Starting GLP-1 Medications: How to Dose, Up-Titrate & Reduce Side Effects of GLP-1

IBS, Anxiety & Depression: The Link Between Hormone Imbalance and Gut Microbiome

In this episode of Hormones & Hope, Dr. Chhaya Makhija sits down with Dr. Melissa Mondala, Family & Integrative Medicine Specialist, for a powerful conversation about the connection between lifestyle, gut health, and emotional well-being. Drawing from both personal experience and years of clinical practice, Dr. Mondala explains how the gut and brain work together, why nutrition and exercise are essential for mental health, and how sleep, stress management, and social connection can help build emotional resilience. She also shares practical tips for making healthy habits stick, overcoming setbacks, and creating routines that work in real life—not just for a few weeks, but for the long term Whether you're supporting your own mental health or helping someone you love, this episode offers hope, practical guidance, and a reminder that meaningful change often starts with simple daily choices. Download the Free Guide 'Your Health on GLP-1' Here: https://dr-chhaya.myflodesk.com/glp1 [https://www.buzzsprout.com/admin/2503047/%20https://dr-chhaya.myflodesk.com/glp1] Follow Dr. Chhaya Makhija here: https://www.instagram.com/chhayamakhijamd/ [https://www.instagram.com/chhayamakhijamd/]https://www.facebook.com/unifiedendocrine [https://www.facebook.com/unifiedendocrine] https://unifiedendocrinecare.com/ [https://unifiedendocrinecare.com/]https://www.youtube.com/@chhayamakhijamd [https://www.youtube.com/@chhayamakhijamd] https://www.linkedin.com/in/chhayamakhijamd/ [https://www.linkedin.com/in/chhayamakhijamd/] Email: connect@unifiedendocrinecare.com [connect@unifiedendocrinecare.com] Follow Dr. Mondala here: https://www.instagram.com/drmelissamondala/ [https://www.instagram.com/drmelissamondala/] https://drlifestyle.org/ [https://drlifestyle.org/] https://www.instagram.com/drlifestyleclinic/ [https://www.instagram.com/drlifestyleclinic/] Dr. Melissa Mondala, MD is a double board-certified physician in Family Medicine and Lifestyle Medicine, with advanced fellowships in training in integrative psychiatry and integrative medicine. Dr. Mondala is the President and co-founder of Dr. Lifestyle Clinic in Newport Beach — the first Lifestyle and Integrative Direct Primary Care and Rheumatology clinic The clinic has been recognized as a Public Health Site of Excellence and she is a best-selling author of Embody Lifestyle Medicine and well sought out speaker. Disclaimer: This podcast is for educational, informational, and entertainment purposes only. It’s not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance. 🔔 Don’t forget to like, subscribe, and hit the bell icon! .

Statins, Calcium Score & Cholesterol: What You Need to Know About Preventing Heart Disease

In Part 2 of this powerful conversation, Dr. Chhaya Makhija sits down with preventive cardiologist Dr. Sourbha S. Dani to discuss how we can identify and prevent heart disease before it becomes a life-changing event. Together, they break down the screening tests, lab markers, and imaging studies that can help uncover cardiovascular risk years before symptoms develop. From ApoB and Lipoprotein(a) to coronary calcium scores, insulin resistance, statins, and lifestyle interventions, this episode provides a practical roadmap for anyone looking to take a proactive approach to heart health. Dr. Chhaya also shares her perspective as a preventive endocrinologist, highlighting the metabolic factors that often drive cardiovascular disease and why early intervention matters. If you have a family history of heart disease, elevated cholesterol, diabetes, or simply want to optimize your long-term health, this episode is packed with actionable insights. Download the Free Guide 'Your Health on GLP-1' Here: https://dr-chhaya.myflodesk.com/glp1 [https://www.buzzsprout.com/admin/2503047/%20https://dr-chhaya.myflodesk.com/glp1] Follow Dr. Chhaya Makhija here: https://www.instagram.com/chhayamakhijamd/ [https://www.instagram.com/chhayamakhijamd/]https://www.facebook.com/unifiedendocrine [https://www.facebook.com/unifiedendocrine] https://unifiedendocrinecare.com/ [https://unifiedendocrinecare.com/]https://www.youtube.com/@chhayamakhijamd [https://www.youtube.com/@chhayamakhijamd] https://www.linkedin.com/in/chhayamakhijamd/ [https://www.linkedin.com/in/chhayamakhijamd/] Email: connect@unifiedendocrinecare.com [connect@unifiedendocrinecare.com] Follow Dr. Dani here: https://www.linkedin.com/in/sourbhadani/ [https://www.linkedin.com/in/sourbhadani/] https://physicians.lahey.org/details/4012 [https://physicians.lahey.org/details/4012] Dr. Dani is a non-invasive cardiologist with a special focus on prevention and premature heart disease at Lahey Hospital and Medical Center in Burlington, Massachusetts. He serves as the Program Director for the Cardiovascular Fellowship, Director of Inpatient Cardiac Services, Director of the Adult Congenital Heart Disease Center, and Co-Director of the region's first South Asian Metabolic Program. He is also an Associate Professor at the University of Massachusetts Medical School and Tufts University. In addition to his clinical and academic roles, Dr. Dani is a cardiovascular outcomes and healthcare economics researcher, collaborating with the Smith Center for Outcomes Research at Beth Israel Deaconess Medical Center in Boston and the Center for Cardiovascular Research (CVER) at Tufts University. Disclaimer: This podcast is for educational, informational, and entertainment purposes only. It’s not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance. 🔔 Don’t forget to like, subscribe, and hit the bell icon!

From Ethnicity to Lifestyle: Understanding Heart Disease Risk in South East Asians

In Part 1 of this two-part series, Dr. Chhaya Makhija sits down with preventive cardiologist Dr. Sourbha Dani to discuss the growing epidemic of premature heart disease in South Asian communities around the world. Dr. Dani explains why many South Asians develop diabetes, high blood pressure, and heart disease at younger ages, why BMI can be misleading, and why being "healthy on paper" doesn't always tell the full story. He also shares how lifestyle choices can dramatically influence long-term risk—even in individuals with a strong family history of cardiovascular disease. The discussion covers the concept of the "thin-fat phenotype," where individuals may appear lean while carrying excess visceral fat and significant metabolic risk.  Next week, Part 2 dives into advanced testing, cholesterol markers, risk assessment tools, statins, and the evolving role of GLP-1 medications in cardiovascular prevention. If you're interested in optimizing your metabolic health, understanding your cardiovascular risk, or learning how to prevent disease before it starts, this episode is a must-listen. Download the Free Guide 'Your Health on GLP-1' Here: https://dr-chhaya.myflodesk.com/glp1 [https://www.buzzsprout.com/admin/2503047/%20https://dr-chhaya.myflodesk.com/glp1] Follow Dr. Chhaya Makhija here: https://www.instagram.com/chhayamakhijamd/ [https://www.instagram.com/chhayamakhijamd/]https://www.facebook.com/unifiedendocrine [https://www.facebook.com/unifiedendocrine] https://unifiedendocrinecare.com/ [https://unifiedendocrinecare.com/]https://www.youtube.com/@chhayamakhijamd [https://www.youtube.com/@chhayamakhijamd] https://www.linkedin.com/in/chhayamakhijamd/ [https://www.linkedin.com/in/chhayamakhijamd/] Email: connect@unifiedendocrinecare.com [connect@unifiedendocrinecare.com] Follow Dr. Dani here: https://www.linkedin.com/in/sourbhadani/ [https://www.linkedin.com/in/sourbhadani/] https://physicians.lahey.org/details/4012 [https://physicians.lahey.org/details/4012] Dr. Dani is a non-invasive cardiologist with a special focus on prevention and premature heart disease at Lahey Hospital and Medical Center in Burlington, Massachusetts. He serves as the Program Director for the Cardiovascular Fellowship, Director of Inpatient Cardiac Services, Director of the Adult Congenital Heart Disease Center, and Co-Director of the region's first South Asian Metabolic Program. He is also an Associate Professor at the University of Massachusetts Medical School and Tufts University. In addition to his clinical and academic roles, Dr. Dani is a cardiovascular outcomes and healthcare economics researcher, collaborating with the Smith Center for Outcomes Research at Beth Israel Deaconess Medical Center in Boston and the Center for Cardiovascular Research (CVER) at Tufts University. Disclaimer: This podcast is for educational, informational, and entertainment purposes only. It’s not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance. 🔔 Don’t forget to like, subscribe, and hit the bell icon!

Triple Agonists: The Next Big Thing in GLP-1 & Metabolic Medicine?

In this episode of Hormones and Hope, Dr. Chhaya Makhija breaks down one of the most rapidly evolving areas of modern medicine: GLP-1 receptor agonists. With new medications, expanding FDA approvals, and growing conversations about weight loss, diabetes, longevity, and metabolic health, it can be difficult to separate evidence-based science from social media hype. Dr. Makhija explains the differences between semaglutide, tirzepatide, and the highly anticipated triple agonist retatrutide while helping listeners understand what we know today—and what remains under investigation. She also discusses why personalized care matters when prescribing GLP-1 medications, how these therapies may impact long-term health beyond weight loss, and why patients should be cautious about compounded or unapproved versions of emerging drugs. Whether you're currently taking a GLP-1 medication, considering one, or simply curious about the future of metabolic medicine, this episode provides a practical, science-backed overview of where the field stands in 2026. Sign Up for The M3 Masterclass with Dr.  Makhija: https://zoom.us/meeting/register/llQXKQSGRCKVpZBMHoqb2A#/ [https://zoom.us/meeting/register/llQXKQSGRCKVpZBMHoqb2A#/] Download the Free Guide 'Your Health on GLP-1' Here: https://dr-chhaya.myflodesk.com/glp1 [https://www.buzzsprout.com/admin/2503047/%20https://dr-chhaya.myflodesk.com/glp1] Follow Dr. Chhaya Makhija here: https://www.instagram.com/chhayamakhijamd/ [https://www.instagram.com/chhayamakhijamd/]https://www.facebook.com/unifiedendocrine [https://www.facebook.com/unifiedendocrine] https://unifiedendocrinecare.com/ [https://unifiedendocrinecare.com/]https://www.youtube.com/@chhayamakhijamd [https://www.youtube.com/@chhayamakhijamd] https://www.linkedin.com/in/chhayamakhijamd/ [https://www.linkedin.com/in/chhayamakhijamd/] Email: connect@unifiedendocrinecare.com [connect@unifiedendocrinecare.com] Disclaimer: This podcast is for educational, informational, and entertainment purposes only. It’s not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance. 🔔 Don’t forget to like, subscribe, and hit the bell icon!

Starting GLP-1 Medications: How to Dose, Up-Titrate & Reduce Side Effects of GLP-1

Starting a GLP-1 medication can feel overwhelming, especially with so much misinformation online about dosing, side effects, and “maximum” doses. In this episode, Dr. Chhaya Makhija explains how GLP-1 dose titration actually works and why more medication is not always better. From semaglutide medications like Ozempic and Wegovy to tirzepatide options like Mounjaro and Zepbound, she shares how she approaches dosing with her own patients, what signs she monitors, and why individualized care matters so much in metabolic health. She also discusses body composition, inflammation, side effect management, oral GLP-1 medications, and the importance of ongoing communication with your healthcare provider throughout your journey. Whether you’re considering starting a GLP-1 medication, currently adjusting your dose, or simply trying to better understand how these medications work, this episode offers a realistic approach to metabolic health and weight management. Sign Up for The M3 Masterclass with Dr.  Makhija: https://zoom.us/meeting/register/llQXKQSGRCKVpZBMHoqb2A#/ [https://zoom.us/meeting/register/llQXKQSGRCKVpZBMHoqb2A#/] Download the Free Guide 'Your Health on GLP-1' Here: https://dr-chhaya.myflodesk.com/glp1 [ https://dr-chhaya.myflodesk.com/glp1] Follow Dr. Chhaya Makhija here: https://www.instagram.com/chhayamakhijamd/ [https://www.instagram.com/chhayamakhijamd/]https://www.facebook.com/unifiedendocrine [https://www.facebook.com/unifiedendocrine] https://unifiedendocrinecare.com/ [https://unifiedendocrinecare.com/]https://www.youtube.com/@chhayamakhijamd [https://www.youtube.com/@chhayamakhijamd] https://www.linkedin.com/in/chhayamakhijamd/ [https://www.linkedin.com/in/chhayamakhijamd/] Email: connect@unifiedendocrinecare.com [connect@unifiedendocrinecare.com] Disclaimer: This podcast is for educational, informational, and entertainment purposes only. It’s not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance. 🔔 Don’t forget to like, subscribe, and hit the bell icon!