The Elevated Dose Podcast

Episode 10: PCOS Isn’t a Weight Problem: Insulin Signaling, GLP-1s, and What the Evidence Actually Shows

39 min · 9. feb. 2026
episode Episode 10: PCOS Isn’t a Weight Problem: Insulin Signaling, GLP-1s, and What the Evidence Actually Shows cover

Description

PCOS is not a willpower problem, it’s a signaling problem. In this deep dive, I break down the insulin-androgen loop that makes PCOS feel like you’re doing everything “right” and still getting nowhere, then walks through what clinical trials and meta-analyses suggest about GLP-1 therapies (liraglutide, exenatide, semaglutide) for metabolic and reproductive outcomes. We also cover what’s currently being studied in ongoing trials. If you want trusted GLP-1 care with access to registered dietitians, you can find my recommended resources at www.theelevateddose.com. Subscribe to The Elevated Dose for conversations about GLP-1s, metabolic health, and long-term success without diet culture. And if this episode helped, leaving a 5-star review helps more people find it.

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episode Episode 10: PCOS Isn’t a Weight Problem: Insulin Signaling, GLP-1s, and What the Evidence Actually Shows artwork

Episode 10: PCOS Isn’t a Weight Problem: Insulin Signaling, GLP-1s, and What the Evidence Actually Shows

PCOS is not a willpower problem, it’s a signaling problem. In this deep dive, I break down the insulin-androgen loop that makes PCOS feel like you’re doing everything “right” and still getting nowhere, then walks through what clinical trials and meta-analyses suggest about GLP-1 therapies (liraglutide, exenatide, semaglutide) for metabolic and reproductive outcomes. We also cover what’s currently being studied in ongoing trials. If you want trusted GLP-1 care with access to registered dietitians, you can find my recommended resources at www.theelevateddose.com. Subscribe to The Elevated Dose for conversations about GLP-1s, metabolic health, and long-term success without diet culture. And if this episode helped, leaving a 5-star review helps more people find it.

9. feb. 202639 min