THE ARTIFACT: True Stories of Fraud, Ego, and the Lies We Call Fact
We want to believe that science is a pure pursuit of truth and that the world's elite researchers are infallible. But in the world of high-stakes academic and corporate drug discovery, bringing back negative data can mean career death. In Part 1 of "The Teflon President", we trace the meteoric rise and hidden cracks in the academic empire of Dr. Marc Tessier-Lavigne. A former Rhodes Scholar who revolutionized neuroscience with the discovery of axonal guidepost proteins called "netrins", Tessier-Lavigne built a reputation that carried him from UCSF and Stanford to the highest executive ranks of Genentech, where he oversaw 1,400 scientists. However, behind closed glass doors, his laboratories operated under a high-pressure "Ghost CEO" management style. An investigation would later reveal a brutal caste system that rewarded "winners" who brought back clean, blockbuster data and marginalized "losers" whose experiments were messy. When biology refused to provide perfection, researchers turned to Adobe Photoshop. What You’ll Hear in Part 1: The Prodigy’s Gamble: How a physicist-turned-neuroscientist processed 25,000 embryonic chick brains to discover netrins. The "Winners vs. Losers" Dynamic: The toxic laboratory culture that incentivized postdocs to alter Western blot images to survive. The Case of Elke Stein: The star researcher whose experiments worked "too perfectly, every time", her doctored 1999 and 2001 papers, and her strange later years. The Alzheimer’s "Miracle" & The Reagent Trap: How a 2009 *Nature* paper on Death Receptor 6 (DR6) claimed to find the "kill switch" for Alzheimer's, used to boost Genentech’s $4 billion acquisition price by Roche, before internal scientists caught lead author Anatoly Nikolaev in a secret reagent-swap trap. The Secret 2010 Purge: The hidden corporate firing of another postdoc that Genentech kept from the public eye. If you enjoyed Part 1, subscribe to or follow us on Apple Podcasts, Spotify, or your favorite player so you don't miss Part 2: The Billion-Dollar Comeback, where an 18-year-old freshman reporter takes on the President of Stanford University.
11 episodes
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