABOHNS) Continuing Certification program; * 0.5 MOC points in the American Board of Pediatrics' (ABP) Maintenance of Certification (MOC) program; and * 0.5 Lifelong Learning points in the American Board of Pathology's (ABPath) Continuing Certification program * 0.5 Credit towards the CME Requirement(s) of the American Board of Surgery's Continuous Certification program It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit. CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.