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This Week in Cardiology
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This podcast delivers Dr. John Mandrola’s summary and perspective on top news of the week that cardiologists can’t miss. This podcast is intended for US health professionals only.
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308 episodesMay 03 2024 This Week in Cardiology
The DEDICATE trial of TAVR vs SAVR, more on renal denervation, inclisiran, and marketing disguised as science are the topics John Mandrola, MD, discusses in today’s podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. TAVR vs SAVR
TAVI Comparable With SAVR in Lower-Risk Aortic Stenosis
https://www.medscape.com/viewarticle/tavi-comparable-savr-lower-risk-aortic-stenosis-2024a100074o?form=fpf
* DEDICATE https://www.nejm.org/doi/full/10.1056/NEJMoa2400685
* Partner 3 https://www.nejm.org/doi/full/10.1056/NEJMoa1814052
* Evolut Low Risk https://www.nejm.org/doi/full/10.1056/NEJMoa1816885
* Barili meta-analysis https://doi.org/10.1093/ejcts/ezab516
II. Renal Denervation
Alcohol-Mediated Renal Denervation Promising in Hypertension
https://www.medscape.com/viewarticle/alcohol-mediated-renal-denervation-promising-hypertension-2024a10007eg
* TARGET 1 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.069291
III. Inclisiran
Earlier Inclisiran Gives Better Long-Term LDL Reductions
https://www.medscape.com/viewarticle/earlier-inclisiran-gives-better-long-term-ldl-reductions-2024a10007d6
* VICTORIAN INITIATE Trial https://www.jacc.org/doi/10.1016/j.jacc.2024.03.382
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Questions or feedback, please contact news@medscape.net
Yesterday - 20 min
Apr 26 2024 This Week in Cardiology
A listener defends colored boxes in guidelines; mysteries of non-culprit coronary lesions during PCI, and of AF ablation; and surrogate markers are the topics John Mandrola, MD, covers in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Mystery of What to Do in the Cath Lab after Fixing the Culprit Lesion – The FULL REVASC Trial
Complete Revascularization Not Superior to Culprit-Only PCI After MI
https://www.medscape.com/viewarticle/complete-revascularization-not-superior-culprit-only-pci-2024a10007ik
* FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149
* FIRE Trial https://www.nejm.org/doi/10.1056/NEJMoa2300468
* COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775
* Cohen Tweet on FULL REVASC https://x.com/djc795/status/1781361606238085532
II. AF Ablation Mysteries
New Expert Consensus on Ablation Strategies for AF
https://www.medscape.com/viewarticle/new-expert-consensus-ablation-strategies-af-2024a1000851
* Bern Study of Remapping https://doi.org/10.1016/j.jacep.2024.02.026
* Natural History of SCAF https://doi.org/10.1016/j.jacc.2019.09.050
* Liverpool Study: Thermal PV Isolation in Persistent AF https://doi.org/10.1016/j.hrthm.2024.04.061
III. Surrogate Markers
* JAMA: Surrugate Markers and Clinical Outcomes https://jamanetwork.com/journals/jama/fullarticle/2817850
* BP Surrogate Meta-analysis https://doi.org/10.1016/S0140-6736(21)00590-0
* JAMA: Nonfatal MI as Surrogate for Mortality https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2785560
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
26. apr. 2024 - 28 min
Apr 19 2024 This Week in Cardiology
ACC Part 2: The TACT2 trial of chelation, inter-atrial shunts for HF, and triglyceride lowering; plus diltiazem and Factor Xa anticoagulants are the topics John Mandrola, MD, covers this week.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. TACT 2
Chelation Therapy Provides No Benefit Post-MI
https://www.medscape.com/viewarticle/chelation-therapy-provides-no-benefit-post-mi-2024a10006l5
Chelation Therapy and CV Risk: Why TACT2 Showed No Benefit https://www.medscape.com/viewarticle/chelation-therapy-and-cv-risk-why-tact2-showed-no-benefit-2024a1000761?src=
* JAMA TACT 1 paper https://jamanetwork.com/journals/jama/fullarticle/1672238
* Diabetes Subgroup paper https://pubmed.ncbi.nlm.nih.gov/24254885/
* A New Look at P-values https://evidence.nejm.org/doi/abs/10.1056/EVIDoa2300003
* PARAGON HF https://www.nejm.org/doi/full/10.1056/NEJMoa1908655
II. Interatrial Shunts for HF
No Net HF Benefit for Interarterial Shunt Device
https://www.medscape.com/viewarticle/no-net-hf-benefit-interarterial-shunt-device-2024a10006kk
* REDUCE LAP HF II https://doi.org/10.1016/S0140-6736(22)00016-2
III. Triglyceride Lowering
Early Olezarsen Results Show 50% Reduction in Triglycerides
https://www.medscape.com/viewarticle/early-olezarsen-results-show-50-reduction-triglycerides-2024a10006oz
Is It Time to Stop Treating High Triglycerides?
https://www.medscape.com/viewarticle/990126
* NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2402309
Substantial Triglyceride Reduction With Plozasiran
https://www.medscape.com/viewarticle/substantial-triglyceride-reduction-plozasiran-2024a10006wf?icd=login_success_email_match_norm
* JAMA Cardiology https://jamanetwork.com/journals/jamacardiology/article-abstract/2817469
IV. Diltiazem and Factor Xa inhibitors
* JAMA Vanderbilt University Paper https://jamanetwork.com/journals/jama/fullarticle/2817546
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
19. apr. 2024 - 28 min
Apr 12 2024 This Week in Cardiology
ACC Recap #1: DanGer Shock (plus a sobering JAMA research letter on Impella use), REDUCE-AMI, PREVENT, and EMPACT-MI are the topics John Mandrola, MD, covers in this week’s podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. DanGer-Shock Trial
Impella CP Improves Survival in STEMI, Cardiogenic Shock https://www.medscape.com/viewarticle/impella-cp-improves-survival-stemi-cardiogenic-shock-2024a10006kz
Impella Saves Lives in Cardiogenic Shock, but Patient Selection Key https://www.medscape.com/viewarticle/1000659
* Published DanGer Shock Study https://www.nejm.org/doi/full/10.1056/NEJMoa2312572
* JAMA Research letter https://jamanetwork.com/journals/jama/article-abstract/2817457
II. REDUCE-AMI Trial
New Data Question Beta-Blockers Post-MI With Preserved EF https://www.medscape.com/viewarticle/new-data-question-beta-blockers-post-mi-preserved-ef-2024a10006y8
Beta-Blockers Post-MI Past Their Expiration Date: REDUCE-AMI https://www.medscape.com/viewarticle/1000663
* REDUCE-AMI paper https://www.nejm.org/doi/full/10.1056/NEJMoa2401479
* Meta-analysis: Beta Blockers for MI https://doi.org/10.1016/j.amjmed.2014.05.032
III. PREVENT Trial
Preventive PCI for Vulnerable Plaques Reduces Cardiac Events
https://www.medscape.com/viewarticle/preventive-pci-vulnerable-plaques-reduces-cardiac-events-2024a10006tc
Preventive Coronary Stents: Not There Yet
https://www.medscape.com/viewarticle/preventive-coronary-stents-not-there-yet-2024a10006yr
* PREVENT https://doi.org/10.1016/S0140-6736(24)00413-6
IV. EMPACT MI trial of Empagliflozin in the Post-MI setting
Empagliflozin Fails to Reduce Events After Acute MI
https://www.medscape.com/viewarticle/empagliflozin-fails-reduce-events-after-acute-mi-2024a10006kn
* EMPACT-MI: Another SGLT2 Inhibitor Miss in Post-MI Care https://www.medscape.com/viewarticle/1000684
* EMPACT MI https://www.nejm.org/doi/10.1056/NEJMoa2314051
* DAPA MI https://evidence.nejm.org/doi/full/10.1056/EVIDoa2300286
* PARADISE MI https://www.nejm.org/doi/full/10.1056/NEJMoa2104508
* Kaul thread https://x.com/kaulcsmc/status/1776611935842165029
* Kaul paper https://www.ahajournals.org/doi/full/10.1161/circulationaha.116.022537
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
12. apr. 2024 - 29 min
Apr 05 2024 This Week in Cardiology
Statins and diabetes, AAD in patients with heart disease, tricuspid valve interventions, and an ACC preview are the topics John Mandrola, MD, discusses in this week’s podcast.This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Statins and Diabetes
* Meta-analysis in Lancet-Diabetes https://doi.org/10.1016/S2213-8587(24)00040-8
* Editorial https://doi.org/10.1016/S2213-8587(24)00059-7
* NEJM Paper on Gene Variants and DM https://www.nejm.org/doi/full/10.1056/nejmoa1604304
* JAMA Paper on Gene Variants and DM https://jamanetwork.com/journals/jama/fullarticle/2565289
II. Anti-arrhythmic Drugs in Patients With Serious Heart Disease
* UPenn Paper on AADs for PVC Suppression https://doi.org/10.1016/j.jacep.2024.01.021
* Three Questions for Evidence-Based Cardiac EP https://www.ahajournals.org/doi/full/10.1161/circoutcomes.110.957381
* CAST trial https://www.nejm.org/doi/full/10.1056/NEJM199103213241201
III. Tricuspid Valve Interventions
FDA Clears TriClip for Tricuspid Regurgitation
https://www.medscape.com/viewarticle/fda-clears-triclip-tricuspid-regurgitation-2024a100068o
FDA Panel in Favor of TriClip for Tricuspid Regurgitation
https://www.medscape.com/viewarticle/fda-panel-favor-triclip-tricuspid-regurgitation-2024a100037n
* Slides for Trisend II
* TRILUMINATE https://www.nejm.org/doi/full/10.1056/NEJMoa2300525
IV. ACC Preview
Mandrola's Three Trials to Look for at the 2024 American College of Cardiology Scientific Sessions
https://www.medscape.com/viewarticle/1000613
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
05. apr. 2024 - 26 min
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