The John & Calvin Podcast

Does saturated fat cause heart attacks?

Does cutting saturated fat actually prevent heart attacks?For decades, saturated fat from foods like butter, red meat, cheese, coconut oil, and full-fat dairy has been treated as something to reduce. But the new USDA/HHS dietary guidelines and the inverted food pyramid have made the message a lot less clear.In this episode, Calvin and John look closely at two 2025 meta analyses of randomized controlled trials: Yamada 2025 and Steen 2025. One says there is no clear benefit to reducing saturated fat. The other says there may be a benefit, but mostly depending on your cardiovascular risk and what you replace saturated fat with.We don’t just read the abstracts. We go deep into the studies, recreate some of the charts, check the reported metrics, look at the forest plots, compare odds ratios and risk ratios, and dig into where the conclusions seem strong, weak, or a little too confident.Hopefully, there’s also something useful here about how to think through studies, evidence, and nutrition claims when the answer is not as clean as it first seems.

How We Die: An Interactive Mortality Explorer

In this episode, we look at how Americans die at different ages using U.S. mortality data from the CDC. John walks through an interactive mortality data tool he built with multiple interactive charts showing broad causes of death by overall rank, age at death, and over time, along with detailed subcauses.The charts have filters for sex, age range, time period, and metric. We discuss the patterns that stand out and why the tool is useful.

Does Tylenol Cause Autism?

A recent government announcement claimed Tylenol use during pregnancy causes autism, sparking widespread concern. We dissect the controversial study behind this claim, uncovering major flaws and conflicts of interest, and reveal what higher-quality evidence actually says about the risk.

Is Fatty15 a SCAM?

Critical analysis of the popular anti-aging supplement fatty15, dissecting its "science-backed" claims and deceptive marketing tactics.Is fatty15 a “new essential fatty acid” that’s “3× better than omega-3”?Is fatty15 GRAS "certified'?Does fatty15 have any health benefits in humans?We review the evidence, including all the human randomized controlled trials on fatty15.Slides: https://www.jsdatascience.com/fatty15/

KETO-CTA study: Data Published... It's WORSE than we thought!

In this episode, we revisit the controversial Keto-CTA study about cholesterol, and arterial plaque progression. After the authors released some of their raw data, our analysis reveals the study's flaws are far worse than first thought. John breaks down the egregious errors, from published charts that incorrectly cut plaque progression in half, to statistical models that violate their own assumptions, directly contradicting the authors' claims and invalidating their conclusions.