Dementia Matters

Training for Clinical Trials with the IMPACT-AD Program

Are you a researcher interested in getting involved in Alzheimer’s disease and related dementias (ADRD) clinical trials? The Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD, or IMPACT-AD, program brings investigators from around the world together for a week of professional development and education. IMPACT-AD co-directors Dr. Josh Grill and Dr. Rema Raman, as well as faculty member Dr. Maria Carrillo, join the podcast to explain what the program entails, their mission and more. Guests: Josh Grill, PhD, director, Institute for Memory Impairments and Neurological Disorders, professor, University of California, Irvine (UCI), co-director, IMPACT-AD, Rema Raman, PhD, co-director, IMPACT-AD, director, Biostatistics Section and Recruitment, Engagement, and Retention Section, Alzheimer’s Therapeutic Research Institute (ATRI), professor of neurology, University of Southern California (USC), and Maria Carrillo, PhD, chief science officer, medical affairs lead, Alzheimer’s Association, co-principal investigator, Alzheimer’s Network for Treatment and Diagnostics (ALZ-NET), co-principal investigator, Longitudinal Early-Onset Alzheimer’s Disease Study (LEADS) Show Notes Learn more and apply for the 2026 IMPACT-AD program on their website [http://impact-ad.org].  Listen to our previous episode with Rema Raman, “Making an IMPACT: Advancing Alzheimer’s Disease Clinical Trials Through Workforce Development and Inclusivity,” [http://adrc.wisc.edu/dementia-matters/making-impact-advancing-alzheimers-disease-clinical-trials-through-workforce] on our website, Spotify [https://open.spotify.com/episode/0gO57Yw6b2aFKY8yHYwBCC?si=b27a35d1d7694d65], Apple Podcasts [https://podcasts.apple.com/us/podcast/making-an-impact-advancing-alzheimers-disease/id1292353638?i=1000653677212] and wherever you listen. Listen to our previous episodes with Josh Grill, “The Case for Disclosing Biomarker Results to Alzheimer’s Research Participants” [https://www.adrc.wisc.edu/dementia-matters/case-disclosing-biomarker-results-alzheimers-research-participants] and “Improving Registries and Representation in Alzheimer’s Disease Research” [https://www.adrc.wisc.edu/dementia-matters/improving-registries-and-representation-alzheimers-disease-research] on our website. Read more about Dr. Raman in her USC Keck School of Medicine Profile [https://keck.usc.edu/faculty-search/rema-raman/]. Read more about Dr. Grill in his UCI faculty profile [https://www.faculty.uci.edu/profile/?facultyId=6201]. Read more about Dr. Carrillo on the Alzheimer’s Association website [https://www.alz.org/press/spokespeople/maria_c_carrillo_ph_d].  Connect with us Find transcripts and more at our website [https://www.adrc.wisc.edu/dementia-matters]. Email Dementia Matters [dementiamatters@medicine.wisc.edu]: dementiamatters@medicine.wisc.edu Follow us on Facebook [https://www.facebook.com/wisconsinadrc] and Twitter [https://twitter.com/WisconsinADRC]. Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter [https://www.adrc.wisc.edu/newsletter]. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s [https://supportuw.org/giveto/dementiamatters]. All donations go toward outreach and production. Learn about and pre-order Dr. Chin’s book, When Memory Fades: What to Expect at Every Stage, from Early Signs to Full Support for Alzheimer's and Dementia [https://read.macmillan.com/lp/when-memory-fades-9781250400857/], out June 2, 2026.

How Ultra‑Processed Foods Impact Your Overall Health

Ultra-processed foods are a hot topic in the fields of health and nutrition, but what exactly are they and how do they impact our overall well-being? Dr. Beth Olson joins the podcast to explain what this term means, describe strategies for developing a balanced diet and share a preview of her upcoming Healthy Living with Mild Cognitive Impairment (MCI) presentation, “Unpacking Ultra-Processed Foods.” Guest: Beth Olson, PhD, associate professor of nutritional sciences, University of Wisconsin–Madison Show Notes Register and learn more about the upcoming Healthy Living with MCI event featuring Dr. Olson, happening on March 6, 2026, and future programs on our website [https://www.adrc.wisc.edu/mci]. Learn more about Dr. Olson on her profile on the UW Department of Nutritional Sciences website [https://nutrisci.wisc.edu/beth-olson/]. Connect with us Find transcripts and more at our website [https://www.adrc.wisc.edu/dementia-matters]. Email Dementia Matters [dementiamatters@medicine.wisc.edu]: dementiamatters@medicine.wisc.edu Follow us on Facebook [https://www.facebook.com/wisconsinadrc] and Twitter [https://twitter.com/WisconsinADRC]. Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter [https://www.adrc.wisc.edu/newsletter]. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s [https://supportuw.org/giveto/dementiamatters]. All donations go toward outreach and production. Learn about and pre-order Dr. Chin’s book, When Memory Fades: What to Expect at Every Stage, from Early Signs to Full Support for Alzheimer's and Dementia [https://read.macmillan.com/lp/when-memory-fades-9781250400857/], out June 2, 2026.

On the Pulse: How Resting Heart Rate Improves a Dementia Risk Score’s Accuracy

What if your heartbeat could help determine your dementia risk? The CAIDE dementia risk score has long helped clinicians estimate midlife risk for dementia using cardiovascular health factors, but its accuracy hasn’t been equal across populations. New research suggests that integrating resting heart rate meaningfully improves predictive performance across most racial groups. In this interview, Dr. Newman Sze and Shakiru Alaka join us to dig into how and why resting heart rate enhances CAIDE’s accuracy, what the data shows across different racial groups, and what this could mean for earlier, more equitable identification of dementia risk in both research and clinical settings. Guests: Newman Sze, PhD, professor of health sciences, Brock University, Canada Research Chair in Mechanisms of Health and Disease, and Shakiru Alaka, MS, senior analyst, Canadian Institute for Health Information, data scientist, Western University Show Notes Read Shakiru and Dr. Sze’s study, “Enhancing the validity of CAIDE dementia risk scores with resting heart rate and machine learning: An analysis from the National Alzheimer's Coordinating Center across all races/ethnicities [https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70442],” published in Alzheimer’s & Dementia online. Learn more about Shakiru and Dr. Sze’s research from this article on the Brock University website [https://brocku.ca/brock-news/2025/08/brock-led-research-drives-breakthrough-in-predicting-dementia-risk/]. Learn more about Dr. Sze and his research from his bio on the Brock University website [https://brocku.ca/applied-health-sciences/health-sciences/faculty-research/faculty-directory/newman-sze/]. Look into more of Shakiru’s research from his Google Scholar page [https://scholar.google.com/citations?user=6oKI8WwAAAAJ&hl=en]. Connect with us Find transcripts and more at our website [https://www.adrc.wisc.edu/dementia-matters]. Email Dementia Matters [dementiamatters@medicine.wisc.edu]: dementiamatters@medicine.wisc.edu Follow us on Facebook [https://www.facebook.com/wisconsinadrc] and Twitter [https://twitter.com/WisconsinADRC]. Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter [https://www.adrc.wisc.edu/newsletter]. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s [https://supportuw.org/giveto/dementiamatters]. All donations go toward outreach and production. Learn about and pre-order Dr. Chin’s book, When Memory Fades: What to Expect at Every Stage, from Early Signs to Full Support for Alzheimer's and Dementia [https://read.macmillan.com/lp/when-memory-fades-9781250400857/], out June 2, 2026.

On the Pulse: How Resting Heart Rate Improves a Dementia Risk Score’s Accuracy

What if one of the most powerful clues about dementia risk is already being captured every morning before you even get out of bed? The CAIDE dementia risk score has long helped clinicians estimate midlife risk for dementia using cardiovascular health factors, but its accuracy hasn’t been equal across populations. New research suggests that integrating resting heart rate meaningfully improves predictive performance across most racial groups. In this interview, Dr. Newman Sze and Shakiru Alaka join us to dig into how and why resting heart rate enhances CAIDE’s accuracy, what the data shows across different racial groups, and what this could mean for earlier, more equitable identification of dementia risk in both research and clinical settings. Guests: Newman Sze, PhD, professor of health sciences, Brock University, Canada Research Chair in Mechanisms of Health and Disease, and Shakiru Alaka, MS, senior analyst, Canadian Institute for Health Information, data scientist, Western University   Show Notes Read Shakiru and Dr. Sze’s study, “Enhancing the validity of CAIDE dementia risk scores with resting heart rate and machine learning: An analysis from the National Alzheimer's Coordinating Center across all races/ethnicities [https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70442],” published in Alzheimer’s & Dementia online. Learn more about Shakiru and Dr. Sze’s research from this article on the Brock University website [https://brocku.ca/brock-news/2025/08/brock-led-research-drives-breakthrough-in-predicting-dementia-risk/]. Learn more about Dr. Sze and his research from his bio on the Brock University website [https://brocku.ca/applied-health-sciences/health-sciences/faculty-research/faculty-directory/newman-sze/]. Look into more of Shakiru’s research from his Google Scholar page [https://scholar.google.com/citations?user=6oKI8WwAAAAJ&hl=en]. Connect with us Find transcripts and more at our website [https://www.adrc.wisc.edu/dementia-matters]. Email Dementia Matters [dementiamatters@medicine.wisc.edu]: dementiamatters@medicine.wisc.edu Follow us on Facebook [https://www.facebook.com/wisconsinadrc] and Twitter [https://twitter.com/WisconsinADRC]. Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter [https://www.adrc.wisc.edu/newsletter]. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s [https://supportuw.org/giveto/dementiamatters]. All donations go toward outreach and production. Learn about and pre-order Dr. Chin’s book, When Memory Fades: What to Expect at Every Stage, from Early Signs to Full Support for Alzheimer's and Dementia [https://bookshop.org/p/books/when-memory-fades-what-to-expect-at-every-stage-from-early-signs-to-full-support-for-alzheimer-s-and-dementia-nathaniel-chin-m-d/65c8e16190fd6721?ean=9781250400857&next=t], out June 2, 2026.

Could Managing Four Common Health Conditions Slow Cognitive Decline from Alzheimer’s?

Alzheimer’s disease isn’t always the only health condition a person faces, so how does treating other diseases impact the progression of Alzheimer’s? Researchers at the University of Arizona focused on four common health conditions – type two diabetes, hypertension, inflammation and dyslipidemia – which are known to increase the risk of developing Alzheimer’s disease, and set out to investigate whether those diagnosed with Alzheimer’s who received treatments for these four conditions also saw a delay in cognitive decline. Dr. Barb Bendlin joins the podcast to break down the findings from this research, as well as discuss the impact of personalized prevention strategies and combination therapies. Guest: Barbara Bendlin, PhD, professor, Division of Geriatrics and Gerontology, University of Wisconsin (UW) School of Medicine and Public Health, deputy director, UW Center for Health Disparities Research (CHDR) Show Notes Read the study, “Combination therapy targeting Alzheimer's disease risk factors is associated with a significant delay in Alzheimer's disease–related cognitive decline [https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.70074],” published by Alzheimer's & Dementia: Translational Research & Clinical Interventions on the Alzheimer’s Association’s website.  Read more about the study in the article “Four Key Pieces Managing Common Health Conditions Slows Alzheimer's Progression [https://www.naccdata.org/nacc-navigator/four-key-pieces-managing-common-health-conditions-slows-alzheimers-progression/],” published on the National Alzheimer’s Coordinating Center’s website. Learn more about Dr. Bendlin from her profile on the UW Center for Health Disparities Research website [https://chdr.wisc.edu/staff/bendlin-barbara/]. Connect with us Find transcripts and more at our website [https://www.adrc.wisc.edu/dementia-matters]. Email Dementia Matters [dementiamatters@medicine.wisc.edu]: dementiamatters@medicine.wisc.edu Follow us on Facebook [https://www.facebook.com/wisconsinadrc] and Twitter [https://twitter.com/WisconsinADRC]. Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter [https://www.adrc.wisc.edu/newsletter]. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s [https://supportuw.org/giveto/dementiamatters]. All donations go toward outreach and production. Learn about and pre-order Dr. Chin’s book, When Memory Fades: What to Expect at Every Stage, from Early Signs to Full Support for Alzheimer's and Dementia [https://read.macmillan.com/lp/when-memory-fades-9781250400857/], out June 2, 2026.