The Pauling Principle

The Pauling Principle Episode 27 - Longevity Medicine with Andrea Maier

Most doctors treat you after you get sick. Professor Andrea Maier is trying to make sure you never get there. In this episode, I sit down with one of the world's leading longevity scientists, a biogerontologist who holds professorships across three continents, founded the Healthy Longevity Medicine Society, and co-founded Chi Longevity Clinics in Singapore. We explore why aging itself is becoming a treatable condition, how biological aging clocks are changing the way we think about health, and what it actually takes to bring longevity medicine out of luxury clinics and into everyday practice. This is a conversation about the science, the clinical reality, and the future of growing older on your own terms.

The Pauling Principle Episode 29 - Targeting the pathological cells that drive aging

In this episode of The Pauling Principle I sit with Marco Quarta, Founder and current CSO of Rubedo and we discuss cellular senescence, one of the most prominent causes of aging, and a variety of potential therapies. As well as Rubedo recent positive phase I clinical trial.

The Pauling Principle Episode 26 - How do you simulate a molecule that won't sit still?

In this episode I sit down with Professor Hugo Verli, one of the pioneers in computational chemistry. And we discuss the past, present, and future of the field. Including some of the key challenges, like how to simulate carbohydrates and highly dynamic molecules. What simulations would YOU like to run? let me know in the comments! :)

The Pauling Principle Episode 25 - How to design RNA (and the origin of life)

Designing functional RNA for therapeutics is notoriously hard, but gRNAde changes the game. This geometric deep learning model generates high quality RNA sequences from target 3D structures. It outperforms Rosetta, slashes design time to seconds, and hits 50% success in wet-lab tests on complex folds. Chaitanya Joshi, lead author of the paper, joins us to share how gRNAde is speeding up RNA-based medicines and programmable biology.

The Pauling Principle Episode 24 - Longevity with Aubrey de Grey

What if aging itself is the disease we should be curing? In this episode, I sit down with Aubrey de Grey, the legendary biogerontologist who has spent decades arguing that aging is not an inevitable fate but an engineering problem with solvable components. We dive into the science behind his SENS framework, explore why the longevity field is finally gaining mainstream momentum, and debate just how close we are to adding decades of healthy life to the human lifespan. Whether you're a skeptic or a true believer, this conversation will challenge how you think about mortality, medicine, and what it means to grow old. Aubrey is also someone that I admire deeply, so I hope you find this conversation interesting!