Better Off with Victoria Reynolds
Better Off Daily-13— GLP-1s + Hormones: The Combo That Changes Everything New research confirms what we've been doing in the clinic for years: hormone optimization alongside GLP-1 therapy produces meaningfully better weight loss outcomes. Here's what the data shows — and what it means for your protocol. Research referenced in this episode: * Castaneda R, et al. Tirzepatide + hormone therapy in postmenopausal women — presented at The Menopause Society 2025 Annual Meeting. Coverage: https://www.ajmc.com/view/tirzepatide-plus-hormone-therapy-boosts-weight-loss-in-menopause-regina-castaneda-md [https://www.ajmc.com/view/tirzepatide-plus-hormone-therapy-boosts-weight-loss-in-menopause-regina-castaneda-md] * Lancet Obstetrics coverage of the same findings: https://www.sciencealert.com/unexpected-drug-combo-may-supercharge-weight-loss-in-older-women [https://www.sciencealert.com/unexpected-drug-combo-may-supercharge-weight-loss-in-older-women] * GLP-1 medications and testosterone recovery in men — presented at ENDO 2025, Endocrine Society Annual Meeting. Coverage: https://austinthyroid.com/how-glp-1-medications-may-boost-testosterone-naturally [https://austinthyroid.com/how-glp-1-medications-may-boost-testosterone-naturally] Go deeper: 📖 Better Off: The GLP-1 Protocol [https://rx.betteroff.com/books] 📖 Better Off: Weight Loss [https://rx.betteroff.com/books] 📋 Free Guide [https://rx.betteroff.com/guide] 🛒 Better Off Protein [https://rx.betteroff.com/protein] 📱 @betteroffwellness [https://instagram.com/betteroffwellness] on Instagram and TikTok I'm a nurse practitioner, I own a weight loss clinic, and this is education — not medical advice. Nothing here replaces a conversation with your own provider.
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