Taco Bout Fertility Tuesday

Stop Chasing the Perfect IVF Protocol

16 min · 15. juli 2026
Billede af episoden Stop Chasing the Perfect IVF Protocol

Description

Send us Fan Mail [https://www.buzzsprout.com/621007/fan_mail/new] After a disappointing IVF retrieval, it is tempting to change everything. But does a new protocol actually explain a better next cycle—or is biology doing some of the talking? In this episode, Dr. Mark Amols explains why IVF protocols absolutely matter, but why there is no single “perfect” protocol that can guarantee a certain number of eggs or mature eggs. Using the analogy of an Olympic runner and the right running shoes, he breaks down the physician’s role: optimize the medication plan, timing, trigger, and safety—without pretending we can fully control ovarian biology. Dr. Amols reviews a 2026 Fertility and Sterility study of 801 consecutive IVF cycle pairs showing substantial cycle-to-cycle variation even when patients used the same stimulation protocol and dose. He also discusses why mature eggs matter more than total egg count, when a protocol change is purposeful, and why retrieval and lab workflow can influence the final egg number too. If your last IVF cycle did not go as hoped, this episode will help you ask the better question: not “What can we change?” but “What did we learn, and what are we trying to improve?” Referenced studies: Hochberg et al., Fertility and Sterility (2026); Mutlu et al., Nature Medicine (2026). Thanks for tuning in to another episode of 'Taco Bout Fertility Tuesday' with Dr. Mark Amols. If you found this episode insightful, please share it with friends and family who might benefit from our discussion. Remember, your feedback is invaluable to us – leave us a review on Apple Podcasts, Spotify, or your preferred listening platform. Stay connected with us for updates and fertility tips – follow us on Facebook. For more resources and information, visit our website at www.NewDirectionFertility.com. Have a question or a topic you'd like us to cover? We'd love to hear from you! Reach out to us at TBFT@NewDirectionFertility.com. Join us next Tuesday for more discussions on fertility, where we blend medical expertise with a touch of humor to make complex topics accessible and engaging. Until then, keep the conversation going and remember: understanding your fertility is a journey we're on together.

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244 episodes

episode Is God Punishing Me With Infertility? Faith, Guilt, and What the Bible Says artwork

Is God Punishing Me With Infertility? Faith, Guilt, and What the Bible Says

Send us Fan Mail [https://www.buzzsprout.com/621007/fan_mail/new] Infertility can lead to a painful question that many people are afraid to say aloud: Is God punishing me? In this deeply personal episode of Taco Bout Fertility Tuesday, Dr. Mark Amols explores why infertility can feel like spiritual rejection. When children are described as blessings, pregnancy comes easily to others, and treatment repeatedly fails, it can be tempting to believe that God is angry—or that something from your past made you undeserving of becoming a parent. But does the Bible actually support that conclusion? Drawing from the stories of Hannah, Zechariah and Elizabeth, the teachings of Jesus, and several key passages of Scripture, Dr. Amols examines the difference between feeling punished and having evidence that punishment is occurring. He also discusses how religious comments, self-blame, and the need to find an explanation can add spiritual shame to an already painful medical diagnosis. Infertility is not a spiritual report card. A failed treatment is not proof that you prayed incorrectly, lacked faith, or were found unworthy. Your empty arms are not proof of God’s anger, and your unanswered prayers are not proof that He has forgotten you. Thanks for tuning in to another episode of 'Taco Bout Fertility Tuesday' with Dr. Mark Amols. If you found this episode insightful, please share it with friends and family who might benefit from our discussion. Remember, your feedback is invaluable to us – leave us a review on Apple Podcasts, Spotify, or your preferred listening platform. Stay connected with us for updates and fertility tips – follow us on Facebook. For more resources and information, visit our website at www.NewDirectionFertility.com. Have a question or a topic you'd like us to cover? We'd love to hear from you! Reach out to us at TBFT@NewDirectionFertility.com. Join us next Tuesday for more discussions on fertility, where we blend medical expertise with a touch of humor to make complex topics accessible and engaging. Until then, keep the conversation going and remember: understanding your fertility is a journey we're on together.

22. juli 202622 min
episode Stop Chasing the Perfect IVF Protocol artwork

Stop Chasing the Perfect IVF Protocol

Send us Fan Mail [https://www.buzzsprout.com/621007/fan_mail/new] After a disappointing IVF retrieval, it is tempting to change everything. But does a new protocol actually explain a better next cycle—or is biology doing some of the talking? In this episode, Dr. Mark Amols explains why IVF protocols absolutely matter, but why there is no single “perfect” protocol that can guarantee a certain number of eggs or mature eggs. Using the analogy of an Olympic runner and the right running shoes, he breaks down the physician’s role: optimize the medication plan, timing, trigger, and safety—without pretending we can fully control ovarian biology. Dr. Amols reviews a 2026 Fertility and Sterility study of 801 consecutive IVF cycle pairs showing substantial cycle-to-cycle variation even when patients used the same stimulation protocol and dose. He also discusses why mature eggs matter more than total egg count, when a protocol change is purposeful, and why retrieval and lab workflow can influence the final egg number too. If your last IVF cycle did not go as hoped, this episode will help you ask the better question: not “What can we change?” but “What did we learn, and what are we trying to improve?” Referenced studies: Hochberg et al., Fertility and Sterility (2026); Mutlu et al., Nature Medicine (2026). Thanks for tuning in to another episode of 'Taco Bout Fertility Tuesday' with Dr. Mark Amols. If you found this episode insightful, please share it with friends and family who might benefit from our discussion. Remember, your feedback is invaluable to us – leave us a review on Apple Podcasts, Spotify, or your preferred listening platform. Stay connected with us for updates and fertility tips – follow us on Facebook. For more resources and information, visit our website at www.NewDirectionFertility.com. Have a question or a topic you'd like us to cover? We'd love to hear from you! Reach out to us at TBFT@NewDirectionFertility.com. Join us next Tuesday for more discussions on fertility, where we blend medical expertise with a touch of humor to make complex topics accessible and engaging. Until then, keep the conversation going and remember: understanding your fertility is a journey we're on together.

15. juli 202616 min
episode Pregnant at 50: Miracle, Medicine, or Missing Information? artwork

Pregnant at 50: Miracle, Medicine, or Missing Information?

Send us Fan Mail [https://www.buzzsprout.com/621007/fan_mail/new] Can you actually get pregnant at 50? The headlines never tell you the number that matters most: how old was the egg? In this episode of Taco Bout Fertility Tuesday, Dr. Mark Amols breaks down what is really behind those “pregnant at 50” headlines — and why the same story can mean completely different biology depending on the details nobody reports. In this episode: 🌮 Why there are four biological clocks, not one — egg, uterus, sperm, and parenting 🌮 Real IVF success rates by age, from under 35 through over 42 🌮 How many IVF cycles it may take to reach a high chance of live birth — and why that number is math, not a treatment plan 🌮 The year-by-year live birth data from age 43 to 50+, and why the curve plateaus near the floor in the late 40s 🌮 Why euploid embryos change the odds — but do not erase age completely 🌮 What donor eggs can and cannot fix: they reset the egg clock, not the pregnancy clock 🌮 What we know, and do not fully know, about pregnancy risks after 45 and 50 🌮 Why sperm age matters too, and what advanced paternal age has been linked to 🌮 The uncomfortable conversation about the “parenting clock” that no one wants to have 00:00 Introduction — the headline vs. the real number 02:23 The four biological clocks 04:00 IVF success with your own eggs, by age 06:09 How many cycles to reach an 85% cumulative chance 08:44 Year-by-year data: age 43 through 50+ 12:59 Pregnancy vs. live birth — why miscarriage risk rises 14:38 Euploid embryos and what PGT-A does, and does not, fix 17:52 The blastocyst math — why “8 eggs” is not what it sounds like 20:23 Donor eggs: what they reset, and what they do not 21:49 Pregnancy risks after 45 and 50 23:09 Sperm age and paternal risk 23:40 The parenting clock 24:46 Key takeaways 26:44 Closing If you found this episode helpful, share it with someone who needs the real numbers behind later-age pregnancy headlines. Subscribe so you do not miss next week’s episode, and drop your questions in the comments — Dr. Amols reads them all. Thanks for tuning in to another episode of 'Taco Bout Fertility Tuesday' with Dr. Mark Amols. If you found this episode insightful, please share it with friends and family who might benefit from our discussion. Remember, your feedback is invaluable to us – leave us a review on Apple Podcasts, Spotify, or your preferred listening platform. Stay connected with us for updates and fertility tips – follow us on Facebook. For more resources and information, visit our website at www.NewDirectionFertility.com. Have a question or a topic you'd like us to cover? We'd love to hear from you! Reach out to us at TBFT@NewDirectionFertility.com. Join us next Tuesday for more discussions on fertility, where we blend medical expertise with a touch of humor to make complex topics accessible and engaging. Until then, keep the conversation going and remember: understanding your fertility is a journey we're on together.

8. juli 202627 min
episode The Ovary’s Side of the Story: Menstrual Cycle Myths Explained artwork

The Ovary’s Side of the Story: Menstrual Cycle Myths Explained

Send us Fan Mail [https://www.buzzsprout.com/621007/fan_mail/new] Most people think of the menstrual cycle as bleeding, cramps, cycle day one, or an app prediction. But the period is really the final report — not the main event. In this episode of Taco Bout Fertility Tuesday, Dr. Mark Amols explains the menstrual cycle from the ovary’s point of view. Learn how the brain, ovary, and uterus communicate each month, why one follicle becomes dominant, why IVF does not “use up” future eggs, and why so many common menstrual-cycle myths fall apart once you understand the science. We cover myths like whether ovaries take turns, whether one ovary means ovulating every other month, whether bleeding always means ovulation, whether cycle apps really know when you ovulate, and whether everyone needs to wait three months after a miscarriage before trying again. The menstrual cycle is not a calendar, an app prediction, or a right-left ovary schedule. It is a hormone conversation between the brain, ovary, and uterus. Thanks for tuning in to another episode of 'Taco Bout Fertility Tuesday' with Dr. Mark Amols. If you found this episode insightful, please share it with friends and family who might benefit from our discussion. Remember, your feedback is invaluable to us – leave us a review on Apple Podcasts, Spotify, or your preferred listening platform. Stay connected with us for updates and fertility tips – follow us on Facebook. For more resources and information, visit our website at www.NewDirectionFertility.com. Have a question or a topic you'd like us to cover? We'd love to hear from you! Reach out to us at TBFT@NewDirectionFertility.com. Join us next Tuesday for more discussions on fertility, where we blend medical expertise with a touch of humor to make complex topics accessible and engaging. Until then, keep the conversation going and remember: understanding your fertility is a journey we're on together.

1. juli 202619 min
episode Progesterone Shots: Are Fertility Doctors Sadists or Just Following the Science? artwork

Progesterone Shots: Are Fertility Doctors Sadists or Just Following the Science?

Send us Fan Mail [https://www.buzzsprout.com/621007/fan_mail/new] Progesterone-in-oil shots, also known as PIO shots, are one of the most feared and hated parts of IVF. They are uncomfortable, intimidating, and often leave patients wondering: “Do I really need this, or is my fertility doctor just being cruel?” In this episode of Taco Bout Fertility Tuesday, Dr. Mark Amols explains why progesterone matters for implantation, how estrogen and progesterone work together to prepare the uterine lining, and why the type of embryo transfer cycle changes everything. The key question is not simply whether progesterone shots are better than vaginal progesterone. The real question is whether your body is making progesterone on its own. Dr. Amols breaks down the difference between ovulatory or modified natural frozen embryo transfers and programmed frozen embryo transfers. In an ovulatory cycle, the body forms a corpus luteum and produces progesterone naturally. In a programmed cycle, there is no ovulation, no corpus luteum, and therefore no natural progesterone production — meaning all progesterone support must come from medication. This episode also reviews the research comparing daily progesterone-in-oil shots, vaginal progesterone alone, and combination protocols using vaginal progesterone plus intermittent PIO injections. The data shows why vaginal progesterone alone may not be enough in programmed frozen embryo transfer cycles and why many clinics still rely on PIO for reliable progesterone support. Dr. Amols also discusses progesterone blood levels, why levels can be hard to interpret with vaginal progesterone, why clinics may differ in their protocols, and how some patients may be candidates for fewer injections or modified natural cycles. If you are preparing for an embryo transfer, taking progesterone, or wondering why your clinic recommends PIO shots, this episode will help you understand the science behind the shot — and hopefully hate your doctor a little less. The bottom line: fertility doctors are not sadists. Progesterone-in-oil may be a literal pain in the butt, but in some embryo transfer cycles, it has an important purpose. Thanks for tuning in to another episode of 'Taco Bout Fertility Tuesday' with Dr. Mark Amols. If you found this episode insightful, please share it with friends and family who might benefit from our discussion. Remember, your feedback is invaluable to us – leave us a review on Apple Podcasts, Spotify, or your preferred listening platform. Stay connected with us for updates and fertility tips – follow us on Facebook. For more resources and information, visit our website at www.NewDirectionFertility.com. Have a question or a topic you'd like us to cover? We'd love to hear from you! Reach out to us at TBFT@NewDirectionFertility.com. Join us next Tuesday for more discussions on fertility, where we blend medical expertise with a touch of humor to make complex topics accessible and engaging. Until then, keep the conversation going and remember: understanding your fertility is a journey we're on together.

24. juni 202617 min