Can We Upload The Human Brain? - Dr. Randal Koene - #28

Can We Upload The Human Brain? - Dr. Randal Koene - #28

Randal Koene is a Dutch neuroscientist, neuroengineer, and co-founder of the Carboncopies Foundation, a nonprofit advancing research into substrate-independent minds. He holds a Ph.D. in Computational Neuroscience from McGill University and an M.Sc [http://M.Sc]. in Electrical Engineering from Delft University of Technology. Koene coined the term "whole brain emulation" in 2000 and has spent decades building the scientific roadmap for recreating brain function in non-biological substrates. He previously served as a professor at Boston University's Center for Memory and Brain, as Director of Neuroengineering at Tecnalia in Spain, and as Science Director of the 2045 Initiative. In this conversation, he explains how structural brain scanning has advanced dramatically, why the viral fruit fly brain demo was more limited than headlines suggested, and what it would actually take to build and validate an emulation of a human brain. Expect to learn how Randal's father at CERN shaped his thinking about substrate independence, what inspired him to coin the term whole brain emulation, how lesion studies and evolutionary biology support the idea that minds can run on different hardware, what the difference is between neuronal networks and artificial neural networks, how electron microscopy is transforming brain data collection, why the viral fruit fly brain demo was misleading, what the two biggest bottlenecks are in scaling brain emulation to humans, how AI is being used as a tool in computational neuroscience, what consciousness is according to the Metzinger framework, whether a brain emulation would have human rights, how the Carboncopies Foundation's brain emulation challenge works, and why whole brain emulation and mind uploading are not the same thing. Randal Koene online: Website: randalkoene.com [http://randalkoene.com] Carboncopies Foundation: carboncopies.org [http://carboncopies.org] LinkedIn: linkedin.com/in/randalkoene [http://linkedin.com/in/randalkoene] Contact: contact@carboncopies.org [contact@carboncopies.org]

The Science of Decision Making - Gerd Gigerenzer - #27

Gerd Gigerenzer is a German psychologist, director of the Harding Center for Risk Literacy at the University of Potsdam, and director emeritus of the Max Planck Institute for Human Development in Berlin, where he led the Center for Adaptive Behavior and Cognition for over two decades. He is the author of numerous books including Risk Savvy, Gut Feelings, and The Intelligence of Intuition, and has spent his career studying how people actually make decisions under uncertainty, as opposed to how theorists think they should. Before becoming an academic, he spent roughly a dozen years as a professional musician, an experience that directly shaped his thinking about heuristics and real-world choice. His long-running intellectual debate with Nobel laureate Daniel Kahneman over the nature of human rationality is one of the defining controversies in modern behavioral science. Expect to learn how Gigerenzer chose an academic career over life as a professional musician using heuristic rather than calculated reasoning, how the gap between what is taught about rationality in universities and how people actually decide prompted his life's research agenda, what the crucial distinction between risk and uncertainty means and why standard probability tools fail in an uncertain world, how intuition works as a form of unconscious intelligence built on experience rather than arbitrary feeling, why corporate executives routinely hide gut decisions behind consulting reports and what Gigerenzer calls defensive decision making, how predictive AI systems used in US courts fail to outperform simple strategies despite being marketed as superior, what ecological rationality means and how it differs from the logical rationality assumed by most economists and behavioral scientists, why Gigerenzer disagreed with Daniel Kahneman about heuristics and what their decades-long debate was actually about, when ignoring information leads to better decisions than processing all of it, how the framing of medical statistics as relative rather than absolute risk caused thousands of unnecessary procedures in the UK, and what risk literacy means and why Gigerenzer believes it is a necessary condition for a functioning democracy. Gerd Gigerenzer online: Website: www.gerd-gigerenzer.com [http://www.gerd-gigerenzer.com] Books: Risk Savvy, Gut Feelings, The Intelligence of Intuition, How to Stay Smart in a Smart World (available wherever books are sold).

Ozempic, GLP-1s and the Future of Obesity - Prof. Carel Le Roux - #26

Carel le Roux is a Professor of Experimental Pathology at University College Dublin, Director of the Metabolic Medicine Group, and one of the world's leading researchers on how the gut communicates with the brain. He completed his PhD at Imperial College London, where he conducted foundational research on gut hormones and appetite, and later co-founded My Best Weight, Ireland's leading obesity care clinic accredited by the European Association for the Study of Obesity. His clinical work and trials span GLP-1 receptor agonists, bariatric surgery outcomes, and the emerging class of multi-receptor drugs now transforming obesity medicine. He is currently leading the trial of survodutide, one of the most promising next-generation treatments in the field. Expect to learn how GLP-1 was discovered during PhD research into gut-brain communication and how it became one of the most consequential drug classes in medical history, what the Gila monster's saliva has to do with the development of Ozempic and drugs like it, why obesity is a disease of the brain rather than a failure of willpower or lifestyle, how these medications reset the brain's fat-mass setpoint so that weight loss happens without deliberate effort, what ultra-processed foods may be doing to brain inflammation and why reversing the obesity epidemic through diet advice alone has failed everywhere it has been tried, why the goal of treatment should be health gain rather than weight loss and what that distinction means in practice, how to manage and minimise side effects by titrating the dose slowly, what the long-term safety record of GLP-1 drugs actually shows and why not taking the medication is often the riskier choice, why muscle loss on these drugs is largely a misunderstood phenomenon and what protein intake and exercise do to address it, what the evidence says about non-obese people using GLP-1 drugs recreationally and why these treatments were designed as lifelong medications, how GLP-1-like drugs appear to reduce alcohol consumption and are now being studied for addiction and other conditions including heart and kidney disease, and what new triple-receptor drugs like retatrutide and survodutide offer over existing treatments. Carel le Roux online: Website: mybestweight.ie [http://mybestweight.ie] University profile: University College Dublin, Conway Institute of Biomolecular and Biomedical Research

The Science of Awe - Gloria Simoncini - #25

Gloria Simoncini is a neuropsychologist, psychotherapist, and PhD student at eCampus University, Department of Theoretical and Applied Sciences, researching the emotion of awe. She trained clinically in cognitive rehabilitation with patients who had acquired brain injuries, an experience that drew her toward the scientific study of emotions and their role in human transformation. Her doctoral project sits at the intersection of affective neuroscience, virtual reality, and clinical neuropsychology, with a particular focus on using VR environments to screen for mild cognitive impairment in ecologically valid, real-life-like scenarios. She works within a research group on emotions and complex emotional experiences, including awe, positive psychology, and affect dynamics. Expect to learn how awe is formally defined through its two core ingredients of vastness and the need for accommodation, what makes awe distinct from related emotions like wonder, elevation, and fear, why awe is unusually difficult to study in laboratory conditions and how virtual reality helps solve that problem, what happens in the brain during awe including changes in the default mode network and the small self effect, how positive and negative awe recruit different neural structures, what physical responses in the body accompany an awe experience, why the evolutionary negativity bias makes cultivating positive emotions like awe require conscious effort, how awe may function as a therapeutic tool for depression by reducing rumination and loosening rigid mental frameworks, what Gloria's own PhD research on VR-based cognitive screening looks like in practice, and how awe can be trained as a perspective rather than simply waited for as a fleeting moment. Gloria Simoncini online: ResearchGate: https://www.researchgate.net/profile/Gloria-Simoncini [https://www.researchgate.net/profile/Gloria-Simoncini] Research group (Prof. Alice Chirico): https://www.researchgate.net/profile/Alice-Chirico-2 [https://www.researchgate.net/profile/Alice-Chirico-2]

The Future of Meat - Prof. Hanna Tuomisto - #24

Hanna Tuomisto is a professor of sustainable food systems at the University of Helsinki, based in Finland, and one of the world's leading researchers on the environmental impacts of cultivated meat. She earned her PhD in agroecology and sustainable agriculture from the University of Oxford and has been researching cell-culturing technologies for food production since 2008, when she carried out one of the first environmental life cycle assessments of what was then called in vitro meat. She leads the Future Sustainable Food Systems research group at Helsinki and has published extensively on life cycle assessment, carbon footprinting, and the sustainability of novel proteins. In this episode, she walks through the full picture of cultivated meat, from the biology of cell cultivation to the regulatory and economic barriers standing between lab prototypes and supermarket shelves. Expect to learn how the global livestock sector contributes roughly 20% of all human-caused climate impact, what role land use and deforestation play in biodiversity loss driven by animal agriculture, why antibiotic use in livestock poses a growing public health risk, how cultivated meat is produced from a small cell sample to a finished product, what fetal bovine serum is and why replacing it is one of the central technical challenges, how the culture medium feeds cells in the same way feed nourishes a living animal, why the texture of cultivated meat is harder to replicate than its flavor, what the current state of regulatory approval looks like in Europe, Singapore, and the United States, how startup investment outpaced fundamental research and slowed the field's progress, why a supermarket-scale product is likely still 15 to 20 years away, and whether cultivated meat could one day serve as a protein source for long-duration space missions. Hanna Tuomisto online: University of Helsinki: https://www.helsinki.fi/en/researchgroups/future-sustainable-food-systems/people [https://www.helsinki.fi/en/researchgroups/future-sustainable-food-systems/people] ResearchGate: https://www.researchgate.net/profile/Hanna-Tuomisto-2 [https://www.researchgate.net/profile/Hanna-Tuomisto-2] Good Food Institute (cultivated meat research hub): https://gfi.org [https://gfi.org]